Association between Restless Legs Syndrome and Sleep Disturbance and 3-Year Mortality in Hemodialysis Patients
Introduction: Whether restless legs syndrome (RLS) and sleep disturbance (SD) in hemodialysis (HD) patients influence all-cause and cardiovascular mortality remains controversial. The aim of this study was to evaluate the association between RLS or SD and 3-year mortality in HD patients....
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2025-01-01
|
| Series: | Kidney Diseases |
| Online Access: | https://karger.com/article/doi/10.1159/000545008 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849727604822638592 |
|---|---|
| author | Lanbo Teng Huanan Li Yingying Han Tao Yuan Chuhan Xu Tao Tan Wenxiu Chang |
| author_facet | Lanbo Teng Huanan Li Yingying Han Tao Yuan Chuhan Xu Tao Tan Wenxiu Chang |
| author_sort | Lanbo Teng |
| collection | DOAJ |
| description |
Introduction: Whether restless legs syndrome (RLS) and sleep disturbance (SD) in hemodialysis (HD) patients influence all-cause and cardiovascular mortality remains controversial. The aim of this study was to evaluate the association between RLS or SD and 3-year mortality in HD patients. Methods: A total of 301 patients who underwent HD were examined in April 2021 and were followed up for 3 years. The median follow-up time was 36.0 [33.3, 36.0] months. Fifty-four patients fulfilled the diagnosis of RLS (17.9%), 126 patients complained of SD (41.9%). Demographic parameters, clinical features, laboratory indices, and two questionnaires to assess the diagnosis of RLS and sleep status were collected. All-cause mortality and cardiovascular mortality in this population were evaluated. Cox regression analyses and Kaplan-Meier curves were performed to determine the effect of RLS or SD on 3-year mortality. Results: The RLS group reported that 29 patients (53.8%) exhibited concurrent symptoms of SD. The presence of RLS or SD alone did not significantly elevate the risk of all-cause mortality (p = 0.053 and p = 0.193). However, the coexistence of RLS and SD was identified as an independent risk factor for all-cause mortality (p = 0.011). Furthermore, the various combinations associated with RLS or SD were found to be independently correlated with the risk of cardiovascular death (p < 0.05). Conclusion: The combination of RLS and SD in HD patients is associated with an increased risk of cardiovascular and all-cause mortality, underscoring the clinical significance of this association. |
| format | Article |
| id | doaj-art-3b8d00d8900c44fabc2ba504c0941378 |
| institution | DOAJ |
| issn | 2296-9357 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Kidney Diseases |
| spelling | doaj-art-3b8d00d8900c44fabc2ba504c09413782025-08-20T03:09:48ZengKarger PublishersKidney Diseases2296-93572025-01-0111116016910.1159/000545008Association between Restless Legs Syndrome and Sleep Disturbance and 3-Year Mortality in Hemodialysis PatientsLanbo TengHuanan LiYingying HanTao YuanChuhan XuTao TanWenxiu Chang Introduction: Whether restless legs syndrome (RLS) and sleep disturbance (SD) in hemodialysis (HD) patients influence all-cause and cardiovascular mortality remains controversial. The aim of this study was to evaluate the association between RLS or SD and 3-year mortality in HD patients. Methods: A total of 301 patients who underwent HD were examined in April 2021 and were followed up for 3 years. The median follow-up time was 36.0 [33.3, 36.0] months. Fifty-four patients fulfilled the diagnosis of RLS (17.9%), 126 patients complained of SD (41.9%). Demographic parameters, clinical features, laboratory indices, and two questionnaires to assess the diagnosis of RLS and sleep status were collected. All-cause mortality and cardiovascular mortality in this population were evaluated. Cox regression analyses and Kaplan-Meier curves were performed to determine the effect of RLS or SD on 3-year mortality. Results: The RLS group reported that 29 patients (53.8%) exhibited concurrent symptoms of SD. The presence of RLS or SD alone did not significantly elevate the risk of all-cause mortality (p = 0.053 and p = 0.193). However, the coexistence of RLS and SD was identified as an independent risk factor for all-cause mortality (p = 0.011). Furthermore, the various combinations associated with RLS or SD were found to be independently correlated with the risk of cardiovascular death (p < 0.05). Conclusion: The combination of RLS and SD in HD patients is associated with an increased risk of cardiovascular and all-cause mortality, underscoring the clinical significance of this association.https://karger.com/article/doi/10.1159/000545008 |
| spellingShingle | Lanbo Teng Huanan Li Yingying Han Tao Yuan Chuhan Xu Tao Tan Wenxiu Chang Association between Restless Legs Syndrome and Sleep Disturbance and 3-Year Mortality in Hemodialysis Patients Kidney Diseases |
| title | Association between Restless Legs Syndrome and Sleep Disturbance and 3-Year Mortality in Hemodialysis Patients |
| title_full | Association between Restless Legs Syndrome and Sleep Disturbance and 3-Year Mortality in Hemodialysis Patients |
| title_fullStr | Association between Restless Legs Syndrome and Sleep Disturbance and 3-Year Mortality in Hemodialysis Patients |
| title_full_unstemmed | Association between Restless Legs Syndrome and Sleep Disturbance and 3-Year Mortality in Hemodialysis Patients |
| title_short | Association between Restless Legs Syndrome and Sleep Disturbance and 3-Year Mortality in Hemodialysis Patients |
| title_sort | association between restless legs syndrome and sleep disturbance and 3 year mortality in hemodialysis patients |
| url | https://karger.com/article/doi/10.1159/000545008 |
| work_keys_str_mv | AT lanboteng associationbetweenrestlesslegssyndromeandsleepdisturbanceand3yearmortalityinhemodialysispatients AT huananli associationbetweenrestlesslegssyndromeandsleepdisturbanceand3yearmortalityinhemodialysispatients AT yingyinghan associationbetweenrestlesslegssyndromeandsleepdisturbanceand3yearmortalityinhemodialysispatients AT taoyuan associationbetweenrestlesslegssyndromeandsleepdisturbanceand3yearmortalityinhemodialysispatients AT chuhanxu associationbetweenrestlesslegssyndromeandsleepdisturbanceand3yearmortalityinhemodialysispatients AT taotan associationbetweenrestlesslegssyndromeandsleepdisturbanceand3yearmortalityinhemodialysispatients AT wenxiuchang associationbetweenrestlesslegssyndromeandsleepdisturbanceand3yearmortalityinhemodialysispatients |