Effectiveness of a bedaquiline, linezolid, clofazimine ‘core’ for multidrug-resistant TB
INTRODUCTION: Costs for nutritional supplements and food were the main driver of costs incurred by TB-affected households in Lao People’s Democratic Republic. This study assessed the impact of nutritional counselling and support on costs incurred by TB-affected households. METHODS: We conducted long...
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International Union Against Tuberculosis and Lung Disease (The Union)
2025-05-01
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| author | C. Zeng M.A. Hernán L. Trevisi S. Sauer C.D. Mitnick C. Hewison M. Bastard P. Khan K.J. Seung M.L. Rich S. Law M. Kikvidze O. Kirakosyan A. Miankou P. Thit S. Mamsa A. Janmohamed N. Melikyan S. Ahmed D. Vargas A.B. Binegdie K. Temirova L. Oyewusi K. Philippe S.C. Vilbrun U. Khan H. Huerga M.F. Franke on behalf of the endTB Observational Study Team |
| author_facet | C. Zeng M.A. Hernán L. Trevisi S. Sauer C.D. Mitnick C. Hewison M. Bastard P. Khan K.J. Seung M.L. Rich S. Law M. Kikvidze O. Kirakosyan A. Miankou P. Thit S. Mamsa A. Janmohamed N. Melikyan S. Ahmed D. Vargas A.B. Binegdie K. Temirova L. Oyewusi K. Philippe S.C. Vilbrun U. Khan H. Huerga M.F. Franke on behalf of the endTB Observational Study Team |
| author_sort | C. Zeng |
| collection | DOAJ |
| description | INTRODUCTION: Costs for nutritional supplements and food were the main driver of costs incurred by TB-affected households in Lao People’s Democratic Republic. This study assessed the impact of nutritional counselling and support on costs incurred by TB-affected households. METHODS: We conducted longitudinal data collection of costs, income, and coping mechanisms of TB-affected households within an intervention study providing nutritional counselling and support for people diagnosed with TB and having a body mass index (BMI) <18.5 kg/m2. Data collection tools were adapted from the WHO’s generic national TB patient cost survey questionnaire to fit a longitudinal study design. Costs were considered catastrophic when they exceeded 20% of annual household income before TB. RESULTS: A total of 268 people treated for drug-susceptible TB were included in the analysis, and the prevalence of BMI <18.5 kg/m2 was 38%. The intervention group had significantly lower nutritional supplement costs and direct non-medical costs after TB diagnosis than the observation group. The intervention group had less progressive catastrophic costs (+23.3 percentage points) than the observation group (+30.9 percentage points). CONCLUSION: Nutritional counselling and support were significantly associated with a reduction in the proportion of TB-affected households facing catastrophic costs due to TB. |
| format | Article |
| id | doaj-art-3b59d5beac6f42d1a472cf5138e9b52a |
| institution | DOAJ |
| issn | 3005-7590 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | International Union Against Tuberculosis and Lung Disease (The Union) |
| record_format | Article |
| series | IJTLD Open |
| spelling | doaj-art-3b59d5beac6f42d1a472cf5138e9b52a2025-08-20T02:58:48ZengInternational Union Against Tuberculosis and Lung Disease (The Union)IJTLD Open3005-75902025-05-012526927510.5588/ijtldopen.24.05155Effectiveness of a bedaquiline, linezolid, clofazimine ‘core’ for multidrug-resistant TBC. Zeng0M.A. Hernán1L. Trevisi2S. Sauer3C.D. Mitnick4C. Hewison5M. Bastard6P. Khan7K.J. Seung8M.L. Rich9S. Law10M. Kikvidze11O. Kirakosyan12A. Miankou13P. Thit14S. Mamsa15A. Janmohamed16N. Melikyan17S. Ahmed18D. Vargas19A.B. Binegdie20K. Temirova21L. Oyewusi22K. Philippe23S.C. Vilbrun24U. Khan25H. Huerga26M.F. Franke27on behalf of the endTB Observational Study TeamDepartment of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA;CAUSALab, Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA;Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA;Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA;Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA;Medical Department, Médecins Sans Frontières (MSF), Paris, France;Field Epidemiology Department, Epicentre, Paris, France;Interactive Research and Development (IRD) Global, Singapore;Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA;Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA;Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA;MSF, Sokhumi, Georgia;MSF, Yerevan, Armenia;MSF, Minsk, Belarus;MSF, Yangon, Myanmar;Indus Hospital & Health Network (IHHN), Karachi, Pakistan;Interactive Research and Development, Karachi, Pakistan;Field Epidemiology Department, Epicentre, Paris, France;Interactive Research and Development, Karachi, Pakistan;PIH/Socios En Salud Sucursal Peru, Lima, Peru;Addis Ababa University College of Health Sciences, Department of Internal Medicine, Addis Ababa, Ethiopia;PIH, Almaty, Kazakhstan;PIH, Lesotho, Maseru, Lesotho;PIH, Port-au-Prince, Haiti;Haitian Group for the Study of Kaposi’s Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti;Interactive Research and Development (IRD) Global, Singapore;Field Epidemiology Department, Epicentre, Paris, France;Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA;INTRODUCTION: Costs for nutritional supplements and food were the main driver of costs incurred by TB-affected households in Lao People’s Democratic Republic. This study assessed the impact of nutritional counselling and support on costs incurred by TB-affected households. METHODS: We conducted longitudinal data collection of costs, income, and coping mechanisms of TB-affected households within an intervention study providing nutritional counselling and support for people diagnosed with TB and having a body mass index (BMI) <18.5 kg/m2. Data collection tools were adapted from the WHO’s generic national TB patient cost survey questionnaire to fit a longitudinal study design. Costs were considered catastrophic when they exceeded 20% of annual household income before TB. RESULTS: A total of 268 people treated for drug-susceptible TB were included in the analysis, and the prevalence of BMI <18.5 kg/m2 was 38%. The intervention group had significantly lower nutritional supplement costs and direct non-medical costs after TB diagnosis than the observation group. The intervention group had less progressive catastrophic costs (+23.3 percentage points) than the observation group (+30.9 percentage points). CONCLUSION: Nutritional counselling and support were significantly associated with a reduction in the proportion of TB-affected households facing catastrophic costs due to TB.https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2025/00000002/00000005/art00005fluoroquinolone resistancerifampicin resistancetarget trialinverse-probability weightingendtb observational studymdr-tbtuberculosis |
| spellingShingle | C. Zeng M.A. Hernán L. Trevisi S. Sauer C.D. Mitnick C. Hewison M. Bastard P. Khan K.J. Seung M.L. Rich S. Law M. Kikvidze O. Kirakosyan A. Miankou P. Thit S. Mamsa A. Janmohamed N. Melikyan S. Ahmed D. Vargas A.B. Binegdie K. Temirova L. Oyewusi K. Philippe S.C. Vilbrun U. Khan H. Huerga M.F. Franke on behalf of the endTB Observational Study Team Effectiveness of a bedaquiline, linezolid, clofazimine ‘core’ for multidrug-resistant TB IJTLD Open fluoroquinolone resistance rifampicin resistance target trial inverse-probability weighting endtb observational study mdr-tb tuberculosis |
| title | Effectiveness of a bedaquiline, linezolid, clofazimine ‘core’ for multidrug-resistant TB |
| title_full | Effectiveness of a bedaquiline, linezolid, clofazimine ‘core’ for multidrug-resistant TB |
| title_fullStr | Effectiveness of a bedaquiline, linezolid, clofazimine ‘core’ for multidrug-resistant TB |
| title_full_unstemmed | Effectiveness of a bedaquiline, linezolid, clofazimine ‘core’ for multidrug-resistant TB |
| title_short | Effectiveness of a bedaquiline, linezolid, clofazimine ‘core’ for multidrug-resistant TB |
| title_sort | effectiveness of a bedaquiline linezolid clofazimine core for multidrug resistant tb |
| topic | fluoroquinolone resistance rifampicin resistance target trial inverse-probability weighting endtb observational study mdr-tb tuberculosis |
| url | https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2025/00000002/00000005/art00005 |
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