Molecular basis for azetidine-2-carboxylic acid biosynthesis

Molecular basis for azetidine-2-carboxylic acid biosynthesis

Abstract Azetidine-2-carboxylic acid (AZE) is a long-known plant metabolite. Recently, AZE synthases have been identified in bacterial natural product pathways involving non-ribosomal peptide synthetases. AZE synthases catalyse the intramolecular 4-exo-tet cyclisation of S-adenosylmethionine (SAM),...

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Bibliographic Details
Main Authors: Tim J. Klaubert, Jonas Gellner, Charles Bernard, Juliana Effert, Carine Lombard, Ville R. I. Kaila, Helge B. Bode, Yanyan Li, Michael Groll
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56610-6
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