Harnessing the potential of Lactobacillus species for therapeutic delivery at the lumenal-mucosal interface
Lactobacillus species have been studied for over 30 years in their role as commensal organisms in the human gut. Recently there has been a surge of interest in their abilities to natively and recombinantly stimulate immune activities, and studies have identified strains and novel molecules that conv...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-04-01
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| Series: | Future Science OA |
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| Online Access: | https://www.future-science.com/doi/10.2144/fsoa-2020-0153 |
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| author | Joseph R Spangler Julie C Caruana Igor L Medintz Scott A Walper |
| author_facet | Joseph R Spangler Julie C Caruana Igor L Medintz Scott A Walper |
| author_sort | Joseph R Spangler |
| collection | DOAJ |
| description | Lactobacillus species have been studied for over 30 years in their role as commensal organisms in the human gut. Recently there has been a surge of interest in their abilities to natively and recombinantly stimulate immune activities, and studies have identified strains and novel molecules that convey particular advantages for applications as both immune adjuvants and immunomodulators. In this review, we discuss the recent advances in Lactobacillus-related activity at the gut/microbiota interface, the efforts to probe the boundaries of the direct and indirect therapeutic potential of these bacteria, and highlight the continued interest in harnessing the native capacity for the production of biogenic compounds shown to influence nervous system activity. Taken together, these aspects underscore Lactobacillus species as versatile therapeutic delivery vehicles capable of effector production at the lumenal-mucosal interface, and further establish a foundation of efficacy upon which future engineered strains can expand. |
| format | Article |
| id | doaj-art-3b6a336bf285496b8b885124badaef9f |
| institution | OA Journals |
| issn | 2056-5623 |
| language | English |
| publishDate | 2021-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Future Science OA |
| spelling | doaj-art-3b6a336bf285496b8b885124badaef9f2025-08-20T02:25:48ZengTaylor & Francis GroupFuture Science OA2056-56232021-04-017410.2144/fsoa-2020-0153Harnessing the potential of Lactobacillus species for therapeutic delivery at the lumenal-mucosal interfaceJoseph R Spangler0Julie C Caruana1Igor L Medintz2Scott A Walper31National Research Council Postdoctoral Fellow sited in US Naval Research Laboratory, Code 6900, Center for Bio/Molecular Science & Engineering, 4555 Overlook Ave SW, Washington DC, 20375, USA.2American Society for Engineering Education Postdoctoral Fellow sited in US Naval Research Laboratory, Code 6900, Center for Bio/Molecular Science & Engineering, 4555 Overlook Ave SW, Washington DC, 20375, USA.3US Naval Research Laboratory, Code 6900, Center for Bio/Molecular Science & Engineering, 4555 Overlook Ave SW, Washington DC, 20375, USA3US Naval Research Laboratory, Code 6900, Center for Bio/Molecular Science & Engineering, 4555 Overlook Ave SW, Washington DC, 20375, USALactobacillus species have been studied for over 30 years in their role as commensal organisms in the human gut. Recently there has been a surge of interest in their abilities to natively and recombinantly stimulate immune activities, and studies have identified strains and novel molecules that convey particular advantages for applications as both immune adjuvants and immunomodulators. In this review, we discuss the recent advances in Lactobacillus-related activity at the gut/microbiota interface, the efforts to probe the boundaries of the direct and indirect therapeutic potential of these bacteria, and highlight the continued interest in harnessing the native capacity for the production of biogenic compounds shown to influence nervous system activity. Taken together, these aspects underscore Lactobacillus species as versatile therapeutic delivery vehicles capable of effector production at the lumenal-mucosal interface, and further establish a foundation of efficacy upon which future engineered strains can expand.https://www.future-science.com/doi/10.2144/fsoa-2020-0153cytokine stimulationdelivery vehicleimmunomodulationLactobacillusmicrobiomeprobiotic |
| spellingShingle | Joseph R Spangler Julie C Caruana Igor L Medintz Scott A Walper Harnessing the potential of Lactobacillus species for therapeutic delivery at the lumenal-mucosal interface Future Science OA cytokine stimulation delivery vehicle immunomodulation Lactobacillus microbiome probiotic |
| title | Harnessing the potential of Lactobacillus species for therapeutic delivery at the lumenal-mucosal interface |
| title_full | Harnessing the potential of Lactobacillus species for therapeutic delivery at the lumenal-mucosal interface |
| title_fullStr | Harnessing the potential of Lactobacillus species for therapeutic delivery at the lumenal-mucosal interface |
| title_full_unstemmed | Harnessing the potential of Lactobacillus species for therapeutic delivery at the lumenal-mucosal interface |
| title_short | Harnessing the potential of Lactobacillus species for therapeutic delivery at the lumenal-mucosal interface |
| title_sort | harnessing the potential of lactobacillus species for therapeutic delivery at the lumenal mucosal interface |
| topic | cytokine stimulation delivery vehicle immunomodulation Lactobacillus microbiome probiotic |
| url | https://www.future-science.com/doi/10.2144/fsoa-2020-0153 |
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