The Effectiveness of the Combined Use of Meropenem and Avibactam Against Carbapenemase-Producing <i>Klebsiella pneumoniae</i> Strains in an <i>in vitro</i> Dynamic Model

The Effectiveness of the Combined Use of Meropenem and Avibactam Against Carbapenemase-Producing <i>Klebsiella pneumoniae</i> Strains in an <i>in vitro</i> Dynamic Model

Background. Combinations of carbapenems with new-generation carbapenemase inhibitors are successfully used to combat infections caused by carbapenemase-producing Klebsiella pneumoniae strains. However, K. pneumoniae resistance to such combinations is already described. Therefore, the search for new...

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Bibliographic Details
Main Authors: E. N. Strukova, M. V. Golikova, M. B. Kobrin, S. A. Dovzhenko, A. V. Golyshkin, N. R. Almyasheva, Yu. A. Portnoy
Format: Article
Language:Russian
Published: LLC "Publishing House OKI" 2025-04-01
Series:Антибиотики и Химиотерапия
Subjects:
meropenem, avibactam
k. pneumoniae
hollow fiber infection model, pharmacokinetics, pharmacodynamics
Online Access:https://www.antibiotics-chemotherapy.ru/jour/article/view/1203
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