Schisandrin B Attenuates Airway Inflammation by Regulating the NF-κB/Nrf2 Signaling Pathway in Mouse Models of Asthma
Background. Asthma is a complex inflammatory disorder that plagues a large number of people. Schisandrin B is an active ingredient of the traditional Chinese herbal medicine Schisandra with various proven physiological activities such as anti-inflammatory and antioxidant activities. In this study, w...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2021/8029963 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832561557984247808 |
|---|---|
| author | Yaqin Chen Yu Kong Qili Wang Jian Chen Hua Chen Huihui Xie Lan Li |
| author_facet | Yaqin Chen Yu Kong Qili Wang Jian Chen Hua Chen Huihui Xie Lan Li |
| author_sort | Yaqin Chen |
| collection | DOAJ |
| description | Background. Asthma is a complex inflammatory disorder that plagues a large number of people. Schisandrin B is an active ingredient of the traditional Chinese herbal medicine Schisandra with various proven physiological activities such as anti-inflammatory and antioxidant activities. In this study, we explored the anti-inflammatory and antioxidant effects and provided the mechanistic insights into the activity of schisandrin B in a mouse model of ovalbumin- (OVA-) induced allergic asthma. Methods. Male BALB/c mice were sensitized and challenged with OVA to induce asthma and treated with various doses (15 mg/kg, 30 mg/kg, and 60 mg/kg) of SCH to alleviate the features of allergic asthma, airway hyperresponsiveness, inflammatory response, OVA-specific immunoglobulin (Ig)E level, and pathological injury. Results. Schisandrin B significantly attenuated the airway hyperresponsiveness induced by OVA. Moreover, schisandrin B administration suppressed inflammatory responses, reduced the level of IgE, and attenuated pathological injury. Mechanistically, schisandrin B treatment promoted the activation of nuclear erythroid 2-related factor 2 (Nrf2), but suppressed the stimulation of the NF-κB pathway caused by OVA. Conclusion. Taken together, our study suggests that schisandrin B attenuates the features of asthmatic lungs by inhibiting the NF-κB pathway and activating the Nrf2 signaling pathway. |
| format | Article |
| id | doaj-art-3b785c24448248efb7322be9d4729957 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-3b785c24448248efb7322be9d47299572025-02-03T01:24:47ZengWileyJournal of Immunology Research2314-88612314-71562021-01-01202110.1155/2021/80299638029963Schisandrin B Attenuates Airway Inflammation by Regulating the NF-κB/Nrf2 Signaling Pathway in Mouse Models of AsthmaYaqin Chen0Yu Kong1Qili Wang2Jian Chen3Hua Chen4Huihui Xie5Lan Li6Department of Pediatrics, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, ChinaThe First Clinical Medical School, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, ChinaDepartment of Pediatrics, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, ChinaTricare Management Activity, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, ChinaTricare Management Activity, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, ChinaDepartment of Pediatrics, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, ChinaDepartment of Pediatrics, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, ChinaBackground. Asthma is a complex inflammatory disorder that plagues a large number of people. Schisandrin B is an active ingredient of the traditional Chinese herbal medicine Schisandra with various proven physiological activities such as anti-inflammatory and antioxidant activities. In this study, we explored the anti-inflammatory and antioxidant effects and provided the mechanistic insights into the activity of schisandrin B in a mouse model of ovalbumin- (OVA-) induced allergic asthma. Methods. Male BALB/c mice were sensitized and challenged with OVA to induce asthma and treated with various doses (15 mg/kg, 30 mg/kg, and 60 mg/kg) of SCH to alleviate the features of allergic asthma, airway hyperresponsiveness, inflammatory response, OVA-specific immunoglobulin (Ig)E level, and pathological injury. Results. Schisandrin B significantly attenuated the airway hyperresponsiveness induced by OVA. Moreover, schisandrin B administration suppressed inflammatory responses, reduced the level of IgE, and attenuated pathological injury. Mechanistically, schisandrin B treatment promoted the activation of nuclear erythroid 2-related factor 2 (Nrf2), but suppressed the stimulation of the NF-κB pathway caused by OVA. Conclusion. Taken together, our study suggests that schisandrin B attenuates the features of asthmatic lungs by inhibiting the NF-κB pathway and activating the Nrf2 signaling pathway.http://dx.doi.org/10.1155/2021/8029963 |
| spellingShingle | Yaqin Chen Yu Kong Qili Wang Jian Chen Hua Chen Huihui Xie Lan Li Schisandrin B Attenuates Airway Inflammation by Regulating the NF-κB/Nrf2 Signaling Pathway in Mouse Models of Asthma Journal of Immunology Research |
| title | Schisandrin B Attenuates Airway Inflammation by Regulating the NF-κB/Nrf2 Signaling Pathway in Mouse Models of Asthma |
| title_full | Schisandrin B Attenuates Airway Inflammation by Regulating the NF-κB/Nrf2 Signaling Pathway in Mouse Models of Asthma |
| title_fullStr | Schisandrin B Attenuates Airway Inflammation by Regulating the NF-κB/Nrf2 Signaling Pathway in Mouse Models of Asthma |
| title_full_unstemmed | Schisandrin B Attenuates Airway Inflammation by Regulating the NF-κB/Nrf2 Signaling Pathway in Mouse Models of Asthma |
| title_short | Schisandrin B Attenuates Airway Inflammation by Regulating the NF-κB/Nrf2 Signaling Pathway in Mouse Models of Asthma |
| title_sort | schisandrin b attenuates airway inflammation by regulating the nf κb nrf2 signaling pathway in mouse models of asthma |
| url | http://dx.doi.org/10.1155/2021/8029963 |
| work_keys_str_mv | AT yaqinchen schisandrinbattenuatesairwayinflammationbyregulatingthenfkbnrf2signalingpathwayinmousemodelsofasthma AT yukong schisandrinbattenuatesairwayinflammationbyregulatingthenfkbnrf2signalingpathwayinmousemodelsofasthma AT qiliwang schisandrinbattenuatesairwayinflammationbyregulatingthenfkbnrf2signalingpathwayinmousemodelsofasthma AT jianchen schisandrinbattenuatesairwayinflammationbyregulatingthenfkbnrf2signalingpathwayinmousemodelsofasthma AT huachen schisandrinbattenuatesairwayinflammationbyregulatingthenfkbnrf2signalingpathwayinmousemodelsofasthma AT huihuixie schisandrinbattenuatesairwayinflammationbyregulatingthenfkbnrf2signalingpathwayinmousemodelsofasthma AT lanli schisandrinbattenuatesairwayinflammationbyregulatingthenfkbnrf2signalingpathwayinmousemodelsofasthma |