Taurine-mediated metabolic immune crosstalk indicates and promotes immunosuppression with anti-PD-1 resistance in bladder cancer

Taurine-mediated metabolic immune crosstalk indicates and promotes immunosuppression with anti-PD-1 resistance in bladder cancer

BackgroundBladder cancer (BLCA) remains heavily dependent on bacillus Calmette-Guérin (BCG) therapy due to the profound heterogeneity of its tumor microenvironment (TME) and deregulated metabolic landscapes. Taurine metabolism (TM) is a pivotal axis in BLCA, exhibiting dual roles in tumor progressio...

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Bibliographic Details
Main Authors: Zhengfang Liang, Fengwei Nong, Zhenjie Li, Runmin Chen, Haoxu Zhao, Yongping Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
bladder cancer
spatial transcriptomics
taurine
CAFs
anti-PD-1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1618439/full
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