Arterial Stiffness in Nonhypertensive Type 2 Diabetes Patients in Ghana
Background. Increased arterial stiffness is an independent cardiovascular risk factor in diabetes patients and general population. However, the contribution of diabetes to arterial stiffness is often masked by coexistent obesity and hypertension. In this study, we assessed arterial stiffness in nonh...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/6107572 |
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| author | Kwame Yeboah Daniel A. Antwi Ben Gyan |
| author_facet | Kwame Yeboah Daniel A. Antwi Ben Gyan |
| author_sort | Kwame Yeboah |
| collection | DOAJ |
| description | Background. Increased arterial stiffness is an independent cardiovascular risk factor in diabetes patients and general population. However, the contribution of diabetes to arterial stiffness is often masked by coexistent obesity and hypertension. In this study, we assessed arterial stiffness in nonhypertensive, nonobese type 2 diabetes (T2DM) patients in Ghana. Methods. In case-control design, 166 nonhypertensive, nonobese participants, comprising 96 T2DM patients and 70 nondiabetes controls, were recruited. Peripheral and central blood pressure (BP) indices were measured, and arterial stiffness was assessed as aortic pulse wave velocity (PWVao), augmentation index (AIx), cardioankle vascular index (CAVI), and heart-ankle pulse wave velocity (haPWV). Results. With similar peripheral and central BP indices, T2DM patients had higher PWVao (8.3 ± 1 versus 7.8 ± 1.3, p=0.044) and CAVI (7.9 ± 1.2 versus 6.9 ± 0.7, p=0.021) than nondiabetic control. AIx and haPWV were similar between T2DM and nondiabetic controls. Multiple regression models showed that, in the entire study participants, the major determinants of PWVao were diabetes status, age, gender, systolic BP, and previous smoking status (β = 0.22, 0.36, 0.48, 0.21, and 0.25, resp.; all p<0.05); the determinants of CAVI were diabetes status, age, BMI, heart rate, HbA1c, total cholesterol, HDL cholesterol, and previous smoking status (β = 0.21, 0.38, 0.2, 0.18, 0.24. 0.2, −0.19, and 0.2, resp.; all p<0.05). Conclusion. Our findings suggest that nonhypertensive, nonobese T2DM patients have increased arterial stiffness without appreciable increase in peripheral and central pressure indices. |
| format | Article |
| id | doaj-art-3b0667096b4b4514be39c7a9c4d8db4d |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-3b0667096b4b4514be39c7a9c4d8db4d2025-02-03T06:05:22ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/61075726107572Arterial Stiffness in Nonhypertensive Type 2 Diabetes Patients in GhanaKwame Yeboah0Daniel A. Antwi1Ben Gyan2Department of Physiology, School of Allied & Biomedical Sciences, University of Ghana, Accra, GhanaDepartment of Physiology, School of Allied & Biomedical Sciences, University of Ghana, Accra, GhanaDepartment of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, GhanaBackground. Increased arterial stiffness is an independent cardiovascular risk factor in diabetes patients and general population. However, the contribution of diabetes to arterial stiffness is often masked by coexistent obesity and hypertension. In this study, we assessed arterial stiffness in nonhypertensive, nonobese type 2 diabetes (T2DM) patients in Ghana. Methods. In case-control design, 166 nonhypertensive, nonobese participants, comprising 96 T2DM patients and 70 nondiabetes controls, were recruited. Peripheral and central blood pressure (BP) indices were measured, and arterial stiffness was assessed as aortic pulse wave velocity (PWVao), augmentation index (AIx), cardioankle vascular index (CAVI), and heart-ankle pulse wave velocity (haPWV). Results. With similar peripheral and central BP indices, T2DM patients had higher PWVao (8.3 ± 1 versus 7.8 ± 1.3, p=0.044) and CAVI (7.9 ± 1.2 versus 6.9 ± 0.7, p=0.021) than nondiabetic control. AIx and haPWV were similar between T2DM and nondiabetic controls. Multiple regression models showed that, in the entire study participants, the major determinants of PWVao were diabetes status, age, gender, systolic BP, and previous smoking status (β = 0.22, 0.36, 0.48, 0.21, and 0.25, resp.; all p<0.05); the determinants of CAVI were diabetes status, age, BMI, heart rate, HbA1c, total cholesterol, HDL cholesterol, and previous smoking status (β = 0.21, 0.38, 0.2, 0.18, 0.24. 0.2, −0.19, and 0.2, resp.; all p<0.05). Conclusion. Our findings suggest that nonhypertensive, nonobese T2DM patients have increased arterial stiffness without appreciable increase in peripheral and central pressure indices.http://dx.doi.org/10.1155/2016/6107572 |
| spellingShingle | Kwame Yeboah Daniel A. Antwi Ben Gyan Arterial Stiffness in Nonhypertensive Type 2 Diabetes Patients in Ghana International Journal of Endocrinology |
| title | Arterial Stiffness in Nonhypertensive Type 2 Diabetes Patients in Ghana |
| title_full | Arterial Stiffness in Nonhypertensive Type 2 Diabetes Patients in Ghana |
| title_fullStr | Arterial Stiffness in Nonhypertensive Type 2 Diabetes Patients in Ghana |
| title_full_unstemmed | Arterial Stiffness in Nonhypertensive Type 2 Diabetes Patients in Ghana |
| title_short | Arterial Stiffness in Nonhypertensive Type 2 Diabetes Patients in Ghana |
| title_sort | arterial stiffness in nonhypertensive type 2 diabetes patients in ghana |
| url | http://dx.doi.org/10.1155/2016/6107572 |
| work_keys_str_mv | AT kwameyeboah arterialstiffnessinnonhypertensivetype2diabetespatientsinghana AT danielaantwi arterialstiffnessinnonhypertensivetype2diabetespatientsinghana AT bengyan arterialstiffnessinnonhypertensivetype2diabetespatientsinghana |