Renal Thrombotic Microangiopathy Associated with the Use of Bortezomib in a Patient with Multiple Myeloma
Bortezomib is a first-generation proteasome inhibitor used in the treatment of multiple myeloma (MM). A few reports have linked bortezomib exposure with the development of thrombotic microangiopathy (TMA). We describe a case of biopsy-proven renal thrombotic microangiopathy associated with the use o...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2016/6020691 |
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| _version_ | 1832556058017529856 |
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| author | Jan Van Keer Michel Delforge Daan Dierickx Kathelijne Peerlinck Evelyne Lerut Ben Sprangers |
| author_facet | Jan Van Keer Michel Delforge Daan Dierickx Kathelijne Peerlinck Evelyne Lerut Ben Sprangers |
| author_sort | Jan Van Keer |
| collection | DOAJ |
| description | Bortezomib is a first-generation proteasome inhibitor used in the treatment of multiple myeloma (MM). A few reports have linked bortezomib exposure with the development of thrombotic microangiopathy (TMA). We describe a case of biopsy-proven renal thrombotic microangiopathy associated with the use of bortezomib in a 51-year-old man with IgG lambda MM. To our knowledge, this is the first biopsy-proven case. In addition, reexposure to bortezomib 18 months later was associated with recurrence of TMA. This supports a possible causal role of bortezomib. The exact mechanisms remain to be elucidated. |
| format | Article |
| id | doaj-art-3b766ca57bf944a6ad85e45c11c78434 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-3b766ca57bf944a6ad85e45c11c784342025-02-03T05:46:28ZengWileyCase Reports in Hematology2090-65602090-65792016-01-01201610.1155/2016/60206916020691Renal Thrombotic Microangiopathy Associated with the Use of Bortezomib in a Patient with Multiple MyelomaJan Van Keer0Michel Delforge1Daan Dierickx2Kathelijne Peerlinck3Evelyne Lerut4Ben Sprangers5Cardiology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, BelgiumHematology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, BelgiumHematology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, BelgiumVascular Medicine and Hemostasis, University Hospitals Leuven, Herestraat 49, 3000 Leuven, BelgiumPathology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, BelgiumNephrology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, BelgiumBortezomib is a first-generation proteasome inhibitor used in the treatment of multiple myeloma (MM). A few reports have linked bortezomib exposure with the development of thrombotic microangiopathy (TMA). We describe a case of biopsy-proven renal thrombotic microangiopathy associated with the use of bortezomib in a 51-year-old man with IgG lambda MM. To our knowledge, this is the first biopsy-proven case. In addition, reexposure to bortezomib 18 months later was associated with recurrence of TMA. This supports a possible causal role of bortezomib. The exact mechanisms remain to be elucidated.http://dx.doi.org/10.1155/2016/6020691 |
| spellingShingle | Jan Van Keer Michel Delforge Daan Dierickx Kathelijne Peerlinck Evelyne Lerut Ben Sprangers Renal Thrombotic Microangiopathy Associated with the Use of Bortezomib in a Patient with Multiple Myeloma Case Reports in Hematology |
| title | Renal Thrombotic Microangiopathy Associated with the Use of Bortezomib in a Patient with Multiple Myeloma |
| title_full | Renal Thrombotic Microangiopathy Associated with the Use of Bortezomib in a Patient with Multiple Myeloma |
| title_fullStr | Renal Thrombotic Microangiopathy Associated with the Use of Bortezomib in a Patient with Multiple Myeloma |
| title_full_unstemmed | Renal Thrombotic Microangiopathy Associated with the Use of Bortezomib in a Patient with Multiple Myeloma |
| title_short | Renal Thrombotic Microangiopathy Associated with the Use of Bortezomib in a Patient with Multiple Myeloma |
| title_sort | renal thrombotic microangiopathy associated with the use of bortezomib in a patient with multiple myeloma |
| url | http://dx.doi.org/10.1155/2016/6020691 |
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