EZH2 inhibitor SHR2554 enhances the anti-tumor efficacy of HDAC inhibitor Chidamide through STAT1 in T-cell lymphoma

Abstract T-cell lymphoma (TCL) is a rare subtype of non-Hodgkin lymphoma (NHL) that is associated with a poor prognosis. Although HDAC inhibitors have been approved for TCL treatment for several years, their expected therapeutic efficacy remains unmet in some patients. In this study, we discovered t...

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Bibliographic Details
Main Authors: Jiajin Wu, Dingyao Hu, Hui Yu, Dedao Wang, Yingying Ye, Jiaowu Cao, Tao Pan, Lan Mi, Yuqin Song, Meng Wu, Lingyan Ping, Jun Zhu
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07775-x
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