Association between the dietary omega-6 to omega-3 fatty acid ratio and age-related macular degeneration in Korean adults
Abstract Background Long-chain polyunsaturated fatty acids of the omega-6 and omega-3 families affect processes implicated in vascular and neural retinal disease pathogenesis. This study aimed to investigate the association between the dietary omega-6 to omega-3 fatty acid ratio and age-related macu...
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| Format: | Article |
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BMC
2025-03-01
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| Series: | Nutrition Journal |
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| Online Access: | https://doi.org/10.1186/s12937-025-01090-z |
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| author | Won Jang Yuna Kim Hyesook Kim |
| author_facet | Won Jang Yuna Kim Hyesook Kim |
| author_sort | Won Jang |
| collection | DOAJ |
| description | Abstract Background Long-chain polyunsaturated fatty acids of the omega-6 and omega-3 families affect processes implicated in vascular and neural retinal disease pathogenesis. This study aimed to investigate the association between the dietary omega-6 to omega-3 fatty acid ratio and age-related macular degeneration (AMD). Methods We conducted a cross-sectional analysis using a nationwide representative sample of older adults (≥ 50 years), including 1,944 men and 2,592 women, from the Korea National Health and Nutrition Examination Survey (2017–2018). Omega-6 and omega-3 fatty acid intakes were collected through a 24-hour recall method and used to calculate the omega-6 to omega-3 fatty acid ratio. Associations between the ratio and AMD were determined using odds ratios (ORs) from multivariate logistic regressions. Results The prevalence of AMD was 19.8% and 17.7% in Korean men and women, respectively. In women, the multivariable-adjusted OR for incurring AMD was significantly higher in the 2nd (OR = 1.36; 95% CI = 1.02–1.81) and 3rd (OR = 1.36; 95% CI = 1.02–1.83) tertiles of the dietary omega-6 to omega-3 fatty acid ratio than in the 1st tertile (OR = 1, the reference OR) (P = 0.036 for this trend). However, this association was not observed in men. Conclusions These results suggest that high omega-6 to omega-3 fatty acid ratios may be associated with an increased prevalence of AMD among Korean women. |
| format | Article |
| id | doaj-art-3b92cd42d9a34ee9bb4da0a534165440 |
| institution | Kabale University |
| issn | 1475-2891 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition Journal |
| spelling | doaj-art-3b92cd42d9a34ee9bb4da0a5341654402025-08-20T03:52:23ZengBMCNutrition Journal1475-28912025-03-0124111010.1186/s12937-025-01090-zAssociation between the dietary omega-6 to omega-3 fatty acid ratio and age-related macular degeneration in Korean adultsWon Jang0Yuna Kim1Hyesook Kim2Department of Food and Nutrition, Wonkwang UniversityDepartment of Clinical Nutrition Science, The Graduate School of Clinical Health Sciences, Ewha Womans UniversityDepartment of Food and Nutrition, Wonkwang UniversityAbstract Background Long-chain polyunsaturated fatty acids of the omega-6 and omega-3 families affect processes implicated in vascular and neural retinal disease pathogenesis. This study aimed to investigate the association between the dietary omega-6 to omega-3 fatty acid ratio and age-related macular degeneration (AMD). Methods We conducted a cross-sectional analysis using a nationwide representative sample of older adults (≥ 50 years), including 1,944 men and 2,592 women, from the Korea National Health and Nutrition Examination Survey (2017–2018). Omega-6 and omega-3 fatty acid intakes were collected through a 24-hour recall method and used to calculate the omega-6 to omega-3 fatty acid ratio. Associations between the ratio and AMD were determined using odds ratios (ORs) from multivariate logistic regressions. Results The prevalence of AMD was 19.8% and 17.7% in Korean men and women, respectively. In women, the multivariable-adjusted OR for incurring AMD was significantly higher in the 2nd (OR = 1.36; 95% CI = 1.02–1.81) and 3rd (OR = 1.36; 95% CI = 1.02–1.83) tertiles of the dietary omega-6 to omega-3 fatty acid ratio than in the 1st tertile (OR = 1, the reference OR) (P = 0.036 for this trend). However, this association was not observed in men. Conclusions These results suggest that high omega-6 to omega-3 fatty acid ratios may be associated with an increased prevalence of AMD among Korean women.https://doi.org/10.1186/s12937-025-01090-zAge-related macular degenerationPolyunsaturated fatty acidsOmega-6Omega-3Korean national health and nutrition examination survey |
| spellingShingle | Won Jang Yuna Kim Hyesook Kim Association between the dietary omega-6 to omega-3 fatty acid ratio and age-related macular degeneration in Korean adults Nutrition Journal Age-related macular degeneration Polyunsaturated fatty acids Omega-6 Omega-3 Korean national health and nutrition examination survey |
| title | Association between the dietary omega-6 to omega-3 fatty acid ratio and age-related macular degeneration in Korean adults |
| title_full | Association between the dietary omega-6 to omega-3 fatty acid ratio and age-related macular degeneration in Korean adults |
| title_fullStr | Association between the dietary omega-6 to omega-3 fatty acid ratio and age-related macular degeneration in Korean adults |
| title_full_unstemmed | Association between the dietary omega-6 to omega-3 fatty acid ratio and age-related macular degeneration in Korean adults |
| title_short | Association between the dietary omega-6 to omega-3 fatty acid ratio and age-related macular degeneration in Korean adults |
| title_sort | association between the dietary omega 6 to omega 3 fatty acid ratio and age related macular degeneration in korean adults |
| topic | Age-related macular degeneration Polyunsaturated fatty acids Omega-6 Omega-3 Korean national health and nutrition examination survey |
| url | https://doi.org/10.1186/s12937-025-01090-z |
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