AI post-intervention operational and functional outcomes prediction in ischemic stroke patients using MRIs

Abstract Background Despite the potential clinical utility for acute ischemic stroke patients, predicting short-term operational outcomes like length of stay (LOS) and long-term functional outcomes such as the 90-day Modified Rankin Scale (mRS) remain a challenge, with limited current clinical guida...

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Main Authors: Emily Wittrup, John Reavey-Cantwell, Aditya S. Pandey, Dennis J. Rivet II, Kayvan Najarian
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Medical Imaging
Subjects:
Online Access:https://doi.org/10.1186/s12880-025-01864-1
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author Emily Wittrup
John Reavey-Cantwell
Aditya S. Pandey
Dennis J. Rivet II
Kayvan Najarian
author_facet Emily Wittrup
John Reavey-Cantwell
Aditya S. Pandey
Dennis J. Rivet II
Kayvan Najarian
author_sort Emily Wittrup
collection DOAJ
description Abstract Background Despite the potential clinical utility for acute ischemic stroke patients, predicting short-term operational outcomes like length of stay (LOS) and long-term functional outcomes such as the 90-day Modified Rankin Scale (mRS) remain a challenge, with limited current clinical guidance on expected patient trajectories. Machine learning approaches have increasingly aimed to bridge this gap, often utilizing admission-based clinical features; yet, the integration of imaging biomarkers remains underexplored, especially regarding whole 2.5D image fusion using advanced deep learning techniques. Methods This study introduces a novel method leveraging autoencoders to integrate 2.5D diffusion weighted imaging (DWI) with clinical features for refined outcome prediction. Results Results on a comprehensive dataset of AIS patients demonstrate that our autoencoder-based method has comparable performance to traditional convolutional neural networks image fusion methods and clinical data alone (LOS $$ > $$ 8 days: AUC 0.817, AUPRC 0.573, F1-Score 0.552; 90-day mRS $$>$$ 2: AUC 0.754, AUPRC 0.685, F1-Score 0.626). Conclusion This novel integration of imaging and clinical data for post-intervention stroke prognosis has numerous computational and operational advantages over traditional image fusion methods. While further validation of the presented models is necessary before adoption, this approach aims to enhance personalized patient management and operational decision-making in healthcare settings. Clinical trial number Not applicable.
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issn 1471-2342
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publishDate 2025-08-01
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spelling doaj-art-3b48b07e5f2b42acbc12d5775be028052025-08-20T03:43:31ZengBMCBMC Medical Imaging1471-23422025-08-0125111210.1186/s12880-025-01864-1AI post-intervention operational and functional outcomes prediction in ischemic stroke patients using MRIsEmily Wittrup0John Reavey-Cantwell1Aditya S. Pandey2Dennis J. Rivet II3Kayvan Najarian4Gilbert S. Omenn Computational Medicine and Bioinformatics, University of MichiganDepartment of Neurosurgery, Virginia Commonwealth UniversityDepartment of Neurosurgery, Michigan MedicineDepartment of Neurosurgery, Virginia Commonwealth UniversityGilbert S. Omenn Computational Medicine and Bioinformatics, University of MichiganAbstract Background Despite the potential clinical utility for acute ischemic stroke patients, predicting short-term operational outcomes like length of stay (LOS) and long-term functional outcomes such as the 90-day Modified Rankin Scale (mRS) remain a challenge, with limited current clinical guidance on expected patient trajectories. Machine learning approaches have increasingly aimed to bridge this gap, often utilizing admission-based clinical features; yet, the integration of imaging biomarkers remains underexplored, especially regarding whole 2.5D image fusion using advanced deep learning techniques. Methods This study introduces a novel method leveraging autoencoders to integrate 2.5D diffusion weighted imaging (DWI) with clinical features for refined outcome prediction. Results Results on a comprehensive dataset of AIS patients demonstrate that our autoencoder-based method has comparable performance to traditional convolutional neural networks image fusion methods and clinical data alone (LOS $$ > $$ 8 days: AUC 0.817, AUPRC 0.573, F1-Score 0.552; 90-day mRS $$>$$ 2: AUC 0.754, AUPRC 0.685, F1-Score 0.626). Conclusion This novel integration of imaging and clinical data for post-intervention stroke prognosis has numerous computational and operational advantages over traditional image fusion methods. While further validation of the presented models is necessary before adoption, this approach aims to enhance personalized patient management and operational decision-making in healthcare settings. Clinical trial number Not applicable.https://doi.org/10.1186/s12880-025-01864-1Acute ischemic strokeResnetAutoencoderDeep learningArtificial intelligenceMRI
spellingShingle Emily Wittrup
John Reavey-Cantwell
Aditya S. Pandey
Dennis J. Rivet II
Kayvan Najarian
AI post-intervention operational and functional outcomes prediction in ischemic stroke patients using MRIs
BMC Medical Imaging
Acute ischemic stroke
Resnet
Autoencoder
Deep learning
Artificial intelligence
MRI
title AI post-intervention operational and functional outcomes prediction in ischemic stroke patients using MRIs
title_full AI post-intervention operational and functional outcomes prediction in ischemic stroke patients using MRIs
title_fullStr AI post-intervention operational and functional outcomes prediction in ischemic stroke patients using MRIs
title_full_unstemmed AI post-intervention operational and functional outcomes prediction in ischemic stroke patients using MRIs
title_short AI post-intervention operational and functional outcomes prediction in ischemic stroke patients using MRIs
title_sort ai post intervention operational and functional outcomes prediction in ischemic stroke patients using mris
topic Acute ischemic stroke
Resnet
Autoencoder
Deep learning
Artificial intelligence
MRI
url https://doi.org/10.1186/s12880-025-01864-1
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