Adsorption and Desorption Characteristics of Simiao Yong’an Decoction on Macroporous Adsorption Resins
In this study, to identify an appropriate macroporous resin for the purification of the crude extract derived from Simiao Yong’an Decoction (SMYAD), five distinct resins were evaluated based on their adsorption and desorption performance. Through this comparative analysis, D101 macroporous adsorptio...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-03-01
|
| Series: | Separations |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2297-8739/12/4/84 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849714092545146880 |
|---|---|
| author | Wei Jiao Erhu Liu Yao Luo Yanxin Niu Yongxue Guo |
| author_facet | Wei Jiao Erhu Liu Yao Luo Yanxin Niu Yongxue Guo |
| author_sort | Wei Jiao |
| collection | DOAJ |
| description | In this study, to identify an appropriate macroporous resin for the purification of the crude extract derived from Simiao Yong’an Decoction (SMYAD), five distinct resins were evaluated based on their adsorption and desorption performance. Through this comparative analysis, D101 macroporous adsorption resin was determined to be the most suitable candidate. Investigations into the adsorption mechanism revealed that the process followed pseudo-second-order kinetics and was well described by the Langmuir isotherm model. Thermodynamic analysis further indicated the spontaneous and exothermic nature of the adsorption process. Through systematic optimization, the ideal purification parameters for SMYAD were established as follows: sample loading volume—6 bed volumes (BV), eluent concentration—90% ethanol (<i>v</i>/<i>v</i>), and eluent volume—3 BV, with both adsorption and desorption flow rates maintained at 3 BV/h. Finally, the purification effect was evaluated by fingerprint and similarity analysis. Under the optimal purification process, the content of the five index components was as follows: harpagide (4.26 mg/g), chlorogenic acid (38.37 mg/g), ferulic acid (4.78 mg/g), liquiritin (7.42 mg/g), and harpagoside (10.25 mg/g). The yield of the five components ranged from 70.74% to 86.26%. In conclusion, this approach demonstrates rapid processing capabilities and high efficiency, offering valuable methodological insights for the isolation and purification of complex traditional Chinese medicine formulations using macroporous adsorption resins. |
| format | Article |
| id | doaj-art-3b7bdcf044aa46ceaff11847ca1c8f56 |
| institution | DOAJ |
| issn | 2297-8739 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Separations |
| spelling | doaj-art-3b7bdcf044aa46ceaff11847ca1c8f562025-08-20T03:13:48ZengMDPI AGSeparations2297-87392025-03-011248410.3390/separations12040084Adsorption and Desorption Characteristics of Simiao Yong’an Decoction on Macroporous Adsorption ResinsWei Jiao0Erhu Liu1Yao Luo2Yanxin Niu3Yongxue Guo4School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Heping District, Shenyang 110016, ChinaShijiazhuang Woguang Technology Co., Ltd., No. 266, Gaoxin District, Shijiazhuang 050081, ChinaSchool of Pharmaceutical Engineering, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Heping District, Shenyang 110016, ChinaSchool of Pharmaceutical Engineering, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Heping District, Shenyang 110016, ChinaSchool of Pharmaceutical Engineering, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Heping District, Shenyang 110016, ChinaIn this study, to identify an appropriate macroporous resin for the purification of the crude extract derived from Simiao Yong’an Decoction (SMYAD), five distinct resins were evaluated based on their adsorption and desorption performance. Through this comparative analysis, D101 macroporous adsorption resin was determined to be the most suitable candidate. Investigations into the adsorption mechanism revealed that the process followed pseudo-second-order kinetics and was well described by the Langmuir isotherm model. Thermodynamic analysis further indicated the spontaneous and exothermic nature of the adsorption process. Through systematic optimization, the ideal purification parameters for SMYAD were established as follows: sample loading volume—6 bed volumes (BV), eluent concentration—90% ethanol (<i>v</i>/<i>v</i>), and eluent volume—3 BV, with both adsorption and desorption flow rates maintained at 3 BV/h. Finally, the purification effect was evaluated by fingerprint and similarity analysis. Under the optimal purification process, the content of the five index components was as follows: harpagide (4.26 mg/g), chlorogenic acid (38.37 mg/g), ferulic acid (4.78 mg/g), liquiritin (7.42 mg/g), and harpagoside (10.25 mg/g). The yield of the five components ranged from 70.74% to 86.26%. In conclusion, this approach demonstrates rapid processing capabilities and high efficiency, offering valuable methodological insights for the isolation and purification of complex traditional Chinese medicine formulations using macroporous adsorption resins.https://www.mdpi.com/2297-8739/12/4/84Simiao Yong’an decoctionChinese herbal medicinemacroporous resinsadsorption kineticsadsorption thermodynamics |
| spellingShingle | Wei Jiao Erhu Liu Yao Luo Yanxin Niu Yongxue Guo Adsorption and Desorption Characteristics of Simiao Yong’an Decoction on Macroporous Adsorption Resins Separations Simiao Yong’an decoction Chinese herbal medicine macroporous resins adsorption kinetics adsorption thermodynamics |
| title | Adsorption and Desorption Characteristics of Simiao Yong’an Decoction on Macroporous Adsorption Resins |
| title_full | Adsorption and Desorption Characteristics of Simiao Yong’an Decoction on Macroporous Adsorption Resins |
| title_fullStr | Adsorption and Desorption Characteristics of Simiao Yong’an Decoction on Macroporous Adsorption Resins |
| title_full_unstemmed | Adsorption and Desorption Characteristics of Simiao Yong’an Decoction on Macroporous Adsorption Resins |
| title_short | Adsorption and Desorption Characteristics of Simiao Yong’an Decoction on Macroporous Adsorption Resins |
| title_sort | adsorption and desorption characteristics of simiao yong an decoction on macroporous adsorption resins |
| topic | Simiao Yong’an decoction Chinese herbal medicine macroporous resins adsorption kinetics adsorption thermodynamics |
| url | https://www.mdpi.com/2297-8739/12/4/84 |
| work_keys_str_mv | AT weijiao adsorptionanddesorptioncharacteristicsofsimiaoyongandecoctiononmacroporousadsorptionresins AT erhuliu adsorptionanddesorptioncharacteristicsofsimiaoyongandecoctiononmacroporousadsorptionresins AT yaoluo adsorptionanddesorptioncharacteristicsofsimiaoyongandecoctiononmacroporousadsorptionresins AT yanxinniu adsorptionanddesorptioncharacteristicsofsimiaoyongandecoctiononmacroporousadsorptionresins AT yongxueguo adsorptionanddesorptioncharacteristicsofsimiaoyongandecoctiononmacroporousadsorptionresins |