TRIM21 Promotes Tumor Growth and Gemcitabine Resistance in Pancreatic Cancer by Inhibiting EPHX1‐Mediated Arachidonic Acid Metabolism

TRIM21 Promotes Tumor Growth and Gemcitabine Resistance in Pancreatic Cancer by Inhibiting EPHX1‐Mediated Arachidonic Acid Metabolism

Abstract Pancreatic cancer (PC) progresses rapidly, and gemcitabine‐based chemotherapy has brought only limited efficacy. Identifying key drivers and therapeutic targets holds significant clinical value. In this study, through comprehensive analysis of multiple PC databases, this work identifies TRI...

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Bibliographic Details
Main Authors: Xiaona Fan, Yisheng Dai, Chuanfeng Mo, Hengzhen Li, Xindi Luan, Bojun Wang, Jiani Yang, Guangtao Jiao, XiaoLin Lu, Zhuo Chen, Yuanyu Liao, Ling Qu, Huike Yang, Changjie Lou, Chao Liu, Zhiwei Li
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Advanced Science
Subjects:
arachidonic acid metabolism
EPHX1
pancreatic cancer
TRIM21
ubiquitination
Online Access:https://doi.org/10.1002/advs.202413674
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