Decreased serum level of sphingosine‐1‐phosphate: a novel predictor of clinical severity in COVID‐19
Abstract The severity of coronavirus disease 2019 (COVID‐19) is a crucial problem in patient treatment and outcome. The aim of this study is to evaluate circulating level of sphingosine‐1‐phosphate (S1P) along with severity markers, in COVID‐19 patients. One hundred eleven COVID‐19 patients and fort...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer Nature
2020-12-01
|
| Series: | EMBO Molecular Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.15252/emmm.202013424 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849343577725861888 |
|---|---|
| author | Giovanni Marfia Stefania Navone Laura Guarnaccia Rolando Campanella Michele Mondoni Marco Locatelli Alessandra Barassi Laura Fontana Fabrizio Palumbo Emanuele Garzia Giuseppe Ciniglio Appiani Davide Chiumello Monica Miozzo Stefano Centanni Laura Riboni |
| author_facet | Giovanni Marfia Stefania Navone Laura Guarnaccia Rolando Campanella Michele Mondoni Marco Locatelli Alessandra Barassi Laura Fontana Fabrizio Palumbo Emanuele Garzia Giuseppe Ciniglio Appiani Davide Chiumello Monica Miozzo Stefano Centanni Laura Riboni |
| author_sort | Giovanni Marfia |
| collection | DOAJ |
| description | Abstract The severity of coronavirus disease 2019 (COVID‐19) is a crucial problem in patient treatment and outcome. The aim of this study is to evaluate circulating level of sphingosine‐1‐phosphate (S1P) along with severity markers, in COVID‐19 patients. One hundred eleven COVID‐19 patients and forty‐seven healthy subjects were included. The severity of COVID‐19 was found significantly associated with anemia, lymphocytopenia, and significant increase of neutrophil‐to‐lymphocyte ratio, ferritin, fibrinogen, aminotransferases, lactate dehydrogenase (LDH), C‐reactive protein (CRP), and D‐dimer. Serum S1P level was inversely associated with COVID‐19 severity, being significantly correlated with CRP, LDH, ferritin, and D‐dimer. The decrease in S1P was strongly associated with the number of erythrocytes, the major source of plasma S1P, and both apolipoprotein M and albumin, the major transporters of blood S1P. Not last, S1P was found to be a relevant predictor of admission to an intensive care unit, and patient’s outcome. Circulating S1P emerged as negative biomarker of severity/mortality of COVID‐19 patients. Restoring abnormal S1P levels to a normal range may have the potential to be a therapeutic target in patients with COVID‐19. |
| format | Article |
| id | doaj-art-3b2fac23170b4cebacddf12bd1e27b7d |
| institution | Kabale University |
| issn | 1757-4676 1757-4684 |
| language | English |
| publishDate | 2020-12-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-3b2fac23170b4cebacddf12bd1e27b7d2025-08-20T03:42:56ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842020-12-0113111110.15252/emmm.202013424Decreased serum level of sphingosine‐1‐phosphate: a novel predictor of clinical severity in COVID‐19Giovanni Marfia0Stefania Navone1Laura Guarnaccia2Rolando Campanella3Michele Mondoni4Marco Locatelli5Alessandra Barassi6Laura Fontana7Fabrizio Palumbo8Emanuele Garzia9Giuseppe Ciniglio Appiani10Davide Chiumello11Monica Miozzo12Stefano Centanni13Laura Riboni14Laboratory of Experimental Neurosurgery and Cell Therapy, Neurosurgery Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoLaboratory of Experimental Neurosurgery and Cell Therapy, Neurosurgery Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoLaboratory of Experimental Neurosurgery and Cell Therapy, Neurosurgery Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoLaboratory of Experimental Neurosurgery and Cell Therapy, Neurosurgery Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoRespiratory Unit, ASST Santi Paolo e Carlo, Department of Health Sciences, Università degli Studi di MilanoLaboratory of Experimental Neurosurgery and Cell Therapy, Neurosurgery Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoLaboratory of Clinical Biochemistry, ASST Santi Paolo e Carlo, Department of Health Sciences, Università degli Studi di MilanoDepartment of Medical‐Surgical Physiopathology and Transplantation, Università degli Studi di MilanoIstituto di Medicina Aerospaziale "A. Mosso", Aeronautica MilitareIstituto di Medicina Aerospaziale "A. Mosso", Aeronautica MilitareIstituto di Medicina Aerospaziale "A. Mosso", Aeronautica MilitareSC Anestesia e Rianimazione, ASST Santi Paolo e CarloDepartment of Medical‐Surgical Physiopathology and Transplantation, Università degli Studi di MilanoRespiratory Unit, ASST Santi Paolo e Carlo, Department of Health Sciences, Università degli Studi di MilanoDepartment of Medical Biotechnology and Translational Medicine, LITA‐Segrate, Università degli Studi di MilanoAbstract The severity of coronavirus disease 2019 (COVID‐19) is a crucial problem in patient treatment and outcome. The aim of this study is to evaluate circulating level of sphingosine‐1‐phosphate (S1P) along with severity markers, in COVID‐19 patients. One hundred eleven COVID‐19 patients and forty‐seven healthy subjects were included. The severity of COVID‐19 was found significantly associated with anemia, lymphocytopenia, and significant increase of neutrophil‐to‐lymphocyte ratio, ferritin, fibrinogen, aminotransferases, lactate dehydrogenase (LDH), C‐reactive protein (CRP), and D‐dimer. Serum S1P level was inversely associated with COVID‐19 severity, being significantly correlated with CRP, LDH, ferritin, and D‐dimer. The decrease in S1P was strongly associated with the number of erythrocytes, the major source of plasma S1P, and both apolipoprotein M and albumin, the major transporters of blood S1P. Not last, S1P was found to be a relevant predictor of admission to an intensive care unit, and patient’s outcome. Circulating S1P emerged as negative biomarker of severity/mortality of COVID‐19 patients. Restoring abnormal S1P levels to a normal range may have the potential to be a therapeutic target in patients with COVID‐19.https://doi.org/10.15252/emmm.202013424CoronavirusCOVID‐19intensive care unitprognostic biomarkersphingosine‐1‐phosphate |
| spellingShingle | Giovanni Marfia Stefania Navone Laura Guarnaccia Rolando Campanella Michele Mondoni Marco Locatelli Alessandra Barassi Laura Fontana Fabrizio Palumbo Emanuele Garzia Giuseppe Ciniglio Appiani Davide Chiumello Monica Miozzo Stefano Centanni Laura Riboni Decreased serum level of sphingosine‐1‐phosphate: a novel predictor of clinical severity in COVID‐19 EMBO Molecular Medicine Coronavirus COVID‐19 intensive care unit prognostic biomarker sphingosine‐1‐phosphate |
| title | Decreased serum level of sphingosine‐1‐phosphate: a novel predictor of clinical severity in COVID‐19 |
| title_full | Decreased serum level of sphingosine‐1‐phosphate: a novel predictor of clinical severity in COVID‐19 |
| title_fullStr | Decreased serum level of sphingosine‐1‐phosphate: a novel predictor of clinical severity in COVID‐19 |
| title_full_unstemmed | Decreased serum level of sphingosine‐1‐phosphate: a novel predictor of clinical severity in COVID‐19 |
| title_short | Decreased serum level of sphingosine‐1‐phosphate: a novel predictor of clinical severity in COVID‐19 |
| title_sort | decreased serum level of sphingosine 1 phosphate a novel predictor of clinical severity in covid 19 |
| topic | Coronavirus COVID‐19 intensive care unit prognostic biomarker sphingosine‐1‐phosphate |
| url | https://doi.org/10.15252/emmm.202013424 |
| work_keys_str_mv | AT giovannimarfia decreasedserumlevelofsphingosine1phosphateanovelpredictorofclinicalseverityincovid19 AT stefanianavone decreasedserumlevelofsphingosine1phosphateanovelpredictorofclinicalseverityincovid19 AT lauraguarnaccia decreasedserumlevelofsphingosine1phosphateanovelpredictorofclinicalseverityincovid19 AT rolandocampanella decreasedserumlevelofsphingosine1phosphateanovelpredictorofclinicalseverityincovid19 AT michelemondoni decreasedserumlevelofsphingosine1phosphateanovelpredictorofclinicalseverityincovid19 AT marcolocatelli decreasedserumlevelofsphingosine1phosphateanovelpredictorofclinicalseverityincovid19 AT alessandrabarassi decreasedserumlevelofsphingosine1phosphateanovelpredictorofclinicalseverityincovid19 AT laurafontana decreasedserumlevelofsphingosine1phosphateanovelpredictorofclinicalseverityincovid19 AT fabriziopalumbo decreasedserumlevelofsphingosine1phosphateanovelpredictorofclinicalseverityincovid19 AT emanuelegarzia decreasedserumlevelofsphingosine1phosphateanovelpredictorofclinicalseverityincovid19 AT giuseppeciniglioappiani decreasedserumlevelofsphingosine1phosphateanovelpredictorofclinicalseverityincovid19 AT davidechiumello decreasedserumlevelofsphingosine1phosphateanovelpredictorofclinicalseverityincovid19 AT monicamiozzo decreasedserumlevelofsphingosine1phosphateanovelpredictorofclinicalseverityincovid19 AT stefanocentanni decreasedserumlevelofsphingosine1phosphateanovelpredictorofclinicalseverityincovid19 AT laurariboni decreasedserumlevelofsphingosine1phosphateanovelpredictorofclinicalseverityincovid19 |