Impact of probiotics on weight loss, glucose and lipid metabolism in overweight or obese women: A meta-analysis of randomized controlled trials
Our meta-analysis aimed to assess the effectiveness of probiotics in weight loss and glucose and lipid metabolism in overweight or obese women. PubMed, EMBASE, Cochrane Library, and Web of Science were used from inception until March 2024 to identify randomized controlled trials (RCT's) literat...
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Elsevier
2024-01-01
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| Series: | Current Research in Food Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665927124001369 |
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| author | Ning Cao Feiyan Zhao Lai-Yu Kwok Huan Wang Zhihong Sun |
| author_facet | Ning Cao Feiyan Zhao Lai-Yu Kwok Huan Wang Zhihong Sun |
| author_sort | Ning Cao |
| collection | DOAJ |
| description | Our meta-analysis aimed to assess the effectiveness of probiotics in weight loss and glucose and lipid metabolism in overweight or obese women. PubMed, EMBASE, Cochrane Library, and Web of Science were used from inception until March 2024 to identify randomized controlled trials (RCT's) literature. Finally, 11 RCTs were included. Following critical appraisal, a meta-analysis was conducted using the fixed effects model and the random effects model found that probiotic consumption significantly decreased waist circumference (WC) (SMD = −0.39 cm, 95% CI: −0.60, −0.18 cm, P < 0.00001, I2 = 33%), insulin (SMD = −0.45 mcU/ml; 95% CI: −0.72, −0.18 mcU/ml; P = 0.04, I2 = 40%) and low-density lipoprotein cholesterol (LDL-C) levels (SMD = −0.51 mmol/L; 95% CI: −0.92, −0.11 mmol/L; P = 0.02, I2 = 75%) in overweight or obese women. Moreover, subgroup analyses revealed that the effects of probiotic supplementation were significantly influenced by the intervention duration and diet and/or exercise intervention. This meta-analysis suggested that probiotic supplementation has a moderate and statistically significant effect on weight loss and glucose and lipid metabolism in overweight and obese women. |
| format | Article |
| id | doaj-art-3ba924f3452d44e7b6e3908df4584cea |
| institution | DOAJ |
| issn | 2665-9271 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Food Science |
| spelling | doaj-art-3ba924f3452d44e7b6e3908df4584cea2025-08-20T02:49:52ZengElsevierCurrent Research in Food Science2665-92712024-01-01910081010.1016/j.crfs.2024.100810Impact of probiotics on weight loss, glucose and lipid metabolism in overweight or obese women: A meta-analysis of randomized controlled trialsNing Cao0Feiyan Zhao1Lai-Yu Kwok2Huan Wang3Zhihong Sun4Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Hohhot, 010018, China; Key Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs, Hohhot, 010018, China; Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, 010018, China; School of Public Health, Inner Mongolia Medical University, Hohhot, 010110, ChinaInner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Hohhot, 010018, China; Key Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs, Hohhot, 010018, China; Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, 010018, ChinaInner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Hohhot, 010018, China; Key Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs, Hohhot, 010018, China; Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, 010018, ChinaInner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Hohhot, 010018, China; Key Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs, Hohhot, 010018, China; Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, 010018, China; People's Hospital of Inner Mongolia Autonomous Region, Hohhot, Inner Mongolia 010110, ChinaInner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Hohhot, 010018, China; Key Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs, Hohhot, 010018, China; Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, 010018, China; Corresponding author. Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Hohhot, 010018, China.Our meta-analysis aimed to assess the effectiveness of probiotics in weight loss and glucose and lipid metabolism in overweight or obese women. PubMed, EMBASE, Cochrane Library, and Web of Science were used from inception until March 2024 to identify randomized controlled trials (RCT's) literature. Finally, 11 RCTs were included. Following critical appraisal, a meta-analysis was conducted using the fixed effects model and the random effects model found that probiotic consumption significantly decreased waist circumference (WC) (SMD = −0.39 cm, 95% CI: −0.60, −0.18 cm, P < 0.00001, I2 = 33%), insulin (SMD = −0.45 mcU/ml; 95% CI: −0.72, −0.18 mcU/ml; P = 0.04, I2 = 40%) and low-density lipoprotein cholesterol (LDL-C) levels (SMD = −0.51 mmol/L; 95% CI: −0.92, −0.11 mmol/L; P = 0.02, I2 = 75%) in overweight or obese women. Moreover, subgroup analyses revealed that the effects of probiotic supplementation were significantly influenced by the intervention duration and diet and/or exercise intervention. This meta-analysis suggested that probiotic supplementation has a moderate and statistically significant effect on weight loss and glucose and lipid metabolism in overweight and obese women.http://www.sciencedirect.com/science/article/pii/S2665927124001369ProbioticsObesityGlucose metabolismLipid metabolismMeta-analysis |
| spellingShingle | Ning Cao Feiyan Zhao Lai-Yu Kwok Huan Wang Zhihong Sun Impact of probiotics on weight loss, glucose and lipid metabolism in overweight or obese women: A meta-analysis of randomized controlled trials Current Research in Food Science Probiotics Obesity Glucose metabolism Lipid metabolism Meta-analysis |
| title | Impact of probiotics on weight loss, glucose and lipid metabolism in overweight or obese women: A meta-analysis of randomized controlled trials |
| title_full | Impact of probiotics on weight loss, glucose and lipid metabolism in overweight or obese women: A meta-analysis of randomized controlled trials |
| title_fullStr | Impact of probiotics on weight loss, glucose and lipid metabolism in overweight or obese women: A meta-analysis of randomized controlled trials |
| title_full_unstemmed | Impact of probiotics on weight loss, glucose and lipid metabolism in overweight or obese women: A meta-analysis of randomized controlled trials |
| title_short | Impact of probiotics on weight loss, glucose and lipid metabolism in overweight or obese women: A meta-analysis of randomized controlled trials |
| title_sort | impact of probiotics on weight loss glucose and lipid metabolism in overweight or obese women a meta analysis of randomized controlled trials |
| topic | Probiotics Obesity Glucose metabolism Lipid metabolism Meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2665927124001369 |
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