Synthesis and Evaluation of the Antiproliferative Activity of the Derivatives of 3,5-Diaryl-3,4-dihydro-2<i>H</i>-pyrrole-2-carboxylic Acids

Synthesis and Evaluation of the Antiproliferative Activity of the Derivatives of 3,5-Diaryl-3,4-dihydro-2<i>H</i>-pyrrole-2-carboxylic Acids

The metabolic cycle of L-proline plays a crucial role in cancer cell survival, proliferation, and metastasis. A key intermediate in the biosynthesis and degradation of proline is 3,4-dihydro-2<i>H</i>-pyrrole-2-carboxylic acid. A direct route for synthesizing substituted derivatives of t...

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Bibliographic Details
Main Authors: Vesela Mihaylova, Ivan Iliev, Anelia Vasileva, Elizabeth Mazzio, Bereket Mochona, Nelly Mateeva, Donka Tasheva
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Molecules
Subjects:
Michael addition
hydrolytic cyclization
3,4-dihydro-2<i>H</i>-pyrrole-2-carbonitriles
in vitro screening
antiproliferative activity
selectivity index
Online Access:https://www.mdpi.com/1420-3049/30/7/1602
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