RBAP48 facilitates the oral squamous cell carcinoma process in an androgen receptor-dependent and independent manners
Abstract Oral squamous cell carcinoma (OSCC) progresses from epithelial cell proliferation to malignancy. Given the higher proportion of male patients compared to female patients, the androgen signaling pathway is believed to play a significant role in promoting epithelial cell proliferation. Howeve...
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| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-05-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-025-08215-4 |
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| _version_ | 1850231415136845824 |
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| author | Xue Wang Guangqi Yan Hao Li Chunyu Wang Ye Kang Shengli Wang Wei Liu Lin Lin Renlong Zou Kai Zeng Manlin Wang Ruina Luan Baosheng Zhou Yu Bai Dongjun Yang Bolin Ning Ge Sun Yue Zhao |
| author_facet | Xue Wang Guangqi Yan Hao Li Chunyu Wang Ye Kang Shengli Wang Wei Liu Lin Lin Renlong Zou Kai Zeng Manlin Wang Ruina Luan Baosheng Zhou Yu Bai Dongjun Yang Bolin Ning Ge Sun Yue Zhao |
| author_sort | Xue Wang |
| collection | DOAJ |
| description | Abstract Oral squamous cell carcinoma (OSCC) progresses from epithelial cell proliferation to malignancy. Given the higher proportion of male patients compared to female patients, the androgen signaling pathway is believed to play a significant role in promoting epithelial cell proliferation. However, the underlying molecular mechanisms remain unclear. Here, we identified RBAP48 as a novel androgen receptor (AR) co-activator in OSCC cells. Our results show that RBAP48 was highly expressed in OSCC tumor tissues from patients with a poor prognosis. Further, RBAP48 knockdown decreased genome-wide oncogene transcription. RBAP48 and AR interacted to activate CCND1 and RAB31 transcription, and upregulated RELA and CCNE1 mRNA expression through an AR-independent pathway. Additionally, RBAP48 promoted OSCC cell proliferation and was involved in the cellular response to drugs and external compounds in vitro, ultimately driving cancer progression. Our results indicate that RBAP48 is a novel oncogene and a promising target for predicting and treating OSCC progression. |
| format | Article |
| id | doaj-art-3b73d22c7c6e4450a8b103be343a3edd |
| institution | OA Journals |
| issn | 2399-3642 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-3b73d22c7c6e4450a8b103be343a3edd2025-08-20T02:03:32ZengNature PortfolioCommunications Biology2399-36422025-05-018111510.1038/s42003-025-08215-4RBAP48 facilitates the oral squamous cell carcinoma process in an androgen receptor-dependent and independent mannersXue Wang0Guangqi Yan1Hao Li2Chunyu Wang3Ye Kang4Shengli Wang5Wei Liu6Lin Lin7Renlong Zou8Kai Zeng9Manlin Wang10Ruina Luan11Baosheng Zhou12Yu Bai13Dongjun Yang14Bolin Ning15Ge Sun16Yue Zhao17Department of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, and Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical UniversityDepartment of Oral and Maxillofacial Surgery, School of Stomatology, China Medical UniversityDepartment of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, and Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical UniversityDepartment of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, and Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical UniversityDepartment of pathology, Shengjing hospital of China Medical UniversityDepartment of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, and Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical UniversityDepartment of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, and Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical UniversityDepartment of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, and Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical UniversityDepartment of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, and Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical UniversityDepartment of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, and Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical UniversityDepartment of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, and Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical UniversityDepartment of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, and Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical UniversityDepartment of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, and Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical UniversityDepartment of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, and Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical UniversityDepartment of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, and Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical UniversityDepartment of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, and Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical UniversityDepartment of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, and Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical UniversityDepartment of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, and Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical UniversityAbstract Oral squamous cell carcinoma (OSCC) progresses from epithelial cell proliferation to malignancy. Given the higher proportion of male patients compared to female patients, the androgen signaling pathway is believed to play a significant role in promoting epithelial cell proliferation. However, the underlying molecular mechanisms remain unclear. Here, we identified RBAP48 as a novel androgen receptor (AR) co-activator in OSCC cells. Our results show that RBAP48 was highly expressed in OSCC tumor tissues from patients with a poor prognosis. Further, RBAP48 knockdown decreased genome-wide oncogene transcription. RBAP48 and AR interacted to activate CCND1 and RAB31 transcription, and upregulated RELA and CCNE1 mRNA expression through an AR-independent pathway. Additionally, RBAP48 promoted OSCC cell proliferation and was involved in the cellular response to drugs and external compounds in vitro, ultimately driving cancer progression. Our results indicate that RBAP48 is a novel oncogene and a promising target for predicting and treating OSCC progression.https://doi.org/10.1038/s42003-025-08215-4 |
| spellingShingle | Xue Wang Guangqi Yan Hao Li Chunyu Wang Ye Kang Shengli Wang Wei Liu Lin Lin Renlong Zou Kai Zeng Manlin Wang Ruina Luan Baosheng Zhou Yu Bai Dongjun Yang Bolin Ning Ge Sun Yue Zhao RBAP48 facilitates the oral squamous cell carcinoma process in an androgen receptor-dependent and independent manners Communications Biology |
| title | RBAP48 facilitates the oral squamous cell carcinoma process in an androgen receptor-dependent and independent manners |
| title_full | RBAP48 facilitates the oral squamous cell carcinoma process in an androgen receptor-dependent and independent manners |
| title_fullStr | RBAP48 facilitates the oral squamous cell carcinoma process in an androgen receptor-dependent and independent manners |
| title_full_unstemmed | RBAP48 facilitates the oral squamous cell carcinoma process in an androgen receptor-dependent and independent manners |
| title_short | RBAP48 facilitates the oral squamous cell carcinoma process in an androgen receptor-dependent and independent manners |
| title_sort | rbap48 facilitates the oral squamous cell carcinoma process in an androgen receptor dependent and independent manners |
| url | https://doi.org/10.1038/s42003-025-08215-4 |
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