Modeling of Photochemical and Photothermal Effects in Soft Tissue Subjected to Laser Irradiation
The purpose of this study is to analyze the phenomena that occur in biological tissue during photodynamic therapy (PDT). Under the influence of the laser, triplet oxygen is transformed into singlet oxygen, which is cytotoxic to cancer tissue. The impact of the laser on the tissue may also be accomp...
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Institute of Fundamental Technological Research Polish Academy of Sciences
2023-12-01
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| Series: | Computer Assisted Methods in Engineering and Science |
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| Online Access: | https://cames.ippt.pan.pl/index.php/cames/article/view/1008 |
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| author | Marek Jasiński Maria Zadoń |
| author_facet | Marek Jasiński Maria Zadoń |
| author_sort | Marek Jasiński |
| collection | DOAJ |
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The purpose of this study is to analyze the phenomena that occur in biological tissue during photodynamic therapy (PDT). Under the influence of the laser, triplet oxygen is transformed into singlet oxygen, which is cytotoxic to cancer tissue. The impact of the laser on the tissue may also be accompanied by changes in the thermophysical parameters, e.g., perfusion, which can affect the supply of oxygen to the tissue and, consequently, the outcome of the therapy. The proposed model uses the optical diffusion equation, the Pennes bioheat transfer equation, and reactions equations for PDT. The connection between bioheat transfer and PDT models is taken into account through the respective relationships between perfusion rate, capillary blood velocity, and the maximum oxygen supply rate. Furthermore, a method is proposed to model abnormal vascular patterns in the tumor subdomain. The boundary element method and the finite difference method were used in the numerical implementation stage.
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| format | Article |
| id | doaj-art-3b48d8de909c4cdfbe889a8a4a8df37c |
| institution | Kabale University |
| issn | 2299-3649 2956-5839 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Institute of Fundamental Technological Research Polish Academy of Sciences |
| record_format | Article |
| series | Computer Assisted Methods in Engineering and Science |
| spelling | doaj-art-3b48d8de909c4cdfbe889a8a4a8df37c2025-08-20T03:28:55ZengInstitute of Fundamental Technological Research Polish Academy of SciencesComputer Assisted Methods in Engineering and Science2299-36492956-58392023-12-0131110.24423/cames.1008Modeling of Photochemical and Photothermal Effects in Soft Tissue Subjected to Laser IrradiationMarek Jasiński0Maria Zadoń1Silesian University of Technology, GliwiceSilesian University of Technology, Gliwice The purpose of this study is to analyze the phenomena that occur in biological tissue during photodynamic therapy (PDT). Under the influence of the laser, triplet oxygen is transformed into singlet oxygen, which is cytotoxic to cancer tissue. The impact of the laser on the tissue may also be accompanied by changes in the thermophysical parameters, e.g., perfusion, which can affect the supply of oxygen to the tissue and, consequently, the outcome of the therapy. The proposed model uses the optical diffusion equation, the Pennes bioheat transfer equation, and reactions equations for PDT. The connection between bioheat transfer and PDT models is taken into account through the respective relationships between perfusion rate, capillary blood velocity, and the maximum oxygen supply rate. Furthermore, a method is proposed to model abnormal vascular patterns in the tumor subdomain. The boundary element method and the finite difference method were used in the numerical implementation stage. https://cames.ippt.pan.pl/index.php/cames/article/view/1008bioheat transferoptical diffusion equationphotodynamic therapyboundary element methodfinite difference method |
| spellingShingle | Marek Jasiński Maria Zadoń Modeling of Photochemical and Photothermal Effects in Soft Tissue Subjected to Laser Irradiation Computer Assisted Methods in Engineering and Science bioheat transfer optical diffusion equation photodynamic therapy boundary element method finite difference method |
| title | Modeling of Photochemical and Photothermal Effects in Soft Tissue Subjected to Laser Irradiation |
| title_full | Modeling of Photochemical and Photothermal Effects in Soft Tissue Subjected to Laser Irradiation |
| title_fullStr | Modeling of Photochemical and Photothermal Effects in Soft Tissue Subjected to Laser Irradiation |
| title_full_unstemmed | Modeling of Photochemical and Photothermal Effects in Soft Tissue Subjected to Laser Irradiation |
| title_short | Modeling of Photochemical and Photothermal Effects in Soft Tissue Subjected to Laser Irradiation |
| title_sort | modeling of photochemical and photothermal effects in soft tissue subjected to laser irradiation |
| topic | bioheat transfer optical diffusion equation photodynamic therapy boundary element method finite difference method |
| url | https://cames.ippt.pan.pl/index.php/cames/article/view/1008 |
| work_keys_str_mv | AT marekjasinski modelingofphotochemicalandphotothermaleffectsinsofttissuesubjectedtolaserirradiation AT mariazadon modelingofphotochemicalandphotothermaleffectsinsofttissuesubjectedtolaserirradiation |