Reverse-engineering the FLT3-PI3K/AKT axis to enhance TILs function and improve prognosis in ovarian and cervical cancers

Reverse-engineering the FLT3-PI3K/AKT axis to enhance TILs function and improve prognosis in ovarian and cervical cancers

Abstract Background Ovarian cancers (OC) and cervical cancers (CC) have poor survival rates. Tumor-infiltrating lymphocytes (TILs) play a pivotal role in prognosis, but shared immune mechanisms remain elusive. Methods We integrated single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (...

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Bibliographic Details
Main Authors: Feng Hao, Zhang Yan, Luo Shen, Wang Hui, Qiu Ling, Yang Xiaoyu, Jiang Hua
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Ovarian Research
Subjects:
FLT3
PI3K/AKT pathway
Tumor-infiltrating lymphocytes (TILs)
Ovarian cancer
Cervical cancer
Spatial transcriptomics
Online Access:https://doi.org/10.1186/s13048-025-01592-8
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