Risk Factors for Nonalcoholic Fatty Liver Disease with Different Insulin Resistance in a Nonobese Chinese Population
Purposes. The aim of this study is to identify the risk factors of nonobese nonalcoholic fatty liver disease (NAFLD) individuals under different insulin resistance status. Methods. This cross-sectional study was conducted at the Medical Center of Beijing Chaoyang Hospital affiliated with Capital Med...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2022/9060405 |
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| author | Xiaojuan Wu Ying Wang Yumei Jia Jia Liu Guang Wang |
| author_facet | Xiaojuan Wu Ying Wang Yumei Jia Jia Liu Guang Wang |
| author_sort | Xiaojuan Wu |
| collection | DOAJ |
| description | Purposes. The aim of this study is to identify the risk factors of nonobese nonalcoholic fatty liver disease (NAFLD) individuals under different insulin resistance status. Methods. This cross-sectional study was conducted at the Medical Center of Beijing Chaoyang Hospital affiliated with Capital Medical University. NAFLD was diagnosed based upon ultrasonographic findings consistent with fatty liver disease. Results. A total of 1257 nonobese adults (625 non-NAFLD and 632 nonobese NAFLD) with body mass index (BMI) 18.5-24.9 kg/m2 were enrolled in the study. And all patients were divided into homeostasis model assessment of insulin resistance HOMA−IR>1 group and HOMA−IR≤1 group. When all the variables were adjusted in both the HOMA−IR>1 group and HOMA−IR≤1 group, older age (>50 years), higher BMI (23.0-24.9 kg/m2), higher AST (>18 U/L), higher TG (>0.9 mmol/L), higher GLU (>5.25 mmol/L), and higher HbA1C (>5.5%) were associated with higher risks of nonobese NAFLD. In patients with HOMA−IR>1, lower homeostatic model assessment of β-cell function (HOMA-β) (<47.1%) (OR, 7.460, 95% CI, 3.051-18.238, P<0.001) was associated with higher risks of nonobese NAFLD. Conclusions. Metabolic profiles (i.e., higher BMI, hyperglycemia, hypertriglyceridemia, and higher glycosylated hemoglobin) are risk factors of nonobese NAFLD, regardless of insulin resistance status. Decreased function of pancreatic β-cells may be the risk factor of nonobese NAFLD with insulin resistance, who should pay attention to further development of pancreatic β-cell dysfunction. |
| format | Article |
| id | doaj-art-3b059d7c2b9a40b9bd4ae351b38f0d0e |
| institution | Kabale University |
| issn | 2314-6753 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-3b059d7c2b9a40b9bd4ae351b38f0d0e2025-08-20T03:55:36ZengWileyJournal of Diabetes Research2314-67532022-01-01202210.1155/2022/9060405Risk Factors for Nonalcoholic Fatty Liver Disease with Different Insulin Resistance in a Nonobese Chinese PopulationXiaojuan Wu0Ying Wang1Yumei Jia2Jia Liu3Guang Wang4Department of EndocrinologyDepartment of Medical CenterDepartment of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyPurposes. The aim of this study is to identify the risk factors of nonobese nonalcoholic fatty liver disease (NAFLD) individuals under different insulin resistance status. Methods. This cross-sectional study was conducted at the Medical Center of Beijing Chaoyang Hospital affiliated with Capital Medical University. NAFLD was diagnosed based upon ultrasonographic findings consistent with fatty liver disease. Results. A total of 1257 nonobese adults (625 non-NAFLD and 632 nonobese NAFLD) with body mass index (BMI) 18.5-24.9 kg/m2 were enrolled in the study. And all patients were divided into homeostasis model assessment of insulin resistance HOMA−IR>1 group and HOMA−IR≤1 group. When all the variables were adjusted in both the HOMA−IR>1 group and HOMA−IR≤1 group, older age (>50 years), higher BMI (23.0-24.9 kg/m2), higher AST (>18 U/L), higher TG (>0.9 mmol/L), higher GLU (>5.25 mmol/L), and higher HbA1C (>5.5%) were associated with higher risks of nonobese NAFLD. In patients with HOMA−IR>1, lower homeostatic model assessment of β-cell function (HOMA-β) (<47.1%) (OR, 7.460, 95% CI, 3.051-18.238, P<0.001) was associated with higher risks of nonobese NAFLD. Conclusions. Metabolic profiles (i.e., higher BMI, hyperglycemia, hypertriglyceridemia, and higher glycosylated hemoglobin) are risk factors of nonobese NAFLD, regardless of insulin resistance status. Decreased function of pancreatic β-cells may be the risk factor of nonobese NAFLD with insulin resistance, who should pay attention to further development of pancreatic β-cell dysfunction.http://dx.doi.org/10.1155/2022/9060405 |
| spellingShingle | Xiaojuan Wu Ying Wang Yumei Jia Jia Liu Guang Wang Risk Factors for Nonalcoholic Fatty Liver Disease with Different Insulin Resistance in a Nonobese Chinese Population Journal of Diabetes Research |
| title | Risk Factors for Nonalcoholic Fatty Liver Disease with Different Insulin Resistance in a Nonobese Chinese Population |
| title_full | Risk Factors for Nonalcoholic Fatty Liver Disease with Different Insulin Resistance in a Nonobese Chinese Population |
| title_fullStr | Risk Factors for Nonalcoholic Fatty Liver Disease with Different Insulin Resistance in a Nonobese Chinese Population |
| title_full_unstemmed | Risk Factors for Nonalcoholic Fatty Liver Disease with Different Insulin Resistance in a Nonobese Chinese Population |
| title_short | Risk Factors for Nonalcoholic Fatty Liver Disease with Different Insulin Resistance in a Nonobese Chinese Population |
| title_sort | risk factors for nonalcoholic fatty liver disease with different insulin resistance in a nonobese chinese population |
| url | http://dx.doi.org/10.1155/2022/9060405 |
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