Nicotine dependence is associated with an increased risk of developing chronic, non-communicable inflammatory disease: a large-scale retrospective cohort study
IntroductionChronic, non-communicable inflammatory diseases (CIDs) affect a large portion of the population, imposing a significant morbidity, encompassing a substantial mortality. Thus, they are a major medical burden with a high unmet need. CIDs develop over the span of several years, and the risk...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1429297/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823856571353923584 |
|---|---|
| author | Khalaf Kridin Khalaf Kridin Khalaf Kridin Cristian Papara Katja Bieber David A. De Luca Jan Philipp Klein Marlene A. Ludwig Philip Curman Philip Curman Philip Curman Philip Curman Artem Vorobyev Astrid Dempfle Ralf J. Ludwig |
| author_facet | Khalaf Kridin Khalaf Kridin Khalaf Kridin Cristian Papara Katja Bieber David A. De Luca Jan Philipp Klein Marlene A. Ludwig Philip Curman Philip Curman Philip Curman Philip Curman Artem Vorobyev Astrid Dempfle Ralf J. Ludwig |
| author_sort | Khalaf Kridin |
| collection | DOAJ |
| description | IntroductionChronic, non-communicable inflammatory diseases (CIDs) affect a large portion of the population, imposing a significant morbidity, encompassing a substantial mortality. Thus, they are a major medical burden with a high unmet need. CIDs develop over the span of several years, and the risk of developing CIDs has been linked to genetic and environmental factors. Thus, modification of environmental factors is a promising approach for the prevention of CIDs. Among modifiable environmental factors that have been linked to the CID risk is nicotine dependence. However, for only few CIDs, compelling evidence suggests that nicotine dependence increases (e.g., rheumatoid arthritis and asthma) or decreases (e.g., pemphigus) the CID risk. For most CIDs, there are inconsistent, scant, or no reports on the risk of CID associated with nicotine dependence.MethodsTo address this gap, we leveraged TriNetX, analyzing data from over 120 million electronic health records (EHRs). Using propensity score matching (PSM) to control for age, sex, ethnicity, and other CID risk factors, we contrasted the risk of developing any or any of the 38 CIDs in 881,192 EHRs from individuals with nicotine dependence to PSM-matched unexposed counterparts.ResultsThe analytical pipeline was validated by demonstrating an increased risk of individuals exposed to nicotine dependence for subsequent diagnosis of myocardial infarction, malignant neoplasm of the lung, and chronic obstructive pulmonary disease. Overall, 16.8% of individuals with nicotine dependence developed CIDs, compared to 9.6% of individuals not exposed to nicotine dependence (hazard ratio 2.12, confidence interval 2.10–2.14, p < 0.0001). Investigating single CIDs, nicotine dependence imposed increased risks for 23 of the 38 investigated diseases, i.e., dermatomyositis, granulomatosis with polyangiitis, pyoderma gangrenosum, and immune thrombocytopenic purpura. The sex-stratified analysis revealed few sex-specific differences in CID risk.DiscussionOur study emphasizes the importance of preventive measures targeting nicotine addiction to reduce the global burden of CIDs. |
| format | Article |
| id | doaj-art-3b0a814cae3d43b5a4df1a986f1e64a9 |
| institution | Kabale University |
| issn | 1664-0640 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj-art-3b0a814cae3d43b5a4df1a986f1e64a92025-02-12T07:25:43ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-02-011610.3389/fpsyt.2025.14292971429297Nicotine dependence is associated with an increased risk of developing chronic, non-communicable inflammatory disease: a large-scale retrospective cohort studyKhalaf Kridin0Khalaf Kridin1Khalaf Kridin2Cristian Papara3Katja Bieber4David A. De Luca5Jan Philipp Klein6Marlene A. Ludwig7Philip Curman8Philip Curman9Philip Curman10Philip Curman11Artem Vorobyev12Astrid Dempfle13Ralf J. Ludwig14Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, GermanyAzrieli Faculty of Medicine, Bar-Ilan University, Safed, IsraelUnit of Dermatology and Skin Research Laboratory, Galilee Medical Center, Nahariya, IsraelInstiture and Comprehensive Centre for Inflammation Medicine, University Hospital Schleswig-Holstein (UKSH), Lübeck, GermanyLübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, GermanyInstiture and Comprehensive Centre for Inflammation Medicine, University Hospital Schleswig-Holstein (UKSH), Lübeck, GermanyDepartment of Psychiatry, Psychosomatics and Psychotherapy, Lübeck University, Lübeck, GermanyIndependent Researcher, Groß Grönau, GermanyLübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, GermanyDermato-Venereology Clinic, Karolinska University Hospital, Stockholm, SwedenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenDepartment of Medicine Solna, Karolinska Institutet, Stockholm, Sweden0Department of Dermatology, University Hospital Schleswig-Holstein (UKSH), Lübeck, Germany1Institute of Medical Informatics and Statistics, Kiel University, Kiel, Germany0Department of Dermatology, University Hospital Schleswig-Holstein (UKSH), Lübeck, GermanyIntroductionChronic, non-communicable inflammatory diseases (CIDs) affect a large portion of the population, imposing a significant morbidity, encompassing a substantial mortality. Thus, they are a major medical burden with a high unmet need. CIDs develop over the span of several years, and the risk of developing CIDs has been linked to genetic and environmental factors. Thus, modification of environmental factors is a promising approach for the prevention of CIDs. Among modifiable environmental factors that have been linked to the CID risk is nicotine dependence. However, for only few CIDs, compelling evidence suggests that nicotine dependence increases (e.g., rheumatoid arthritis and asthma) or decreases (e.g., pemphigus) the CID risk. For most CIDs, there are inconsistent, scant, or no reports on the risk of CID associated with nicotine dependence.MethodsTo address this gap, we leveraged TriNetX, analyzing data from over 120 million electronic health records (EHRs). Using propensity score matching (PSM) to control for age, sex, ethnicity, and other CID risk factors, we contrasted the risk of developing any or any of the 38 CIDs in 881,192 EHRs from individuals with nicotine dependence to PSM-matched unexposed counterparts.ResultsThe analytical pipeline was validated by demonstrating an increased risk of individuals exposed to nicotine dependence for subsequent diagnosis of myocardial infarction, malignant neoplasm of the lung, and chronic obstructive pulmonary disease. Overall, 16.8% of individuals with nicotine dependence developed CIDs, compared to 9.6% of individuals not exposed to nicotine dependence (hazard ratio 2.12, confidence interval 2.10–2.14, p < 0.0001). Investigating single CIDs, nicotine dependence imposed increased risks for 23 of the 38 investigated diseases, i.e., dermatomyositis, granulomatosis with polyangiitis, pyoderma gangrenosum, and immune thrombocytopenic purpura. The sex-stratified analysis revealed few sex-specific differences in CID risk.DiscussionOur study emphasizes the importance of preventive measures targeting nicotine addiction to reduce the global burden of CIDs.https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1429297/fullnicotine dependencechronic inflammatory diseasesasthmalupusCOPDdermatomyositis |
| spellingShingle | Khalaf Kridin Khalaf Kridin Khalaf Kridin Cristian Papara Katja Bieber David A. De Luca Jan Philipp Klein Marlene A. Ludwig Philip Curman Philip Curman Philip Curman Philip Curman Artem Vorobyev Astrid Dempfle Ralf J. Ludwig Nicotine dependence is associated with an increased risk of developing chronic, non-communicable inflammatory disease: a large-scale retrospective cohort study Frontiers in Psychiatry nicotine dependence chronic inflammatory diseases asthma lupus COPD dermatomyositis |
| title | Nicotine dependence is associated with an increased risk of developing chronic, non-communicable inflammatory disease: a large-scale retrospective cohort study |
| title_full | Nicotine dependence is associated with an increased risk of developing chronic, non-communicable inflammatory disease: a large-scale retrospective cohort study |
| title_fullStr | Nicotine dependence is associated with an increased risk of developing chronic, non-communicable inflammatory disease: a large-scale retrospective cohort study |
| title_full_unstemmed | Nicotine dependence is associated with an increased risk of developing chronic, non-communicable inflammatory disease: a large-scale retrospective cohort study |
| title_short | Nicotine dependence is associated with an increased risk of developing chronic, non-communicable inflammatory disease: a large-scale retrospective cohort study |
| title_sort | nicotine dependence is associated with an increased risk of developing chronic non communicable inflammatory disease a large scale retrospective cohort study |
| topic | nicotine dependence chronic inflammatory diseases asthma lupus COPD dermatomyositis |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1429297/full |
| work_keys_str_mv | AT khalafkridin nicotinedependenceisassociatedwithanincreasedriskofdevelopingchronicnoncommunicableinflammatorydiseasealargescaleretrospectivecohortstudy AT khalafkridin nicotinedependenceisassociatedwithanincreasedriskofdevelopingchronicnoncommunicableinflammatorydiseasealargescaleretrospectivecohortstudy AT khalafkridin nicotinedependenceisassociatedwithanincreasedriskofdevelopingchronicnoncommunicableinflammatorydiseasealargescaleretrospectivecohortstudy AT cristianpapara nicotinedependenceisassociatedwithanincreasedriskofdevelopingchronicnoncommunicableinflammatorydiseasealargescaleretrospectivecohortstudy AT katjabieber nicotinedependenceisassociatedwithanincreasedriskofdevelopingchronicnoncommunicableinflammatorydiseasealargescaleretrospectivecohortstudy AT davidadeluca nicotinedependenceisassociatedwithanincreasedriskofdevelopingchronicnoncommunicableinflammatorydiseasealargescaleretrospectivecohortstudy AT janphilippklein nicotinedependenceisassociatedwithanincreasedriskofdevelopingchronicnoncommunicableinflammatorydiseasealargescaleretrospectivecohortstudy AT marlenealudwig nicotinedependenceisassociatedwithanincreasedriskofdevelopingchronicnoncommunicableinflammatorydiseasealargescaleretrospectivecohortstudy AT philipcurman nicotinedependenceisassociatedwithanincreasedriskofdevelopingchronicnoncommunicableinflammatorydiseasealargescaleretrospectivecohortstudy AT philipcurman nicotinedependenceisassociatedwithanincreasedriskofdevelopingchronicnoncommunicableinflammatorydiseasealargescaleretrospectivecohortstudy AT philipcurman nicotinedependenceisassociatedwithanincreasedriskofdevelopingchronicnoncommunicableinflammatorydiseasealargescaleretrospectivecohortstudy AT philipcurman nicotinedependenceisassociatedwithanincreasedriskofdevelopingchronicnoncommunicableinflammatorydiseasealargescaleretrospectivecohortstudy AT artemvorobyev nicotinedependenceisassociatedwithanincreasedriskofdevelopingchronicnoncommunicableinflammatorydiseasealargescaleretrospectivecohortstudy AT astriddempfle nicotinedependenceisassociatedwithanincreasedriskofdevelopingchronicnoncommunicableinflammatorydiseasealargescaleretrospectivecohortstudy AT ralfjludwig nicotinedependenceisassociatedwithanincreasedriskofdevelopingchronicnoncommunicableinflammatorydiseasealargescaleretrospectivecohortstudy |