Catalytic diazene synthesis from sterically hindered amines for deaminative functionalization
Abstract Primary amines are highly ubiquitous functional groups found in diverse natural products and building blocks. Despite their widespread application as nucleophiles, the potential for facile deaminative functionalization utilizing primary amines, particularly sterically hindered α-tertiary am...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-61662-9 |
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| author | Taro Tsuji Isora Fukumoto Takara Hario Mikihiro Hayashi Ayumi Osawa Takashi Ohshima Ryo Yazaki |
| author_facet | Taro Tsuji Isora Fukumoto Takara Hario Mikihiro Hayashi Ayumi Osawa Takashi Ohshima Ryo Yazaki |
| author_sort | Taro Tsuji |
| collection | DOAJ |
| description | Abstract Primary amines are highly ubiquitous functional groups found in diverse natural products and building blocks. Despite their widespread application as nucleophiles, the potential for facile deaminative functionalization utilizing primary amines, particularly sterically hindered α-tertiary amines, has remained less explored. Herein, we report catalytic direct synthesis of aliphatic diazenes from sterically hindered α-tertiary amines. The catalytic diazene synthetic method exhibits wide functional group tolerance, allowing for expeditious access to a wide array of hitherto-inaccessible, highly congested diazenes in a short time. Noteworthy is that the present catalytic method enables the synthesis of various hetero-diazenes using distinct α-tertiary amines in just one step for the first time. The catalytic process could also be readily incorporated into Fmoc solid-phase peptide synthesis, enabling the synthesis of elastin-derived diazene, which contains 12 amino acid residues. The catalytic diazene synthetic method enables efficient deaminative transformation of C–N bonds into C–halogen, C–H, C–O, C–S, C–Se, and C–C bonds through carbon-centered radical formation. |
| format | Article |
| id | doaj-art-3b23f075e7cc40a99f86d757a6060da5 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-3b23f075e7cc40a99f86d757a6060da52025-08-20T03:46:20ZengNature PortfolioNature Communications2041-17232025-07-0116111010.1038/s41467-025-61662-9Catalytic diazene synthesis from sterically hindered amines for deaminative functionalizationTaro Tsuji0Isora Fukumoto1Takara Hario2Mikihiro Hayashi3Ayumi Osawa4Takashi Ohshima5Ryo Yazaki6Graduate School of Pharmaceutical Sciences, Kyushu University, Maidashi, Higashi-kuGraduate School of Pharmaceutical Sciences, Kyushu University, Maidashi, Higashi-kuGraduate School of Pharmaceutical Sciences, Kyushu University, Maidashi, Higashi-kuDepartment of Life Science and Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho Showa-ku Nagoya-cityGraduate School of Pharmaceutical Sciences, Kyushu University, Maidashi, Higashi-kuGraduate School of Pharmaceutical Sciences, Kyushu University, Maidashi, Higashi-kuGraduate School of Pharmaceutical Sciences, Kyushu University, Maidashi, Higashi-kuAbstract Primary amines are highly ubiquitous functional groups found in diverse natural products and building blocks. Despite their widespread application as nucleophiles, the potential for facile deaminative functionalization utilizing primary amines, particularly sterically hindered α-tertiary amines, has remained less explored. Herein, we report catalytic direct synthesis of aliphatic diazenes from sterically hindered α-tertiary amines. The catalytic diazene synthetic method exhibits wide functional group tolerance, allowing for expeditious access to a wide array of hitherto-inaccessible, highly congested diazenes in a short time. Noteworthy is that the present catalytic method enables the synthesis of various hetero-diazenes using distinct α-tertiary amines in just one step for the first time. The catalytic process could also be readily incorporated into Fmoc solid-phase peptide synthesis, enabling the synthesis of elastin-derived diazene, which contains 12 amino acid residues. The catalytic diazene synthetic method enables efficient deaminative transformation of C–N bonds into C–halogen, C–H, C–O, C–S, C–Se, and C–C bonds through carbon-centered radical formation.https://doi.org/10.1038/s41467-025-61662-9 |
| spellingShingle | Taro Tsuji Isora Fukumoto Takara Hario Mikihiro Hayashi Ayumi Osawa Takashi Ohshima Ryo Yazaki Catalytic diazene synthesis from sterically hindered amines for deaminative functionalization Nature Communications |
| title | Catalytic diazene synthesis from sterically hindered amines for deaminative functionalization |
| title_full | Catalytic diazene synthesis from sterically hindered amines for deaminative functionalization |
| title_fullStr | Catalytic diazene synthesis from sterically hindered amines for deaminative functionalization |
| title_full_unstemmed | Catalytic diazene synthesis from sterically hindered amines for deaminative functionalization |
| title_short | Catalytic diazene synthesis from sterically hindered amines for deaminative functionalization |
| title_sort | catalytic diazene synthesis from sterically hindered amines for deaminative functionalization |
| url | https://doi.org/10.1038/s41467-025-61662-9 |
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