Evolution of spinal evoked compound action potential thresholds, visual motor thresholds, and impedances in a rodent spared nerve injury model
IntroductionThe mechanisms of spinal cord stimulation (SCS) on neuropathic pain are commonly studied using the spared nerve injury (SNI) model, with stimulation amplitudes typically programed relative to the visual motor threshold (vMT). Recent work explored the relationship between vMTs and spinal...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2025.1577059/full |
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| author | David L. Cedeño David L. Cedeño Ricardo Vallejo Ricardo Vallejo Ricardo Vallejo David C. Platt David C. Platt Joseph M. Williams Leonid M. Litvak David A. Dinsmoor Małgorzata Siorek |
| author_facet | David L. Cedeño David L. Cedeño Ricardo Vallejo Ricardo Vallejo Ricardo Vallejo David C. Platt David C. Platt Joseph M. Williams Leonid M. Litvak David A. Dinsmoor Małgorzata Siorek |
| author_sort | David L. Cedeño |
| collection | DOAJ |
| description | IntroductionThe mechanisms of spinal cord stimulation (SCS) on neuropathic pain are commonly studied using the spared nerve injury (SNI) model, with stimulation amplitudes typically programed relative to the visual motor threshold (vMT). Recent work explored the relationship between vMTs and spinal evoked compound action potential thresholds (ECAPTs)—a sensed measure of neural activation—in SNI rodents to better translate towards clinical dosing. However, changes across chronic healing beyond two days and pain states is unknown.MethodsThis study tracked ECAPs through a traditional SNI-SCS approach, where nine rats were implanted with an SCS lead to evaluate effects of acute healing (days 0 to 1), chronic healing (days 1 to 7), nerve injury (days 7 to 14), and continuous SCS (days 14 to 16) using differential target multiplexed programing (DTMP).ResultsECAPT:vMT ratios significantly increased on subsequent recordings from day 0 through day 14 (i.e., post-injury), but not between days 14 and 16 (after SCS), across anesthesia states, or SCS pulse widths. On average, ECAPT:vMT increased from 35 ± 2% (mean ± S.E.) on implantation day to 54 ± 1% on day 16.DiscussionFuture studies may use this approach to further elucidate the effects of chronic pain and SCS on the spinal ECAP. |
| format | Article |
| id | doaj-art-3b37b361c0db4da5a026d0996586de67 |
| institution | Kabale University |
| issn | 1662-453X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj-art-3b37b361c0db4da5a026d0996586de672025-08-20T03:28:09ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2025-06-011910.3389/fnins.2025.15770591577059Evolution of spinal evoked compound action potential thresholds, visual motor thresholds, and impedances in a rodent spared nerve injury modelDavid L. Cedeño0David L. Cedeño1Ricardo Vallejo2Ricardo Vallejo3Ricardo Vallejo4David C. Platt5David C. Platt6Joseph M. Williams7Leonid M. Litvak8David A. Dinsmoor9Małgorzata Siorek10SGX Medical LLC, Bloomington, IL, United StatesIllinois Wesleyan University, Bloomington, IL, United StatesSGX Medical LLC, Bloomington, IL, United StatesIllinois Wesleyan University, Bloomington, IL, United StatesMiVi, Barcelona, SpainSGX Medical LLC, Bloomington, IL, United StatesIllinois Wesleyan University, Bloomington, IL, United StatesIllinois Wesleyan University, Bloomington, IL, United StatesMedtronic plc, Minneapolis, MN, United StatesMedtronic plc, Minneapolis, MN, United StatesMedtronic plc, Minneapolis, MN, United StatesIntroductionThe mechanisms of spinal cord stimulation (SCS) on neuropathic pain are commonly studied using the spared nerve injury (SNI) model, with stimulation amplitudes typically programed relative to the visual motor threshold (vMT). Recent work explored the relationship between vMTs and spinal evoked compound action potential thresholds (ECAPTs)—a sensed measure of neural activation—in SNI rodents to better translate towards clinical dosing. However, changes across chronic healing beyond two days and pain states is unknown.MethodsThis study tracked ECAPs through a traditional SNI-SCS approach, where nine rats were implanted with an SCS lead to evaluate effects of acute healing (days 0 to 1), chronic healing (days 1 to 7), nerve injury (days 7 to 14), and continuous SCS (days 14 to 16) using differential target multiplexed programing (DTMP).ResultsECAPT:vMT ratios significantly increased on subsequent recordings from day 0 through day 14 (i.e., post-injury), but not between days 14 and 16 (after SCS), across anesthesia states, or SCS pulse widths. On average, ECAPT:vMT increased from 35 ± 2% (mean ± S.E.) on implantation day to 54 ± 1% on day 16.DiscussionFuture studies may use this approach to further elucidate the effects of chronic pain and SCS on the spinal ECAP.https://www.frontiersin.org/articles/10.3389/fnins.2025.1577059/fullevoked potentialsmotor threshold (MT)neuropathic pain (NP)rat modelECAPS |
| spellingShingle | David L. Cedeño David L. Cedeño Ricardo Vallejo Ricardo Vallejo Ricardo Vallejo David C. Platt David C. Platt Joseph M. Williams Leonid M. Litvak David A. Dinsmoor Małgorzata Siorek Evolution of spinal evoked compound action potential thresholds, visual motor thresholds, and impedances in a rodent spared nerve injury model Frontiers in Neuroscience evoked potentials motor threshold (MT) neuropathic pain (NP) rat model ECAPS |
| title | Evolution of spinal evoked compound action potential thresholds, visual motor thresholds, and impedances in a rodent spared nerve injury model |
| title_full | Evolution of spinal evoked compound action potential thresholds, visual motor thresholds, and impedances in a rodent spared nerve injury model |
| title_fullStr | Evolution of spinal evoked compound action potential thresholds, visual motor thresholds, and impedances in a rodent spared nerve injury model |
| title_full_unstemmed | Evolution of spinal evoked compound action potential thresholds, visual motor thresholds, and impedances in a rodent spared nerve injury model |
| title_short | Evolution of spinal evoked compound action potential thresholds, visual motor thresholds, and impedances in a rodent spared nerve injury model |
| title_sort | evolution of spinal evoked compound action potential thresholds visual motor thresholds and impedances in a rodent spared nerve injury model |
| topic | evoked potentials motor threshold (MT) neuropathic pain (NP) rat model ECAPS |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2025.1577059/full |
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