Consecutive mechanical-force-induced electron transfer for reduction of aryl halides with high reduction potentials
Abstract Mechanical-force-induced redox catalysis has emerged as a green and expeditous approach in synthetic chemistry, relying on single-electron transfer from polarized piezoelectric materials to substrates initiated by mechanical agitation. However, the piezoelectric potential generated can some...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-60459-0 |
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| author | Xiaohong Wang Xiaochun He Xuemei Zhang Qingqing Wang Qian Huang Ruiling Qu Zhong Lian |
| author_facet | Xiaohong Wang Xiaochun He Xuemei Zhang Qingqing Wang Qian Huang Ruiling Qu Zhong Lian |
| author_sort | Xiaohong Wang |
| collection | DOAJ |
| description | Abstract Mechanical-force-induced redox catalysis has emerged as a green and expeditous approach in synthetic chemistry, relying on single-electron transfer from polarized piezoelectric materials to substrates initiated by mechanical agitation. However, the piezoelectric potential generated can sometimes be insufficient to activate the electron transfer process, similar to the limitations observed in photocatalytic reactions. In this work, we introduce a catalytic strategy employing a consecutive mechanical-force-induced electron transfer (ConMET) strategy. This strategy uses piezoelectric materials as mechanochemical redox catalysts with 9-phenyl-dihydroacridine as a sacrificial electron donor, enabling efficient consecutive electron transfer. Our method effectively reduces aryl iodides, bromides, and even electron-rich aryl chlorides, which possess reduction potentials as high as −2.8 V (vs. SCE), leading to the formation of aryl radicals. Ultimately, this strategy facilitates anti-Markovnikov hydroarylation of alkenes and dehalogenative deuteration of aromatic halides under mild conditions. |
| format | Article |
| id | doaj-art-3afbf0e67cf849de916274334dc3029c |
| institution | OA Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-3afbf0e67cf849de916274334dc3029c2025-08-20T02:30:42ZengNature PortfolioNature Communications2041-17232025-06-011611910.1038/s41467-025-60459-0Consecutive mechanical-force-induced electron transfer for reduction of aryl halides with high reduction potentialsXiaohong Wang0Xiaochun He1Xuemei Zhang2Qingqing Wang3Qian Huang4Ruiling Qu5Zhong Lian6Department of Dermatology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan UniversityDepartment of Dermatology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan UniversityDepartment of Dermatology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan UniversityDepartment of Dermatology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan UniversityDepartment of Dermatology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan UniversityDepartment of Dermatology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan UniversityDepartment of Dermatology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan UniversityAbstract Mechanical-force-induced redox catalysis has emerged as a green and expeditous approach in synthetic chemistry, relying on single-electron transfer from polarized piezoelectric materials to substrates initiated by mechanical agitation. However, the piezoelectric potential generated can sometimes be insufficient to activate the electron transfer process, similar to the limitations observed in photocatalytic reactions. In this work, we introduce a catalytic strategy employing a consecutive mechanical-force-induced electron transfer (ConMET) strategy. This strategy uses piezoelectric materials as mechanochemical redox catalysts with 9-phenyl-dihydroacridine as a sacrificial electron donor, enabling efficient consecutive electron transfer. Our method effectively reduces aryl iodides, bromides, and even electron-rich aryl chlorides, which possess reduction potentials as high as −2.8 V (vs. SCE), leading to the formation of aryl radicals. Ultimately, this strategy facilitates anti-Markovnikov hydroarylation of alkenes and dehalogenative deuteration of aromatic halides under mild conditions.https://doi.org/10.1038/s41467-025-60459-0 |
| spellingShingle | Xiaohong Wang Xiaochun He Xuemei Zhang Qingqing Wang Qian Huang Ruiling Qu Zhong Lian Consecutive mechanical-force-induced electron transfer for reduction of aryl halides with high reduction potentials Nature Communications |
| title | Consecutive mechanical-force-induced electron transfer for reduction of aryl halides with high reduction potentials |
| title_full | Consecutive mechanical-force-induced electron transfer for reduction of aryl halides with high reduction potentials |
| title_fullStr | Consecutive mechanical-force-induced electron transfer for reduction of aryl halides with high reduction potentials |
| title_full_unstemmed | Consecutive mechanical-force-induced electron transfer for reduction of aryl halides with high reduction potentials |
| title_short | Consecutive mechanical-force-induced electron transfer for reduction of aryl halides with high reduction potentials |
| title_sort | consecutive mechanical force induced electron transfer for reduction of aryl halides with high reduction potentials |
| url | https://doi.org/10.1038/s41467-025-60459-0 |
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