PPARα Ligands as Antitumorigenic and Antiangiogenic Agents
Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear receptor family of ligand-activated transcription factors. This subfamily is composed of three members—PPARα, PPARδ, and PPARγ—that differ in their cell and tissue distribution as well as in their target genes. PPARα is abunda...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2008/906542 |
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| author | Ambra Pozzi Jorge H. Capdevila |
| author_facet | Ambra Pozzi Jorge H. Capdevila |
| author_sort | Ambra Pozzi |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear receptor family of ligand-activated transcription factors. This subfamily is composed of three members—PPARα, PPARδ, and PPARγ—that differ in their cell and tissue distribution as well as in their target genes. PPARα is abundantly expressed in liver, brown adipose tissue, kidney, intestine, heart, and skeletal muscle; and its ligands have been used to treat diseases such as obesity and diabetes. The recent finding that members of the PPAR family, including the PPARα, are expressed by tumor and endothelial cells together with the observation that PPAR ligands regulate cell growth, survival, migration, and invasion, suggested that PPARs also play a role in cancer. In this review, we focus on the contribution of PPARα to tumor and endothelial cell functions and provide compelling evidence that PPARα can be viewed as a new class of ligand activated tumor “suppressor” gene with antiangiogenic and antitumorigenic activities. Given that PPAR ligands are currently used in medicine as hypolipidemic drugs with excellent tolerance and limited toxicity, PPARα activation might offer a novel and potentially low-toxic approach for the treatment of tumor-associated angiogenesis and cancer. |
| format | Article |
| id | doaj-art-3afcfdadcc5743dd85c2ef904e44df0a |
| institution | OA Journals |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-3afcfdadcc5743dd85c2ef904e44df0a2025-08-20T02:08:15ZengWileyPPAR Research1687-47571687-47652008-01-01200810.1155/2008/906542906542PPARα Ligands as Antitumorigenic and Antiangiogenic AgentsAmbra Pozzi0Jorge H. Capdevila1Department of Medicine, Division of Nephrology and Hypertension, S-3223 Medical Center North, Vanderbilt University, Nashville, TN 37232, USADepartment of Medicine, Division of Nephrology and Hypertension, S-3223 Medical Center North, Vanderbilt University, Nashville, TN 37232, USAPeroxisome proliferator-activated receptors (PPARs) belong to the nuclear receptor family of ligand-activated transcription factors. This subfamily is composed of three members—PPARα, PPARδ, and PPARγ—that differ in their cell and tissue distribution as well as in their target genes. PPARα is abundantly expressed in liver, brown adipose tissue, kidney, intestine, heart, and skeletal muscle; and its ligands have been used to treat diseases such as obesity and diabetes. The recent finding that members of the PPAR family, including the PPARα, are expressed by tumor and endothelial cells together with the observation that PPAR ligands regulate cell growth, survival, migration, and invasion, suggested that PPARs also play a role in cancer. In this review, we focus on the contribution of PPARα to tumor and endothelial cell functions and provide compelling evidence that PPARα can be viewed as a new class of ligand activated tumor “suppressor” gene with antiangiogenic and antitumorigenic activities. Given that PPAR ligands are currently used in medicine as hypolipidemic drugs with excellent tolerance and limited toxicity, PPARα activation might offer a novel and potentially low-toxic approach for the treatment of tumor-associated angiogenesis and cancer.http://dx.doi.org/10.1155/2008/906542 |
| spellingShingle | Ambra Pozzi Jorge H. Capdevila PPARα Ligands as Antitumorigenic and Antiangiogenic Agents PPAR Research |
| title | PPARα Ligands as Antitumorigenic and Antiangiogenic Agents |
| title_full | PPARα Ligands as Antitumorigenic and Antiangiogenic Agents |
| title_fullStr | PPARα Ligands as Antitumorigenic and Antiangiogenic Agents |
| title_full_unstemmed | PPARα Ligands as Antitumorigenic and Antiangiogenic Agents |
| title_short | PPARα Ligands as Antitumorigenic and Antiangiogenic Agents |
| title_sort | pparα ligands as antitumorigenic and antiangiogenic agents |
| url | http://dx.doi.org/10.1155/2008/906542 |
| work_keys_str_mv | AT ambrapozzi pparaligandsasantitumorigenicandantiangiogenicagents AT jorgehcapdevila pparaligandsasantitumorigenicandantiangiogenicagents |