Design and evaluation of mRNA encoding recombinant neutralizing antibodies for botulinum neurotoxin type B intoxication prophylaxis

Design and evaluation of mRNA encoding recombinant neutralizing antibodies for botulinum neurotoxin type B intoxication prophylaxis

Among all natural and synthetic toxins, botulinum neurotoxins (BoNTs), produced by Clostridium botulinum in an anaerobic environment, are the most toxic polymer proteins. Currently, the most effective modalities for botulism prevention and treatment are vaccination and antitoxin use, respectively. H...

Full description

Saved in:

Bibliographic Details
Main Authors:	Gulisaina Qiaerxie, Yujia Jiang, Gege Li, Zhixin Yang, Feng Long, Yunzhou Yu, Jian Sheng Lu, Peng Du, Yong Cui
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2024-12-01
Series:	Human Vaccines & Immunotherapeutics
Subjects:	Botulinum neurotoxin mRNA prophylaxis heavy-chain antibody lipid nanoparticle
Online Access:	https://www.tandfonline.com/doi/10.1080/21645515.2024.2358570
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Overview of botulinum neurotoxin-producing clostridia in soils in France
by: Caroline Le Maréchal, et al.
Published: (2025-08-01)

Production of monoclonal antibodies against botulinum neurotoxin in Nicotiana benthamiana
by: Kornchanok Sangprasat, et al.
Published: (2024-12-01)

Novel Botulinum Neurotoxins: Exploring Underneath the Iceberg Tip
by: Domenico Azarnia Tehran, et al.
Published: (2018-05-01)

The Emerging Role of Botulinum Neurotoxin in Psoriasis Management: A Review of Mechanisms, Evidence, and Challenges
by: Ramadan S. Hussein
Published: (2025-03-01)

International Proficiency Test Targeting a Large Panel of Botulinum Neurotoxin Sero- and Subtypes in Different Matrices
by: Christine Rasetti-Escargueil, et al.
Published: (2024-11-01)

Development of a Recombinant Fusion Vaccine Candidate Against Lethal <i>Clostridium botulinum</i> Neurotoxin Types A and B
by: Eun-Sun Choi, et al.
Published: (2025-01-01)

An Effective Prophylactic and Therapeutic Protection Against Botulinum Type A Intoxication in Mice and Rabbits Using a Humanized Monoclonal Antibody
by: Chi Ho Yu, et al.
Published: (2025-03-01)

Incidence of Dysphagia and Comorbidities in Patients with Cervical Dystonia, Analyzed by Botulinum Neurotoxin Treatment Exposure
by: Richard L. Barbano, et al.
Published: (2025-03-01)

Applications, impacts and consequences of botulinum toxin usage in medicine
by: Weronika Kiełt, et al.
Published: (2024-10-01)

Do Diagnostic Nerve Blocks Affect the Starting Dose of Botulinum Neurotoxin Type A for Spasticity? A Case-Control Study
by: Mirko Filippetti, et al.
Published: (2024-09-01)

New approach to generating of human monoclonal antibodies specific to the proteolytic domain of botulinum neurotoxin A
by: Marina Vladimirovna Silkina, et al.
Published: (2024-07-01)

Histopathological changes of the buccal mucosa and skin after botulinum neurotoxin intramuscular injection in rats (immunohistochemical study)
by: Gihan S. Hassan, et al.
Published: (2025-02-01)

Do female and male patients with cervical dystonia respond differently to long-term botulinum neurotoxin therapy?
by: Harald Hefter, et al.
Published: (2025-06-01)

Botulinum Neurotoxin A-Induced Muscle Morphology Changes in Children with Cerebral Palsy: A One-Year Follow-Up Study
by: Charlotte Lambrechts, et al.
Published: (2025-06-01)

Combined treatment with antitoxin and 3,4-diaminopyridine improves survival outcomes after lethal botulinum neurotoxin challenge
by: Sean W. O’Brien, et al.
Published: (2025-07-01)

Expression of Recombinant Clostridial Neurotoxin by <i>C. tetani</i>
by: Brieana M. Gregg, et al.
Published: (2024-12-01)

Recombinant expression of receptor binding domains of all eight subtypes of botulinum neurotoxin type A for generation of antitoxins with broad reactivity [version 1; peer review: 1 approved, 2 approved with reservations]
by: Anh Thi Phuong Tran, et al.
Published: (2025-02-01)

Intramuscular Botulinum Neurotoxin Injections for Infantile Esotropia: A Durban Academic Hospital Review
by: Mohammed Khan, et al.
Published: (2025-02-01)

Economic Evaluation of the InTENSE Program of Therapy Alongside Botulinum Neurotoxin a for the Rehabilitation of Chronic Upper Limb Spasticity
by: Rachel Milte, et al.
Published: (2025-07-01)

The Use of Botulinum Toxin A in the Management of Trigeminal Neuralgia: a Systematic Literature Review
by: Anton Rubis, et al.
Published: (2020-06-01)

Single Tri-Epitopic Antibodies (TeAbs) to Botulinum Neurotoxin Serotypes B, E, and F Recapitulate the Full Potency of a Combination of Three Monoclonal Antibodies in Toxin Neutralization
by: Jianlong Lou, et al.
Published: (2025-06-01)

Botulism outbreak in cattle due to ingestion of accidental deteriorated feed
by: Milena Carolina Paz, et al.
Published: (2024-12-01)

Pathogenicity and virulence of Clostridium botulinum
by: Alexander M. Rawson, et al.
Published: (2023-12-01)

Hemimasticatory spasm. Own experience of using botulinum neuroprotein type A
by: A. N. Korenko, et al.
Published: (2022-04-01)

Stable Convergent Polyneuronal Innervation and Altered Synapse Elimination in <i>Orbicularis oculi</i> Muscles from Patients with Blepharospasm Responding Poorly to Recurrent Botulinum Type-A Neurotoxin Injections
by: Brigitte Girard, et al.
Published: (2024-11-01)

Simultaneous occurrence of type C botulism in poultry and dogs
by: Andressa S. Martins, et al.
Published: (2025-07-01)

Striatal Toe: Too Harmless to Treat?
by: Wolfgang H. Jost, et al.
Published: (2025-04-01)

Vast applications of botulinum neurotoxin in neurology - systematic review
by: Aleksandra Banach, et al.
Published: (2025-06-01)

Recombinant botulinum toxin as a new stage in the development of botulinum toxin therapy. Possibilities and perspectives of use in neurological practice
by: R. K. Shikhkerimov, et al.
Published: (2022-12-01)

Botulinum neurotoxin type-A for primary stabbing headache: an open study Toxina botulínica do tipo-A para o tratamento da cefaléia primária em punhaladas: um estudo aberto
by: Elcio Juliato Piovesan, et al.
Published: (2010-04-01)

Computational Immunogenetic Analysis of Botulinum Toxin A Immunogenicity and HLA Gene Haplotypes: New Insights
by: Eqram Rahman, et al.
Published: (2025-04-01)

Effects of Combined Vibration Ergometry and Botulinum Toxin on Gait Improvement in Asymmetric Lower Limb Spasticity: A Pilot Study
by: Harald Hefter, et al.
Published: (2025-01-01)

A nerve clamp electrode design for indirect stimulation of skeletal muscle
by: Corey J. Hilmas, et al.
Published: (2010-10-01)

Case Report: Combination of focal vibration therapy and botulinum toxin injections to treat equinus gait in a child with unilateral spastic cerebral palsy
by: Christophe Boulay, et al.
Published: (2025-02-01)

The Relationship Between Stiff Knee Gait Runner’s Dystonia and Musculoskeletal Knee Pathology: A Case Series
by: Jared A. Stowers, et al.
Published: (2025-03-01)

Efficacy and safety of valbenazine in the treatment of cervical dystonia: a pilot study
by: Salma Aziz, et al.
Published: (2025-05-01)

Botulinum neurotoxin type-A when utilized in animals with trigeminal sensitization induced a antinociceptive effect
by: Elcio J Piovesan, et al.
Published: (2016-06-01)

Botulinum toxin: yesterday, today, tomorrow
by: A. R. Artemenko, et al.
Published: (2015-02-01)

Efficacy of isolated periocular botulinum toxin A injections versus periocular and adjunctive lower facial injections in hemifacial spasm: a randomized, controlled, noninferiority, crossover trial
by: Akarawit Eiamsamarng, et al.
Published: (2025-12-01)

Serum and nasal lavage fluid eosinophil-derived neurotoxin levels and their determinants in adults
by: Saliha Selin Özuygur Ermis, MD, et al.
Published: (2025-08-01)