Prospective Study on Tooth Loss and Risk of Esophageal Cancer Among Residents of A Natural Village in Wenfeng District, Anyang City, Henan Province
ObjectiveTo investigate the relationship between tooth loss and the occurrence of esophageal cancer in a natural village in Wenfeng District, Anyang City, Henan Province. MethodsA prospective cohort study was conducted to observe the occurrence of tooth loss and esophageal cancer among the asymptoma...
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Magazine House of Cancer Research on Prevention and Treatment
2025-07-01
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| Series: | Zhongliu Fangzhi Yanjiu |
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| Online Access: | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.1291 |
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| author | Jingjing WANG Ruihua XU Yanfang ZHANG Xueke ZHAO Qiang ZHANG Xin SONG Mengxia WEI Junfang GUO Xuena HAN Yaru FU Bei LI Junqing LIU Lingling LEI Min LIU Qide BAO Lidong WANG |
| author_facet | Jingjing WANG Ruihua XU Yanfang ZHANG Xueke ZHAO Qiang ZHANG Xin SONG Mengxia WEI Junfang GUO Xuena HAN Yaru FU Bei LI Junqing LIU Lingling LEI Min LIU Qide BAO Lidong WANG |
| author_sort | Jingjing WANG |
| collection | DOAJ |
| description | ObjectiveTo investigate the relationship between tooth loss and the occurrence of esophageal cancer in a natural village in Wenfeng District, Anyang City, Henan Province. MethodsA prospective cohort study was conducted to observe the occurrence of tooth loss and esophageal cancer among the asymptomatic residents of the natural village for 16 years from January 2008 to July 2024. Data were analyzed by chi-square test, binary logistic regression, and restricted cubic spline. ResultsAmong the total population of 711 cases, 136 cases were lost to follow-up and 575 cases were included in the final statistics, including 45 cases with esophageal cancer. Significant statistical difference was found between esophageal cancer patients with and without tooth loss (P<0.05). Logistic regression analysis showed that tooth loss was associated with the occurrence of esophageal cancer (OR=3.977, 95%CI: 1.543-10.255). After the adjustment for confounders, tooth loss remained significantly associated with the occurrence of esophageal cancer (OR=3.038, 95%CI: 1.035-8.914). A nonlinear dose-response relationship was observed between the number of teeth lost and the incidence of esophageal cancer. When the number of teeth lost was less than 12, the risk of esophageal cancer increased with the number of teeth lost. When more than 12 teeth were lost, the risk of esophageal cancer decreased as the number of teeth lost increased. ConclusionTooth loss is a risk factor for the occurrence of esophageal cancer in this natural village. When the number of teeth lost is less than 12, the risk of esophageal cancer increases with the number of teeth lost. |
| format | Article |
| id | doaj-art-3ba7b02fcd01426aa4e97ab7a0332581 |
| institution | DOAJ |
| issn | 1000-8578 |
| language | zho |
| publishDate | 2025-07-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
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| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj-art-3ba7b02fcd01426aa4e97ab7a03325812025-08-20T02:45:41ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782025-07-0152754855310.3971/j.issn.1000-8578.2025.24.129120241291Prospective Study on Tooth Loss and Risk of Esophageal Cancer Among Residents of A Natural Village in Wenfeng District, Anyang City, Henan ProvinceJingjing WANG0Ruihua XU1Yanfang ZHANG2Xueke ZHAO3Qiang ZHANG4Xin SONG5Mengxia WEI6Junfang GUO7Xuena HAN8Yaru FU9Bei LI10Junqing LIU11Lingling LEI12Min LIU13Qide BAO14Lidong WANG15Anyang District Hospital, Anyang 455000, ChinaState Key Laboratory of Esophageal Cancer Prevention and Treatment and Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaAnyang District Hospital, Anyang 455000, ChinaState Key Laboratory of Esophageal Cancer Prevention and Treatment and Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaAnyang District Hospital, Anyang 455000, ChinaState Key Laboratory of Esophageal Cancer Prevention and Treatment and Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaState Key Laboratory of Esophageal Cancer Prevention and Treatment and Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaAnyang District Hospital, Anyang 455000, ChinaState Key Laboratory of Esophageal Cancer Prevention and Treatment and Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaAnyang District Hospital, Anyang 455000, ChinaState Key Laboratory of Esophageal Cancer Prevention and Treatment and Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaAnyang District Hospital, Anyang 455000, ChinaState Key Laboratory of Esophageal Cancer Prevention and Treatment and Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaAnyang District Hospital, Anyang 455000, ChinaAnyang District Hospital, Anyang 455000, ChinaState Key Laboratory of Esophageal Cancer Prevention and Treatment and Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaObjectiveTo investigate the relationship between tooth loss and the occurrence of esophageal cancer in a natural village in Wenfeng District, Anyang City, Henan Province. MethodsA prospective cohort study was conducted to observe the occurrence of tooth loss and esophageal cancer among the asymptomatic residents of the natural village for 16 years from January 2008 to July 2024. Data were analyzed by chi-square test, binary logistic regression, and restricted cubic spline. ResultsAmong the total population of 711 cases, 136 cases were lost to follow-up and 575 cases were included in the final statistics, including 45 cases with esophageal cancer. Significant statistical difference was found between esophageal cancer patients with and without tooth loss (P<0.05). Logistic regression analysis showed that tooth loss was associated with the occurrence of esophageal cancer (OR=3.977, 95%CI: 1.543-10.255). After the adjustment for confounders, tooth loss remained significantly associated with the occurrence of esophageal cancer (OR=3.038, 95%CI: 1.035-8.914). A nonlinear dose-response relationship was observed between the number of teeth lost and the incidence of esophageal cancer. When the number of teeth lost was less than 12, the risk of esophageal cancer increased with the number of teeth lost. When more than 12 teeth were lost, the risk of esophageal cancer decreased as the number of teeth lost increased. ConclusionTooth loss is a risk factor for the occurrence of esophageal cancer in this natural village. When the number of teeth lost is less than 12, the risk of esophageal cancer increases with the number of teeth lost.http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.1291risk factortooth lossesophageal cancercohort study |
| spellingShingle | Jingjing WANG Ruihua XU Yanfang ZHANG Xueke ZHAO Qiang ZHANG Xin SONG Mengxia WEI Junfang GUO Xuena HAN Yaru FU Bei LI Junqing LIU Lingling LEI Min LIU Qide BAO Lidong WANG Prospective Study on Tooth Loss and Risk of Esophageal Cancer Among Residents of A Natural Village in Wenfeng District, Anyang City, Henan Province Zhongliu Fangzhi Yanjiu risk factor tooth loss esophageal cancer cohort study |
| title | Prospective Study on Tooth Loss and Risk of Esophageal Cancer Among Residents of A Natural Village in Wenfeng District, Anyang City, Henan Province |
| title_full | Prospective Study on Tooth Loss and Risk of Esophageal Cancer Among Residents of A Natural Village in Wenfeng District, Anyang City, Henan Province |
| title_fullStr | Prospective Study on Tooth Loss and Risk of Esophageal Cancer Among Residents of A Natural Village in Wenfeng District, Anyang City, Henan Province |
| title_full_unstemmed | Prospective Study on Tooth Loss and Risk of Esophageal Cancer Among Residents of A Natural Village in Wenfeng District, Anyang City, Henan Province |
| title_short | Prospective Study on Tooth Loss and Risk of Esophageal Cancer Among Residents of A Natural Village in Wenfeng District, Anyang City, Henan Province |
| title_sort | prospective study on tooth loss and risk of esophageal cancer among residents of a natural village in wenfeng district anyang city henan province |
| topic | risk factor tooth loss esophageal cancer cohort study |
| url | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.1291 |
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