A Nanostring gene expression approach identifies aggressive clinical behavior related genes in dedifferentiated liposarcoma
Abstract Dedifferentiated liposarcoma (DDLPS) is one of the most common subtypes of soft tissue sarcoma with a highly variable clinical behavior. Despite advanced molecular approaches are exploring the genetic panorama of DDLPS progression, to date the driver genes of the aggressive clinical behavio...
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Nature Portfolio
2025-03-01
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| Online Access: | https://doi.org/10.1038/s41598-025-91791-6 |
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| author | Francesca Zalfa Paolo Manca Simone Carotti Silvia Vallese Daniela Righi Chiara Taffon Lorenzo Nibid Marta Sbaraglia Carla Rabitti Francesco Pantano Giuseppe Tonini Angelo Paolo Dei Tos Bruno Vincenzi Giuseppe Perrone |
| author_facet | Francesca Zalfa Paolo Manca Simone Carotti Silvia Vallese Daniela Righi Chiara Taffon Lorenzo Nibid Marta Sbaraglia Carla Rabitti Francesco Pantano Giuseppe Tonini Angelo Paolo Dei Tos Bruno Vincenzi Giuseppe Perrone |
| author_sort | Francesca Zalfa |
| collection | DOAJ |
| description | Abstract Dedifferentiated liposarcoma (DDLPS) is one of the most common subtypes of soft tissue sarcoma with a highly variable clinical behavior. Despite advanced molecular approaches are exploring the genetic panorama of DDLPS progression, to date the driver genes of the aggressive clinical behavior in DDLPS have not been identified yet. Here, we used a Nanostring nCounter approach to study the gene expression profile of 60 selected genes involved in DDLPS progression, in a cohort of DDLPS with aggressive clinical behavior, in comparison to a cohort of DDLPS with indolent clinical behavior. We identified five genes whose expression is significantly and consistently altered in aggressive compared to indolent DDLPS. Moreover, by a clinical outcome analyses we found MAP3K12 gene expression linked with both a higher risk of metastases and death. We envisage that the identified genes could represent the first genes of a genetic signature able to predict the clinical evolution of a DDLPS. |
| format | Article |
| id | doaj-art-3b581fc2fe9d481a9cdec178fb02f716 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-3b581fc2fe9d481a9cdec178fb02f7162025-08-20T02:51:23ZengNature PortfolioScientific Reports2045-23222025-03-0115111010.1038/s41598-025-91791-6A Nanostring gene expression approach identifies aggressive clinical behavior related genes in dedifferentiated liposarcomaFrancesca Zalfa0Paolo Manca1Simone Carotti2Silvia Vallese3Daniela Righi4Chiara Taffon5Lorenzo Nibid6Marta Sbaraglia7Carla Rabitti8Francesco Pantano9Giuseppe Tonini10Angelo Paolo Dei Tos11Bruno Vincenzi12Giuseppe Perrone13Operative Research Unit of Predictive Molecular Diagnostic, Fondazione Policlinico Universitario Campus Bio-MedicoMedical Oncology Department, Fondazione IRCCS Istituto Nazionale dei TumoriOperative Research Unit of Predictive Molecular Diagnostic, Fondazione Policlinico Universitario Campus Bio-MedicoPathology Unit, Bambino Gesù Children’s Hospital, IRCCSOperative Research Unit of Predictive Molecular Diagnostic, Fondazione Policlinico Universitario Campus Bio-MedicoOperative Research Unit of Anatomical Pathology, Fondazione Policlinico Universitario Campus Bio-MedicoOperative Research Unit of Anatomical Pathology, Fondazione Policlinico Universitario Campus Bio-MedicoDepartment of Medicine DIMED, University of PaduaOperative Research Unit of Anatomical Pathology, Fondazione Policlinico Universitario Campus Bio-MedicoOperative Research Unit of Oncology, Fondazione Policlinico Universitario Campus Bio-MedicoOperative Research Unit of Oncology, Fondazione Policlinico Universitario Campus Bio-MedicoDepartment of Medicine DIMED, University of PaduaOperative Research Unit of Oncology, Fondazione Policlinico Universitario Campus Bio-MedicoOperative Research Unit of Anatomical Pathology, Fondazione Policlinico Universitario Campus Bio-MedicoAbstract Dedifferentiated liposarcoma (DDLPS) is one of the most common subtypes of soft tissue sarcoma with a highly variable clinical behavior. Despite advanced molecular approaches are exploring the genetic panorama of DDLPS progression, to date the driver genes of the aggressive clinical behavior in DDLPS have not been identified yet. Here, we used a Nanostring nCounter approach to study the gene expression profile of 60 selected genes involved in DDLPS progression, in a cohort of DDLPS with aggressive clinical behavior, in comparison to a cohort of DDLPS with indolent clinical behavior. We identified five genes whose expression is significantly and consistently altered in aggressive compared to indolent DDLPS. Moreover, by a clinical outcome analyses we found MAP3K12 gene expression linked with both a higher risk of metastases and death. We envisage that the identified genes could represent the first genes of a genetic signature able to predict the clinical evolution of a DDLPS.https://doi.org/10.1038/s41598-025-91791-6DDLPSGene expressionNanoStringAggressive clinical behavior |
| spellingShingle | Francesca Zalfa Paolo Manca Simone Carotti Silvia Vallese Daniela Righi Chiara Taffon Lorenzo Nibid Marta Sbaraglia Carla Rabitti Francesco Pantano Giuseppe Tonini Angelo Paolo Dei Tos Bruno Vincenzi Giuseppe Perrone A Nanostring gene expression approach identifies aggressive clinical behavior related genes in dedifferentiated liposarcoma Scientific Reports DDLPS Gene expression NanoString Aggressive clinical behavior |
| title | A Nanostring gene expression approach identifies aggressive clinical behavior related genes in dedifferentiated liposarcoma |
| title_full | A Nanostring gene expression approach identifies aggressive clinical behavior related genes in dedifferentiated liposarcoma |
| title_fullStr | A Nanostring gene expression approach identifies aggressive clinical behavior related genes in dedifferentiated liposarcoma |
| title_full_unstemmed | A Nanostring gene expression approach identifies aggressive clinical behavior related genes in dedifferentiated liposarcoma |
| title_short | A Nanostring gene expression approach identifies aggressive clinical behavior related genes in dedifferentiated liposarcoma |
| title_sort | nanostring gene expression approach identifies aggressive clinical behavior related genes in dedifferentiated liposarcoma |
| topic | DDLPS Gene expression NanoString Aggressive clinical behavior |
| url | https://doi.org/10.1038/s41598-025-91791-6 |
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