Soft matrix promotes immunosuppression in tumor-resident immune cells via COX-FGF2 signaling

Soft matrix promotes immunosuppression in tumor-resident immune cells via COX-FGF2 signaling

Abstract Mechanical forces of the tumor microenvironment change dynamically during key events of tumorigenesis such as invasion and metastasis. These changes in compressive forces often affect the breast cancer cell phenotype. However, it is lesser known how these dynamic mechanical forces in the tu...

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Main Authors: Aino Peura, Rita Turpin, Ruixian Liu, Maria Heilala, Maria Salmela, July Aung, Piia Mikkonen, Minna Mutka, Panu E. Kovanen, Laura Niinikoski, Tuomo Meretoja, Johanna Mattson, Päivi Heikkilä, Päivi Palanne, Tiina Kantanen, Mikko Kilpeläinen, Outi Ukkonen, Maija Hollmén, Topi A. Tervonen, Juha Klefström, Pauliina M. Munne
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60092-x
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