Pesticide exposome reveals oxidative stress and immune response disruptions in occupationally exposed women with breast cancer

Pesticide exposome reveals oxidative stress and immune response disruptions in occupationally exposed women with breast cancer

Abstract Rural women are at a higher risk of developing breast cancer, but the molecular mechanisms involved remain poorly understood. This study investigates the impact of chronic pesticide exposure on systemic and tissue-level protein expressions in women diagnosed with breast cancer. Plasma and t...

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Main Authors: Juliana Maria Bitencourt de Morais Valentim, Luciana Pizzatti, Carolina Coradi, Isabella Cristina Cazagranda, Bruna Fadel, Beatriz Geovana Leite Vacario, Shaiane Carla Gaboardi, Matheus Iago Oliveira Coletto, Rodrigo Kern, Wander Rogério Pavanelli, Daniel Rech, Maria Luiza Ferreira dos Santos, Leonardo Foti, Allan Henrique Depieri Cataneo, Guilherme Ferreira Silveira, Juliano Bordignon, Fábio Rodrigues Ferreira Seiva, Carolina Panis
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Pesticides
Breast cancer
Oxidative stress
Immune response
Immune compromise
Online Access:https://doi.org/10.1038/s41598-025-12870-2
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