Association of hyperleptinemia with peripheral arterial disease in hypertensive patients
Objective: Hypertension is a risk factor for peripheral artery disease (PAD). Serum leptin plays an important role in promoting endothelial dysfunction. The aim of this study is to investigate whether the leptin level is associated with PAD in hypertensive patients. Materials and Methods: Ninety-eig...
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| Format: | Article |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Tzu Chi Medical Journal |
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| Online Access: | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2017;volume=29;issue=3;spage=148;epage=153;aulast=Huang |
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| _version_ | 1850193941501050880 |
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| author | I-Ching Huang Chao-Chien Chang Bang-Gee Hsu Chung-Jen Lee Ji-Hung Wang |
| author_facet | I-Ching Huang Chao-Chien Chang Bang-Gee Hsu Chung-Jen Lee Ji-Hung Wang |
| author_sort | I-Ching Huang |
| collection | DOAJ |
| description | Objective: Hypertension is a risk factor for peripheral artery disease (PAD). Serum leptin plays an important role in promoting endothelial dysfunction. The aim of this study is to investigate whether the leptin level is associated with PAD in hypertensive patients. Materials and Methods: Ninety-eight hypertensive patients were enrolled in this study. Ankle-brachial index (ABI) values were measured using an automated oscillometric device. Patients with an ABI value <0.9 were considered the low ABI group. C-reactive protein (CRP) was measured using standard enzymatic automated methods. Serum levels of human leptin were determined using a commercially available enzyme immunoassay. Results: Eighteen (18.4%) hypertensive patients were included in the low ABI group. Hypertensive patients in the low ABI group had higher serum creatinine (P < 0.001), CRP (P = 0.003), and leptin (P < 0.001) levels, higher prevalence of diabetes (P = 0.036), and current smoking (P = 0.034) than patients in the normal ABI group. Univariate linear regression analyses revealed that body weight (P = 0.014), waist circumference (P = 0.010), body mass index (P = 0.002), and logarithmically transformed CRP (log-CRP,P= 0.001) were positively correlated with serum log-leptin levels in hypertensive patients. Multivariate stepwise linear regression analysis showed that log-leptin (β = 0.439, adjusted R2 change = 0.224,P< 0.001) was also an associated factor of PAD in hypertensive patients. Conclusion: A higher log-leptin value is an independent predictor of PAD in hypertensive patients. |
| format | Article |
| id | doaj-art-3b2e37f6048d46a4879be6244a90f95c |
| institution | OA Journals |
| issn | 1016-3190 2223-8956 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Tzu Chi Medical Journal |
| spelling | doaj-art-3b2e37f6048d46a4879be6244a90f95c2025-08-20T02:14:07ZengWolters Kluwer Medknow PublicationsTzu Chi Medical Journal1016-31902223-89562017-01-0129314815310.4103/tcmj.tcmj_56_17Association of hyperleptinemia with peripheral arterial disease in hypertensive patientsI-Ching HuangChao-Chien ChangBang-Gee HsuChung-Jen LeeJi-Hung WangObjective: Hypertension is a risk factor for peripheral artery disease (PAD). Serum leptin plays an important role in promoting endothelial dysfunction. The aim of this study is to investigate whether the leptin level is associated with PAD in hypertensive patients. Materials and Methods: Ninety-eight hypertensive patients were enrolled in this study. Ankle-brachial index (ABI) values were measured using an automated oscillometric device. Patients with an ABI value <0.9 were considered the low ABI group. C-reactive protein (CRP) was measured using standard enzymatic automated methods. Serum levels of human leptin were determined using a commercially available enzyme immunoassay. Results: Eighteen (18.4%) hypertensive patients were included in the low ABI group. Hypertensive patients in the low ABI group had higher serum creatinine (P < 0.001), CRP (P = 0.003), and leptin (P < 0.001) levels, higher prevalence of diabetes (P = 0.036), and current smoking (P = 0.034) than patients in the normal ABI group. Univariate linear regression analyses revealed that body weight (P = 0.014), waist circumference (P = 0.010), body mass index (P = 0.002), and logarithmically transformed CRP (log-CRP,P= 0.001) were positively correlated with serum log-leptin levels in hypertensive patients. Multivariate stepwise linear regression analysis showed that log-leptin (β = 0.439, adjusted R2 change = 0.224,P< 0.001) was also an associated factor of PAD in hypertensive patients. Conclusion: A higher log-leptin value is an independent predictor of PAD in hypertensive patients.http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2017;volume=29;issue=3;spage=148;epage=153;aulast=HuangAnkle-brachial indexHypertensionLeptinPeripheral arterial disease |
| spellingShingle | I-Ching Huang Chao-Chien Chang Bang-Gee Hsu Chung-Jen Lee Ji-Hung Wang Association of hyperleptinemia with peripheral arterial disease in hypertensive patients Tzu Chi Medical Journal Ankle-brachial index Hypertension Leptin Peripheral arterial disease |
| title | Association of hyperleptinemia with peripheral arterial disease in hypertensive patients |
| title_full | Association of hyperleptinemia with peripheral arterial disease in hypertensive patients |
| title_fullStr | Association of hyperleptinemia with peripheral arterial disease in hypertensive patients |
| title_full_unstemmed | Association of hyperleptinemia with peripheral arterial disease in hypertensive patients |
| title_short | Association of hyperleptinemia with peripheral arterial disease in hypertensive patients |
| title_sort | association of hyperleptinemia with peripheral arterial disease in hypertensive patients |
| topic | Ankle-brachial index Hypertension Leptin Peripheral arterial disease |
| url | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2017;volume=29;issue=3;spage=148;epage=153;aulast=Huang |
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