A sarcopenia prediction model based on the calf maximum muscle circumference measured by ultrasound
Abstract Background The correlation between calf circumference（CC）and sarcopenia has been demonstrated, but the correlation between calf maximum muscle circumference (CMMC) measured by ultrasound and sarcopenia has not been reported. We aims to construct a predictive model for sarcopenia based on CM...
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BMC
2025-02-01
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| Series: | BMC Geriatrics |
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| Online Access: | https://doi.org/10.1186/s12877-025-05733-y |
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| author | An Wei Yan Zou Zhen-Hua Tang Feng Guo Yan Zhou |
| author_facet | An Wei Yan Zou Zhen-Hua Tang Feng Guo Yan Zhou |
| author_sort | An Wei |
| collection | DOAJ |
| description | Abstract Background The correlation between calf circumference（CC）and sarcopenia has been demonstrated, but the correlation between calf maximum muscle circumference (CMMC) measured by ultrasound and sarcopenia has not been reported. We aims to construct a predictive model for sarcopenia based on CMMC in hospitalized older patients. Methods This was a retrospective controlled study of patients > 60 years of age hospitalized in the geriatric department of Hunan Provincial People’s Hospital. The patients were thoroughly evaluated by questionnaires, laboratory, and ultrasound examinations, including measuring muscle thickness and calf muscle maximum circumference using ultrasound. Patients were categorized into sarcopenia and non-sarcopenia groups according to the consensus for diagnosis of sarcopenia recommended by the Asian Working Group on Sarcopenia 2019 (AWGS2). Independent predictors of sarcopenia were identified by univariate and multivariate logistic regression analyses, and a predictive model was developed and simplified. The prediction performance of the models was assessed using sensitivity, specificity, and area under the curve (AUC) and compared with independent predictors. Results We found that patient age, albumin level (ALB), brachioradialis muscle thickness (BRMT), gastrocnemius lateral head muscle thickness (Glh MT), and calf maximum muscle circumference (CMMC) were independent predictors of sarcopenia in hospitalized older patients. The prediction model was established and simplified to Logistic P = -4.5 + 1.4 × age + 1.3 × ALB + 1.6 × BR MT + 3.7 × CMMC + 1.8 × Glh MT, and the best cut-off value of the model was 0.485. The sensitivity, specificity, and AUC of the model were 0.884 (0.807–0.962), 0.837 (0.762–0.911), and 0.927 (0.890–0.963), respectively. The kappa coefficient between this model and the diagnostic criteria recommended by AWGS2 was 0.709. Conclusion We constructed a sarcopenia prediction model with five variables: age, ALB level, BR MT, Glh MT, and CMMC. The model could quickly predict sarcopenia in older hospitalized patients. |
| format | Article |
| id | doaj-art-3b45d497b8c943e9887c6937c9448e92 |
| institution | Kabale University |
| issn | 1471-2318 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
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| series | BMC Geriatrics |
| spelling | doaj-art-3b45d497b8c943e9887c6937c9448e922025-02-09T12:53:33ZengBMCBMC Geriatrics1471-23182025-02-0125111210.1186/s12877-025-05733-yA sarcopenia prediction model based on the calf maximum muscle circumference measured by ultrasoundAn Wei0Yan Zou1Zhen-Hua Tang2Feng Guo3Yan Zhou4Department of Ultrasound, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal UniversityDepartment of International Medicine, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal UniversityDepartment of Ultrasound, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal UniversityDepartment of Ultrasound, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal UniversityDepartment of Geriatrics, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal UniversityAbstract Background The correlation between calf circumference（CC）and sarcopenia has been demonstrated, but the correlation between calf maximum muscle circumference (CMMC) measured by ultrasound and sarcopenia has not been reported. We aims to construct a predictive model for sarcopenia based on CMMC in hospitalized older patients. Methods This was a retrospective controlled study of patients > 60 years of age hospitalized in the geriatric department of Hunan Provincial People’s Hospital. The patients were thoroughly evaluated by questionnaires, laboratory, and ultrasound examinations, including measuring muscle thickness and calf muscle maximum circumference using ultrasound. Patients were categorized into sarcopenia and non-sarcopenia groups according to the consensus for diagnosis of sarcopenia recommended by the Asian Working Group on Sarcopenia 2019 (AWGS2). Independent predictors of sarcopenia were identified by univariate and multivariate logistic regression analyses, and a predictive model was developed and simplified. The prediction performance of the models was assessed using sensitivity, specificity, and area under the curve (AUC) and compared with independent predictors. Results We found that patient age, albumin level (ALB), brachioradialis muscle thickness (BRMT), gastrocnemius lateral head muscle thickness (Glh MT), and calf maximum muscle circumference (CMMC) were independent predictors of sarcopenia in hospitalized older patients. The prediction model was established and simplified to Logistic P = -4.5 + 1.4 × age + 1.3 × ALB + 1.6 × BR MT + 3.7 × CMMC + 1.8 × Glh MT, and the best cut-off value of the model was 0.485. The sensitivity, specificity, and AUC of the model were 0.884 (0.807–0.962), 0.837 (0.762–0.911), and 0.927 (0.890–0.963), respectively. The kappa coefficient between this model and the diagnostic criteria recommended by AWGS2 was 0.709. Conclusion We constructed a sarcopenia prediction model with five variables: age, ALB level, BR MT, Glh MT, and CMMC. The model could quickly predict sarcopenia in older hospitalized patients.https://doi.org/10.1186/s12877-025-05733-ySarcopeniaPrediction modelCalf muscle maximum circumferenceUltrasoundHospitalized older patients |
| spellingShingle | An Wei Yan Zou Zhen-Hua Tang Feng Guo Yan Zhou A sarcopenia prediction model based on the calf maximum muscle circumference measured by ultrasound BMC Geriatrics Sarcopenia Prediction model Calf muscle maximum circumference Ultrasound Hospitalized older patients |
| title | A sarcopenia prediction model based on the calf maximum muscle circumference measured by ultrasound |
| title_full | A sarcopenia prediction model based on the calf maximum muscle circumference measured by ultrasound |
| title_fullStr | A sarcopenia prediction model based on the calf maximum muscle circumference measured by ultrasound |
| title_full_unstemmed | A sarcopenia prediction model based on the calf maximum muscle circumference measured by ultrasound |
| title_short | A sarcopenia prediction model based on the calf maximum muscle circumference measured by ultrasound |
| title_sort | sarcopenia prediction model based on the calf maximum muscle circumference measured by ultrasound |
| topic | Sarcopenia Prediction model Calf muscle maximum circumference Ultrasound Hospitalized older patients |
| url | https://doi.org/10.1186/s12877-025-05733-y |
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