Noninvasive Biomarkers of Colorectal Cancer: Role in Diagnosis and Personalised Treatment Perspectives
Colorectal cancer (CRC) is the third leading cause of cancer-related deaths worldwide. It has been estimated that more than one-third of patients are diagnosed when CRC has already spread to the lymph nodes. One out of five patients is diagnosed with metastatic CRC. The stage of diagnosis influences...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2018/2397863 |
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| author | Gianluca Pellino Gaetano Gallo Pierlorenzo Pallante Raffaella Capasso Alfonso De Stefano Isacco Maretto Umberto Malapelle Shengyang Qiu Stella Nikolaou Andrea Barina Giuseppe Clerico Alfonso Reginelli Antonio Giuliani Guido Sciaudone Christos Kontovounisios Luca Brunese Mario Trompetto Francesco Selvaggi |
| author_facet | Gianluca Pellino Gaetano Gallo Pierlorenzo Pallante Raffaella Capasso Alfonso De Stefano Isacco Maretto Umberto Malapelle Shengyang Qiu Stella Nikolaou Andrea Barina Giuseppe Clerico Alfonso Reginelli Antonio Giuliani Guido Sciaudone Christos Kontovounisios Luca Brunese Mario Trompetto Francesco Selvaggi |
| author_sort | Gianluca Pellino |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is the third leading cause of cancer-related deaths worldwide. It has been estimated that more than one-third of patients are diagnosed when CRC has already spread to the lymph nodes. One out of five patients is diagnosed with metastatic CRC. The stage of diagnosis influences treatment outcome and survival. Notwithstanding the recent advances in multidisciplinary management and treatment of CRC, patients are still reluctant to undergo screening tests because of the associated invasiveness and discomfort (e.g., colonoscopy with biopsies). Moreover, the serological markers currently used for diagnosis are not reliable and, even if they were useful to detect disease recurrence after treatment, they are not always detected in patients with CRC (e.g., CEA). Recently, translational research in CRC has produced a wide spectrum of potential biomarkers that could be useful for diagnosis, treatment, and follow-up of these patients. The aim of this review is to provide an overview of the newer noninvasive or minimally invasive biomarkers of CRC. Here, we discuss imaging and biomolecular diagnostics ranging from their potential usefulness to obtain early and less-invasive diagnosis to their potential implementation in the development of a bespoke treatment of CRC. |
| format | Article |
| id | doaj-art-3b763376e06347a3a33f6ffce0384ff2 |
| institution | OA Journals |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-3b763376e06347a3a33f6ffce0384ff22025-08-20T02:08:03ZengWileyGastroenterology Research and Practice1687-61211687-630X2018-01-01201810.1155/2018/23978632397863Noninvasive Biomarkers of Colorectal Cancer: Role in Diagnosis and Personalised Treatment PerspectivesGianluca Pellino0Gaetano Gallo1Pierlorenzo Pallante2Raffaella Capasso3Alfonso De Stefano4Isacco Maretto5Umberto Malapelle6Shengyang Qiu7Stella Nikolaou8Andrea Barina9Giuseppe Clerico10Alfonso Reginelli11Antonio Giuliani12Guido Sciaudone13Christos Kontovounisios14Luca Brunese15Mario Trompetto16Francesco Selvaggi17Unit of General Surgery, Department of Medical, Surgical, Neurological, Metabolic and Ageing Sciences, Università degli Studi della Campania “Luigi Vanvitelli”, Piazza Miraglia 2, 80138 Naples, ItalyDepartment of Medical and Surgical Sciences, OU of General Surgery, University of Catanzaro, Catanzaro, ItalyInstitute of Experimental Endocrinology and Oncology (IEOS), National Research Council (CNR), Via S. Pansini 5, Naples, ItalyDepartment of Medicine and Health Sciences, University of Molise, Via Francesco de Sanctis 1, 86100 Campobasso, ItalyDepartment of Abdominal Oncology, Division of Abdominal Medical Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, “Fondazione G. Pascale, ” IRCCS, Naples, Italy1st Surgical Clinic, Department of Surgical, Oncological, and Gastroenterological Sciences, University of Padua, Padua, ItalyDipartimento di Sanità Pubblica, Università degli Studi di Napoli Federico II, Naples, ItalyDepartment of Colorectal Surgery, Royal Marsden Hospital, London, UKDepartment of Colorectal Surgery, Royal Marsden Hospital, London, UK1st Surgical Clinic, Department of Surgical, Oncological, and Gastroenterological Sciences, University of Padua, Padua, ItalyDepartment of Colorectal Surgery, Clinic S. Rita, Vercelli, ItalyDepartment of Internal and Experimental Medicine, Magrassi-Lanzara, Institute of Radiology, Università degli Studi della Campania “Luigi Vanvitelli”, Piazza Miraglia 2, 80138 Naples, ItalyDepartment of Medicine and Health Sciences “V. Tiberio”, University of Molise, Campobasso, ItalyUnit of General Surgery, Department of Medical, Surgical, Neurological, Metabolic and Ageing Sciences, Università degli Studi della Campania “Luigi Vanvitelli”, Piazza Miraglia 2, 80138 Naples, ItalyDepartment of Colorectal Surgery, Royal Marsden Hospital, London, UKDepartment of Medicine and Health Sciences, University of Molise, Via Francesco de Sanctis 1, 86100 Campobasso, ItalyDepartment of Colorectal Surgery, Clinic S. Rita, Vercelli, ItalyUnit of General Surgery, Department of Medical, Surgical, Neurological, Metabolic and Ageing Sciences, Università degli Studi della Campania “Luigi Vanvitelli”, Piazza Miraglia 2, 80138 Naples, ItalyColorectal cancer (CRC) is the third leading cause of cancer-related deaths worldwide. It has been estimated that more than one-third of patients are diagnosed when CRC has already spread to the lymph nodes. One out of five patients is diagnosed with metastatic CRC. The stage of diagnosis influences treatment outcome and survival. Notwithstanding the recent advances in multidisciplinary management and treatment of CRC, patients are still reluctant to undergo screening tests because of the associated invasiveness and discomfort (e.g., colonoscopy with biopsies). Moreover, the serological markers currently used for diagnosis are not reliable and, even if they were useful to detect disease recurrence after treatment, they are not always detected in patients with CRC (e.g., CEA). Recently, translational research in CRC has produced a wide spectrum of potential biomarkers that could be useful for diagnosis, treatment, and follow-up of these patients. The aim of this review is to provide an overview of the newer noninvasive or minimally invasive biomarkers of CRC. Here, we discuss imaging and biomolecular diagnostics ranging from their potential usefulness to obtain early and less-invasive diagnosis to their potential implementation in the development of a bespoke treatment of CRC.http://dx.doi.org/10.1155/2018/2397863 |
| spellingShingle | Gianluca Pellino Gaetano Gallo Pierlorenzo Pallante Raffaella Capasso Alfonso De Stefano Isacco Maretto Umberto Malapelle Shengyang Qiu Stella Nikolaou Andrea Barina Giuseppe Clerico Alfonso Reginelli Antonio Giuliani Guido Sciaudone Christos Kontovounisios Luca Brunese Mario Trompetto Francesco Selvaggi Noninvasive Biomarkers of Colorectal Cancer: Role in Diagnosis and Personalised Treatment Perspectives Gastroenterology Research and Practice |
| title | Noninvasive Biomarkers of Colorectal Cancer: Role in Diagnosis and Personalised Treatment Perspectives |
| title_full | Noninvasive Biomarkers of Colorectal Cancer: Role in Diagnosis and Personalised Treatment Perspectives |
| title_fullStr | Noninvasive Biomarkers of Colorectal Cancer: Role in Diagnosis and Personalised Treatment Perspectives |
| title_full_unstemmed | Noninvasive Biomarkers of Colorectal Cancer: Role in Diagnosis and Personalised Treatment Perspectives |
| title_short | Noninvasive Biomarkers of Colorectal Cancer: Role in Diagnosis and Personalised Treatment Perspectives |
| title_sort | noninvasive biomarkers of colorectal cancer role in diagnosis and personalised treatment perspectives |
| url | http://dx.doi.org/10.1155/2018/2397863 |
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