The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participants.

The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participants.

<h4>Background</h4>It is unclear whether C-reactive protein (CRP) is causally related to coronary heart disease (CHD). Genetic variants that are known to be associated with CRP levels can be used to provide causal inference of the effect of CRP on CHD. Our objective was to examine the as...

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Main Authors: Debbie A Lawlor, Roger M Harbord, Nic J Timpson, Gordon D O Lowe, Ann Rumley, Tom R Gaunt, Ian Baker, John W G Yarnell, Mika Kivimäki, Meena Kumari, Paul E Norman, Konrad Jamrozik, Graeme J Hankey, Osvaldo P Almeida, Leon Flicker, Nicole Warrington, Michael G Marmot, Yoav Ben-Shlomo, Lyle J Palmer, Ian N M Day, Shah Ebrahim, George Davey Smith
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-08-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0003011&type=printable
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