ATP11B triggers the infiltration of T cells into GBM and intensifies anti-GBM immunity by upregulating and externalizing S1PR1

ATP11B triggers the infiltration of T cells into GBM and intensifies anti-GBM immunity by upregulating and externalizing S1PR1

Abstract Background Insufficient T-cell infiltration in tumours causes immune checkpoint inhibitor (ICI) resistance in glioblastoma (GBM) patients. The aim of this study was to demonstrate a preferable way to facilitate T-cell infiltration and improve the therapeutic effects of ICIs in GBM. Methods...

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Bibliographic Details
Main Authors: Hui Qiu, Ziqin Chen, Jie Chen, Huijuan Yu, Xin Wen, Chang Xu, Gongzhen Liu, Luyijie Chai, Longzhen Zhang, Yilong Guo, Xin Ding
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Translational Medicine
Subjects:
Glioblastoma
ATP11B
S1PR1
T-cell lymphopenia
Immune checkpoint inhibitor resistance
Online Access:https://doi.org/10.1186/s12967-025-06594-0
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