Primary Gastric Lymphoma of MALT: Considerations of Pathogenesis, Diagnosis and Therapy
Primary gastric lymphoma of mucosa-associated lymphoid tissue (MALT) is a distinct entity with its own histological classification. Epidemiological, histomorphological, molecular biological and experimental data clearly underline that infection of the gastric mucosa by Helicobacter pylori plays an i...
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| Format: | Article |
| Language: | English |
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Wiley
2000-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2000/436854 |
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| _version_ | 1850217475072851968 |
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| author | Wolfgang Fischbach |
| author_facet | Wolfgang Fischbach |
| author_sort | Wolfgang Fischbach |
| collection | DOAJ |
| description | Primary gastric
lymphoma of mucosa-associated lymphoid tissue (MALT) is a distinct
entity with its own histological classification. Epidemiological,
histomorphological, molecular biological and experimental
data clearly underline that infection of the gastric mucosa by Helicobacter
pylori plays an important role in both the development
and progression of MALT lymphoma. Considering the histological
grade of malignancy and dissemination (stage) of the disease as
decisive prognostic factors, and therapeutic determinants, endoscopic
bioptical diagnosis and endoscopic ultrasound are of particular
importance. In cases of localized (stage 1), low grade
lymphoma, eradication of H pylori offers a promising and fascinating
therapeutic option. Surgical resection, radiotherapy or chemotherapy,
and their combination, have proven to be effective treatment
modalities. There is a need to clarify whether operative or
conservative therapeutic strategies should be favoured in the future. |
| format | Article |
| id | doaj-art-3b95ffa4b02b4cfcb7fb8e29631c272b |
| institution | OA Journals |
| issn | 0835-7900 |
| language | English |
| publishDate | 2000-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-3b95ffa4b02b4cfcb7fb8e29631c272b2025-08-20T02:08:02ZengWileyCanadian Journal of Gastroenterology0835-79002000-01-0114Suppl D44D50D10.1155/2000/436854Primary Gastric Lymphoma of MALT: Considerations of Pathogenesis, Diagnosis and TherapyWolfgang Fischbach0Medizinische Klinik II, Klinikum Aschaffenburg, Am Hasenkopf, Aschaffenburg, GermanyPrimary gastric lymphoma of mucosa-associated lymphoid tissue (MALT) is a distinct entity with its own histological classification. Epidemiological, histomorphological, molecular biological and experimental data clearly underline that infection of the gastric mucosa by Helicobacter pylori plays an important role in both the development and progression of MALT lymphoma. Considering the histological grade of malignancy and dissemination (stage) of the disease as decisive prognostic factors, and therapeutic determinants, endoscopic bioptical diagnosis and endoscopic ultrasound are of particular importance. In cases of localized (stage 1), low grade lymphoma, eradication of H pylori offers a promising and fascinating therapeutic option. Surgical resection, radiotherapy or chemotherapy, and their combination, have proven to be effective treatment modalities. There is a need to clarify whether operative or conservative therapeutic strategies should be favoured in the future.http://dx.doi.org/10.1155/2000/436854 |
| spellingShingle | Wolfgang Fischbach Primary Gastric Lymphoma of MALT: Considerations of Pathogenesis, Diagnosis and Therapy Canadian Journal of Gastroenterology |
| title | Primary Gastric Lymphoma of MALT: Considerations of Pathogenesis, Diagnosis and Therapy |
| title_full | Primary Gastric Lymphoma of MALT: Considerations of Pathogenesis, Diagnosis and Therapy |
| title_fullStr | Primary Gastric Lymphoma of MALT: Considerations of Pathogenesis, Diagnosis and Therapy |
| title_full_unstemmed | Primary Gastric Lymphoma of MALT: Considerations of Pathogenesis, Diagnosis and Therapy |
| title_short | Primary Gastric Lymphoma of MALT: Considerations of Pathogenesis, Diagnosis and Therapy |
| title_sort | primary gastric lymphoma of malt considerations of pathogenesis diagnosis and therapy |
| url | http://dx.doi.org/10.1155/2000/436854 |
| work_keys_str_mv | AT wolfgangfischbach primarygastriclymphomaofmaltconsiderationsofpathogenesisdiagnosisandtherapy |