Population pharmacokinetic model of high-dose methotrexate in Chinese patients with intracranial germ cell tumors

Population pharmacokinetic model of high-dose methotrexate in Chinese patients with intracranial germ cell tumors

This study aims to investigate the pharmacokinetics of methotrexate (MTX) in Chinese patients with intracranial germ cell tumors (iGCTs) and to develop a robust population pharmacokinetic (PPK) model. A two-compartment model with an exponential inter-individual variability and a proportional residua...

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Bibliographic Details
Main Authors: Jiashu Zhao, Ruoyun Wu, Sitian Zhang, Qian Lu, Ruitao Wang, Yingjun He, Zhigang Zhao, Shenghui Mei
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
methotrexate
intracranial germ cell tumors
population pharmacokinetic model
nonlinear mixed-effects modeling
bleomycin
bilirubin
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1548203/full
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