Conventional and complementary alternative medicine therapies for renal anemia: a literature review
Renal anemia stems mainly from chronic inflammation with elevated hepcidin levels, iron deficiency, and reduced red blood cell lifespan. Inadequate erythropoietin (EPO) production, worsened kidney function, leads to symptoms such as low energy, fatigue, and impaired physical function, significantly...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1342873/full |
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| author | Ching-Ming Lu Ching-Ming Lu Yuan-Hsuan Hsu Yuan-Hsuan Hsu I-Hsin Lin Ko-Lin Kuo Jian-Fu Liao Hui-Fen Huang Hui-Fen Huang Ping-Hsun Lu Ping-Hsun Lu |
| author_facet | Ching-Ming Lu Ching-Ming Lu Yuan-Hsuan Hsu Yuan-Hsuan Hsu I-Hsin Lin Ko-Lin Kuo Jian-Fu Liao Hui-Fen Huang Hui-Fen Huang Ping-Hsun Lu Ping-Hsun Lu |
| author_sort | Ching-Ming Lu |
| collection | DOAJ |
| description | Renal anemia stems mainly from chronic inflammation with elevated hepcidin levels, iron deficiency, and reduced red blood cell lifespan. Inadequate erythropoietin (EPO) production, worsened kidney function, leads to symptoms such as low energy, fatigue, and impaired physical function, significantly affecting patients’ quality of life. We conducted a comprehensive search across electronic databases including PubMed, Embase, Cochrane Library, Chinese National Knowledge Infrastructure, Airiti library, and Wanfang, to compile recent clinical trials and pilot studies on conventional and complementary alternative medicine approaches for renal anemia. This discussion focuses on the hypoxia-inducible factor prolyl hydroxylase domain (HIF-PHD) axis theory, from lab research to clinical applications. It explores non-extracorporeal treatments for renal anemia, including pharmaceutical interventions, dietary strategies, and complementary and alternative medicine (CAM). The article details the effects of Roxadustat, Ferumoxytol, and Epodion.Clinical studies show that modulating the gut microbiome can reduce inflammation and improve renal anemia. Clinical trials suggest that CAM therapy can improve renal anemia through mechanisms such as enhanced iron metabolism, anti-inflammatory effects, reduced hepcidin levels, and increased EPO and HIF expressions. By synthesizing this information, the review aims to furnish valuable insights and treatment recommendations aimed at ameliorating renal anemia in individuals grappling with chronic kidney disease. |
| format | Article |
| id | doaj-art-3b4f4f82036a42059b79ed1ffe93be65 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-3b4f4f82036a42059b79ed1ffe93be652025-01-22T17:15:16ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-01-011510.3389/fendo.2024.13428731342873Conventional and complementary alternative medicine therapies for renal anemia: a literature reviewChing-Ming Lu0Ching-Ming Lu1Yuan-Hsuan Hsu2Yuan-Hsuan Hsu3I-Hsin Lin4Ko-Lin Kuo5Jian-Fu Liao6Hui-Fen Huang7Hui-Fen Huang8Ping-Hsun Lu9Ping-Hsun Lu10School of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien, TaiwanDepartment of Chinese Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, TaiwanSchool of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien, TaiwanDepartment of Chinese Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, TaiwanSchool of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien, TaiwanDivision of Nephrology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, TaiwanDivision of Nephrology, Tai An Hospital, Taipei, TaiwanSchool of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien, TaiwanDepartment of Chinese Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, TaiwanSchool of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien, TaiwanDepartment of Chinese Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, TaiwanRenal anemia stems mainly from chronic inflammation with elevated hepcidin levels, iron deficiency, and reduced red blood cell lifespan. Inadequate erythropoietin (EPO) production, worsened kidney function, leads to symptoms such as low energy, fatigue, and impaired physical function, significantly affecting patients’ quality of life. We conducted a comprehensive search across electronic databases including PubMed, Embase, Cochrane Library, Chinese National Knowledge Infrastructure, Airiti library, and Wanfang, to compile recent clinical trials and pilot studies on conventional and complementary alternative medicine approaches for renal anemia. This discussion focuses on the hypoxia-inducible factor prolyl hydroxylase domain (HIF-PHD) axis theory, from lab research to clinical applications. It explores non-extracorporeal treatments for renal anemia, including pharmaceutical interventions, dietary strategies, and complementary and alternative medicine (CAM). The article details the effects of Roxadustat, Ferumoxytol, and Epodion.Clinical studies show that modulating the gut microbiome can reduce inflammation and improve renal anemia. Clinical trials suggest that CAM therapy can improve renal anemia through mechanisms such as enhanced iron metabolism, anti-inflammatory effects, reduced hepcidin levels, and increased EPO and HIF expressions. By synthesizing this information, the review aims to furnish valuable insights and treatment recommendations aimed at ameliorating renal anemia in individuals grappling with chronic kidney disease.https://www.frontiersin.org/articles/10.3389/fendo.2024.1342873/fullchronic kidney diseasediet controldietary supplementcomplementary and alternative medicinerenal anemiaconventional medical therapy |
| spellingShingle | Ching-Ming Lu Ching-Ming Lu Yuan-Hsuan Hsu Yuan-Hsuan Hsu I-Hsin Lin Ko-Lin Kuo Jian-Fu Liao Hui-Fen Huang Hui-Fen Huang Ping-Hsun Lu Ping-Hsun Lu Conventional and complementary alternative medicine therapies for renal anemia: a literature review Frontiers in Endocrinology chronic kidney disease diet control dietary supplement complementary and alternative medicine renal anemia conventional medical therapy |
| title | Conventional and complementary alternative medicine therapies for renal anemia: a literature review |
| title_full | Conventional and complementary alternative medicine therapies for renal anemia: a literature review |
| title_fullStr | Conventional and complementary alternative medicine therapies for renal anemia: a literature review |
| title_full_unstemmed | Conventional and complementary alternative medicine therapies for renal anemia: a literature review |
| title_short | Conventional and complementary alternative medicine therapies for renal anemia: a literature review |
| title_sort | conventional and complementary alternative medicine therapies for renal anemia a literature review |
| topic | chronic kidney disease diet control dietary supplement complementary and alternative medicine renal anemia conventional medical therapy |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1342873/full |
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