Rechallenge therapy versus tyrosine kinase inhibitor (TKI) for advanced metastatic colorectal cancer: a retrospective study

Rechallenge therapy versus tyrosine kinase inhibitor (TKI) for advanced metastatic colorectal cancer: a retrospective study

Abstract Currently, the standard third-line treatment options for advanced metastatic colorectal cancer (mCRC) include regorafenib, fruquintinib, and trifluridine/tipiracil (TAS-102), but these drugs have limited clinical efficacy. This study aims to evaluate the efficacy and survival outcomes of ty...

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Bibliographic Details
Main Authors:	Chenming Liu, Jintao Chen, Yuxing Liu
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-02-01
Series:	Scientific Reports
Subjects:	Tyrosine kinase inhibitor Rechallenge therapy Metastatic colorectal cancer Overall survival Progression-free survival Propensity score matching
Online Access:	https://doi.org/10.1038/s41598-025-86575-x
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