Transcription and chromatin organization of a housekeeping gene cluster containing an integrated beta-globin locus control region.

Transcription and chromatin organization of a housekeeping gene cluster containing an integrated beta-globin locus control region.

The activity of locus control regions (LCR) has been correlated with chromatin decondensation, spreading of active chromatin marks, locus repositioning away from its chromosome territory (CT), increased association with transcription factories, and long-range interactions via chromatin looping. To i...

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Bibliographic Details
Main Authors: Daan Noordermeer, Miguel R Branco, Erik Splinter, Petra Klous, Wilfred van Ijcken, Sigrid Swagemakers, Manousos Koutsourakis, Peter van der Spek, Ana Pombo, Wouter de Laat
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-03-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000016&type=printable
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