Advanced Silicon Modeling of Native Mitral Valve Physiology: A New Standard for Device and Procedure Testing
Mitral valve regurgitation is among the most prevalent valvular heart diseases and increases with age. Percutaneous therapy has emerged for the management of mitral regurgitation in high surgical risk patients. However, the long-term consequences of these interventions are still not fully understood...
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MDPI AG
2025-04-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/12/4/397 |
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| author | Katell Delanoë Erwan Salaun Régis Rieu Nancy Côté Philippe Pibarot Viktória Stanová |
| author_facet | Katell Delanoë Erwan Salaun Régis Rieu Nancy Côté Philippe Pibarot Viktória Stanová |
| author_sort | Katell Delanoë |
| collection | DOAJ |
| description | Mitral valve regurgitation is among the most prevalent valvular heart diseases and increases with age. Percutaneous therapy has emerged for the management of mitral regurgitation in high surgical risk patients. However, the long-term consequences of these interventions are still not fully understood due to their novelty and the difficulty of developing a strategy specific to the patient’s anatomy and/or pathology. To optimize these outcomes, an in vitro patient-specific approach could provide important insights for the most suitable strategy to use according to the patient profile. To ensure the reliability of this in vitro approach, the aim of this study was to reproduce the physiological behavior of the healthy native mitral valve for future applications. To do so, different silicon combinations reproducing the physiological anatomy of a healthy mitral valve were developed and tested under physiological hemodynamic conditions in a cardiac simulator. The hemodynamic and biomechanical behaviors of each mitral valve model were analyzed and compared to the physiological values provided in the literature. This study identified EcoFlex 00-50 and DragonSkin 10 (Smooth-On Inc., Easton, PA, USA) as the optimal silicon combination resulting in physiological strain values and hemodynamic parameters. These findings could be useful for future patient-specific applications, helping in the optimization of percutaneous mitral valve therapy. |
| format | Article |
| id | doaj-art-3b5d3156b97f4655ae0f6e07da1fe992 |
| institution | OA Journals |
| issn | 2306-5354 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj-art-3b5d3156b97f4655ae0f6e07da1fe9922025-08-20T02:17:14ZengMDPI AGBioengineering2306-53542025-04-0112439710.3390/bioengineering12040397Advanced Silicon Modeling of Native Mitral Valve Physiology: A New Standard for Device and Procedure TestingKatell Delanoë0Erwan Salaun1Régis Rieu2Nancy Côté3Philippe Pibarot4Viktória Stanová5Institut Universitaire de Cardiologie et de Pneumologie de Québec—Université Laval, Québec, QC G1V 4G5, CanadaInstitut Universitaire de Cardiologie et de Pneumologie de Québec—Université Laval, Québec, QC G1V 4G5, CanadaFaculté des Sciences Médicales et Paramédicales, Aix-Marseille Université, LBA UMR T24, 13015 Marseille, FranceInstitut Universitaire de Cardiologie et de Pneumologie de Québec—Université Laval, Québec, QC G1V 4G5, CanadaInstitut Universitaire de Cardiologie et de Pneumologie de Québec—Université Laval, Québec, QC G1V 4G5, CanadaInstitut Universitaire de Cardiologie et de Pneumologie de Québec—Université Laval, Québec, QC G1V 4G5, CanadaMitral valve regurgitation is among the most prevalent valvular heart diseases and increases with age. Percutaneous therapy has emerged for the management of mitral regurgitation in high surgical risk patients. However, the long-term consequences of these interventions are still not fully understood due to their novelty and the difficulty of developing a strategy specific to the patient’s anatomy and/or pathology. To optimize these outcomes, an in vitro patient-specific approach could provide important insights for the most suitable strategy to use according to the patient profile. To ensure the reliability of this in vitro approach, the aim of this study was to reproduce the physiological behavior of the healthy native mitral valve for future applications. To do so, different silicon combinations reproducing the physiological anatomy of a healthy mitral valve were developed and tested under physiological hemodynamic conditions in a cardiac simulator. The hemodynamic and biomechanical behaviors of each mitral valve model were analyzed and compared to the physiological values provided in the literature. This study identified EcoFlex 00-50 and DragonSkin 10 (Smooth-On Inc., Easton, PA, USA) as the optimal silicon combination resulting in physiological strain values and hemodynamic parameters. These findings could be useful for future patient-specific applications, helping in the optimization of percutaneous mitral valve therapy.https://www.mdpi.com/2306-5354/12/4/397mitral valvein vitrobiomechanicssiliconmodeling3D printing |
| spellingShingle | Katell Delanoë Erwan Salaun Régis Rieu Nancy Côté Philippe Pibarot Viktória Stanová Advanced Silicon Modeling of Native Mitral Valve Physiology: A New Standard for Device and Procedure Testing Bioengineering mitral valve in vitro biomechanics silicon modeling 3D printing |
| title | Advanced Silicon Modeling of Native Mitral Valve Physiology: A New Standard for Device and Procedure Testing |
| title_full | Advanced Silicon Modeling of Native Mitral Valve Physiology: A New Standard for Device and Procedure Testing |
| title_fullStr | Advanced Silicon Modeling of Native Mitral Valve Physiology: A New Standard for Device and Procedure Testing |
| title_full_unstemmed | Advanced Silicon Modeling of Native Mitral Valve Physiology: A New Standard for Device and Procedure Testing |
| title_short | Advanced Silicon Modeling of Native Mitral Valve Physiology: A New Standard for Device and Procedure Testing |
| title_sort | advanced silicon modeling of native mitral valve physiology a new standard for device and procedure testing |
| topic | mitral valve in vitro biomechanics silicon modeling 3D printing |
| url | https://www.mdpi.com/2306-5354/12/4/397 |
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