Clinical significance of exosomal noncoding RNAs in hepatocellular carcinoma: a narrative review
Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide, with poor prognosis owing to its high frequency of recurrence and metastasis. Moreover, most patients are diagnosed at an advanced stage owing to a lack of early detection markers. Exosomes, which are characterized by t...
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| Format: | Article |
| Language: | English |
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Yeungnam University College of Medicine, Yeungnam University Institute Medical Science
2025-01-01
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| Series: | Journal of Yeungnam Medical Science |
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| Online Access: | http://www.e-jyms.org/upload/pdf/jyms-2023-01186.pdf |
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| _version_ | 1823859238783418368 |
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| author | Jae Sung Yoo Min Kyu Kang |
| author_facet | Jae Sung Yoo Min Kyu Kang |
| author_sort | Jae Sung Yoo |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide, with poor prognosis owing to its high frequency of recurrence and metastasis. Moreover, most patients are diagnosed at an advanced stage owing to a lack of early detection markers. Exosomes, which are characterized by their cargos of stable intracellular messengers, such as DNA, RNA, proteins, and lipids, play a crucial role in regulating cell differentiation and HCC development. Recently, exosomal noncoding RNAs (ncRNAs), including microRNAs, long ncRNAs, and circular RNAs, have become increasingly important diagnostic, prognostic, and predictive markers of HCC. Herein, we discuss the clinical implications of exosomal ncRNAs, specifically those within the HCC regulatory network. |
| format | Article |
| id | doaj-art-3b4e42e0d4964e3ba639e0fbec8fb8de |
| institution | Kabale University |
| issn | 2799-8010 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Yeungnam University College of Medicine, Yeungnam University Institute Medical Science |
| record_format | Article |
| series | Journal of Yeungnam Medical Science |
| spelling | doaj-art-3b4e42e0d4964e3ba639e0fbec8fb8de2025-02-11T06:26:37ZengYeungnam University College of Medicine, Yeungnam University Institute Medical ScienceJournal of Yeungnam Medical Science2799-80102025-01-014210.12701/jyms.2023.011862833Clinical significance of exosomal noncoding RNAs in hepatocellular carcinoma: a narrative reviewJae Sung Yoo0Min Kyu Kang1 Department of Gastroenterology and Hepatology, The Catholic University of Korea, Seoul St Mary’s Hospital, Seoul, Korea Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, KoreaHepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide, with poor prognosis owing to its high frequency of recurrence and metastasis. Moreover, most patients are diagnosed at an advanced stage owing to a lack of early detection markers. Exosomes, which are characterized by their cargos of stable intracellular messengers, such as DNA, RNA, proteins, and lipids, play a crucial role in regulating cell differentiation and HCC development. Recently, exosomal noncoding RNAs (ncRNAs), including microRNAs, long ncRNAs, and circular RNAs, have become increasingly important diagnostic, prognostic, and predictive markers of HCC. Herein, we discuss the clinical implications of exosomal ncRNAs, specifically those within the HCC regulatory network.http://www.e-jyms.org/upload/pdf/jyms-2023-01186.pdfcircular rnaexosomeshepatocellular carcinomalong noncoding rnamicrornas |
| spellingShingle | Jae Sung Yoo Min Kyu Kang Clinical significance of exosomal noncoding RNAs in hepatocellular carcinoma: a narrative review Journal of Yeungnam Medical Science circular rna exosomes hepatocellular carcinoma long noncoding rna micrornas |
| title | Clinical significance of exosomal noncoding RNAs in hepatocellular carcinoma: a narrative review |
| title_full | Clinical significance of exosomal noncoding RNAs in hepatocellular carcinoma: a narrative review |
| title_fullStr | Clinical significance of exosomal noncoding RNAs in hepatocellular carcinoma: a narrative review |
| title_full_unstemmed | Clinical significance of exosomal noncoding RNAs in hepatocellular carcinoma: a narrative review |
| title_short | Clinical significance of exosomal noncoding RNAs in hepatocellular carcinoma: a narrative review |
| title_sort | clinical significance of exosomal noncoding rnas in hepatocellular carcinoma a narrative review |
| topic | circular rna exosomes hepatocellular carcinoma long noncoding rna micrornas |
| url | http://www.e-jyms.org/upload/pdf/jyms-2023-01186.pdf |
| work_keys_str_mv | AT jaesungyoo clinicalsignificanceofexosomalnoncodingrnasinhepatocellularcarcinomaanarrativereview AT minkyukang clinicalsignificanceofexosomalnoncodingrnasinhepatocellularcarcinomaanarrativereview |