Association between neuroinflammation, vascular risk, and biomarkers in Alzheimer’s disease
Objective To investigate the association between neuroinflammation, vascular risk, and biomarkers in Alzheimer’s disease (AD). Methods A total of 1 079 individuals without AD were selected as subjects from the China Alzheimer’s Biomarker and Lifestyle study cohort, and Framingham General Cardiovascu...
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Editorial Office of Journal of Precision Medicine
2025-08-01
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| Series: | 精准医学杂志 |
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| Online Access: | https://jpmed.qdu.edu.cn/fileup/2096-529X/PDF/1754471563770-418729497.pdf |
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| author | CHEN Yanming, HU Heying, CUI Ruiping, HU Hao, TAN Chenchen, TAN Lan |
| author_facet | CHEN Yanming, HU Heying, CUI Ruiping, HU Hao, TAN Chenchen, TAN Lan |
| author_sort | CHEN Yanming, HU Heying, CUI Ruiping, HU Hao, TAN Chenchen, TAN Lan |
| collection | DOAJ |
| description | Objective To investigate the association between neuroinflammation, vascular risk, and biomarkers in Alzheimer’s disease (AD). Methods A total of 1 079 individuals without AD were selected as subjects from the China Alzheimer’s Biomarker and Lifestyle study cohort, and Framingham General Cardiovascular Risk Score (FGCRS) was used to assess the vascular risk of the subjects. The multiple linear regression model was used to investigate the correlation of FGCRS with AD biomarkers in cerebrospinal fluid (CSF) (β-amyloid 42 [Aβ42], β-amyloid 40 [Aβ40], phosphorylated tau [P-tau], total tau [T-tau], Aβ42/Aβ40 ratio, T-tau/Aβ42 ratio, and P-tau/Aβ42 ratio], neuroinflammatory factors in CSF (soluble triggering receptor expressed on myeloid cells 2 [sTREM2] and progranulin [PGRN]), and peripheral blood inflammatory cells (white blood cell count [WBC], neutrophil count [NEU], lymphocyte count [LY], monocyte count [MONO], and neutrophil-to-lymphocyte ratio [NLR]). Mediation models were constructed with sTREM2 and PGRN as mediators to investigate the mediating effect of neuroinflammatory factors between vascular risk and AD biomarkers. Results FGCRS was positively correlated with the levels of Aβ42, Aβ40, P-tau, and T-tau in CSF (β=0.066-0.242,t=2.020-7.928,P<0.05), and it was also positively correlated with the levels of sTREM2 and PGRN in CSF and the levels of WBC, NEU, NLR, and MONO in peripheral blood (β=0.120-0.228,t=3.285-5.705,P<0.05). PGRN and sTREM2 mediated the association between FGCRS and AD biomarkers in CSF (Aβ40, P-tau, T-tau, and Aβ42), with a mediation ratio of 26.75%-81.82% for sTREM2 and 9.66%-31.03% for PGRN. Conclusion The increase in vascular risk may influence the levels of AD biomarkers in CSF by increasing the levels of neuroinflammatory factors in CSF, thereby promoting the development and progression of AD. |
| format | Article |
| id | doaj-art-3b045ffff6844244a0d4645fa99e781b |
| institution | Kabale University |
| issn | 2096-529X |
| language | zho |
| publishDate | 2025-08-01 |
| publisher | Editorial Office of Journal of Precision Medicine |
| record_format | Article |
| series | 精准医学杂志 |
| spelling | doaj-art-3b045ffff6844244a0d4645fa99e781b2025-08-20T04:00:28ZzhoEditorial Office of Journal of Precision Medicine精准医学杂志2096-529X2025-08-0140433133510.13362/j.jpmed.202540070Association between neuroinflammation, vascular risk, and biomarkers in Alzheimer’s diseaseCHEN Yanming, HU Heying, CUI Ruiping, HU Hao, TAN Chenchen, TAN Lan0Qingdao Medical College of Qingdao University, Qingdao 266071, ChinaObjective To investigate the association between neuroinflammation, vascular risk, and biomarkers in Alzheimer’s disease (AD). Methods A total of 1 079 individuals without AD were selected as subjects from the China Alzheimer’s Biomarker and Lifestyle study cohort, and Framingham General Cardiovascular Risk Score (FGCRS) was used to assess the vascular risk of the subjects. The multiple linear regression model was used to investigate the correlation of FGCRS with AD biomarkers in cerebrospinal fluid (CSF) (β-amyloid 42 [Aβ42], β-amyloid 40 [Aβ40], phosphorylated tau [P-tau], total tau [T-tau], Aβ42/Aβ40 ratio, T-tau/Aβ42 ratio, and P-tau/Aβ42 ratio], neuroinflammatory factors in CSF (soluble triggering receptor expressed on myeloid cells 2 [sTREM2] and progranulin [PGRN]), and peripheral blood inflammatory cells (white blood cell count [WBC], neutrophil count [NEU], lymphocyte count [LY], monocyte count [MONO], and neutrophil-to-lymphocyte ratio [NLR]). Mediation models were constructed with sTREM2 and PGRN as mediators to investigate the mediating effect of neuroinflammatory factors between vascular risk and AD biomarkers. Results FGCRS was positively correlated with the levels of Aβ42, Aβ40, P-tau, and T-tau in CSF (β=0.066-0.242,t=2.020-7.928,P<0.05), and it was also positively correlated with the levels of sTREM2 and PGRN in CSF and the levels of WBC, NEU, NLR, and MONO in peripheral blood (β=0.120-0.228,t=3.285-5.705,P<0.05). PGRN and sTREM2 mediated the association between FGCRS and AD biomarkers in CSF (Aβ40, P-tau, T-tau, and Aβ42), with a mediation ratio of 26.75%-81.82% for sTREM2 and 9.66%-31.03% for PGRN. Conclusion The increase in vascular risk may influence the levels of AD biomarkers in CSF by increasing the levels of neuroinflammatory factors in CSF, thereby promoting the development and progression of AD.https://jpmed.qdu.edu.cn/fileup/2096-529X/PDF/1754471563770-418729497.pdfalzheimer disease|inflammation|risk factors|vascular risk|amyloid|progranulins|blood cell count|cerebrospinal fluid|soluble triggering receptor expressed on myeloid cells 2|biomarkers |
| spellingShingle | CHEN Yanming, HU Heying, CUI Ruiping, HU Hao, TAN Chenchen, TAN Lan Association between neuroinflammation, vascular risk, and biomarkers in Alzheimer’s disease 精准医学杂志 alzheimer disease|inflammation|risk factors|vascular risk|amyloid|progranulins|blood cell count|cerebrospinal fluid|soluble triggering receptor expressed on myeloid cells 2|biomarkers |
| title | Association between neuroinflammation, vascular risk, and biomarkers in Alzheimer’s disease |
| title_full | Association between neuroinflammation, vascular risk, and biomarkers in Alzheimer’s disease |
| title_fullStr | Association between neuroinflammation, vascular risk, and biomarkers in Alzheimer’s disease |
| title_full_unstemmed | Association between neuroinflammation, vascular risk, and biomarkers in Alzheimer’s disease |
| title_short | Association between neuroinflammation, vascular risk, and biomarkers in Alzheimer’s disease |
| title_sort | association between neuroinflammation vascular risk and biomarkers in alzheimer s disease |
| topic | alzheimer disease|inflammation|risk factors|vascular risk|amyloid|progranulins|blood cell count|cerebrospinal fluid|soluble triggering receptor expressed on myeloid cells 2|biomarkers |
| url | https://jpmed.qdu.edu.cn/fileup/2096-529X/PDF/1754471563770-418729497.pdf |
| work_keys_str_mv | AT chenyanminghuheyingcuiruipinghuhaotanchenchentanlan associationbetweenneuroinflammationvascularriskandbiomarkersinalzheimersdisease |