RIPK1 kinase drove brain microvascular endothelial cells death and blood-brain barrier disruption in neonatal Escherichia coli meningitis

RIPK1 kinase drove brain microvascular endothelial cells death and blood-brain barrier disruption in neonatal Escherichia coli meningitis

Abstract Neonatal meningitis Escherichia coli (NMEC) breaching the blood-brain barrier (BBB) is a critical event in the development of E. coli meningitis. Brain microvascular endothelial cells (BMECs), the primary structural component of the BBB, play a central role in defending against pathogen inv...

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Bibliographic Details
Main Authors: Xuhang Wang, Yuhan Zhang, Xinru Chen, Kailai Fu, Jiaqi Cui, Jiaoling Wu, Yu Sun, Jianluan Ren, Feng Xue, Jianjun Dai, Fang Tang
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62760-4
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