EVALUATION OF THE ROLE OF HYPERHOMOCYSTEINEMIA AND POLYMORPHISM C677T GENE OF METHYLTETRAHYDROFOLATEREDUCTASE IN DEVELOPMENT OF CHRONIC HEART FAILURE
Aim. To study the influence of polymorphism of the gene methyltetrahydrofolate-reductase (MTHFR) — polymorhic locus С677Т, and level of homocysteine in blood plasma on the risk of development and course of chronic heart failure (CHF).Material and methods. Totally, 277 persons studied with CHF II-...
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«SILICEA-POLIGRAF» LLC
2016-08-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/443 |
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| author | A. T. Teplyakov E. N. Berezikova S. N. Shilov E. V. Grakova Yu. Yu. Torim A. V. Efremov А. А. Popova М. G. Pustosvetova А. Yu. Sabirova К. V. Kopieva |
| author_facet | A. T. Teplyakov E. N. Berezikova S. N. Shilov E. V. Grakova Yu. Yu. Torim A. V. Efremov А. А. Popova М. G. Pustosvetova А. Yu. Sabirova К. V. Kopieva |
| author_sort | A. T. Teplyakov |
| collection | DOAJ |
| description | Aim. To study the influence of polymorphism of the gene methyltetrahydrofolate-reductase (MTHFR) — polymorhic locus С677Т, and level of homocysteine in blood plasma on the risk of development and course of chronic heart failure (CHF).Material and methods. Totally, 277 persons studied with CHF II-IV functional classes (FC NYHA). The polymorphism С677Т of gene MTHFR studied via polymerase chain reaction. With the aim to reveal association of homocysteine with the course of CHF patients were selected by the results of year-long observation to 2 groups: with benign (n=49) and adverse (n=45) course. During the period the following was assessed: increase of symptoms and severity of CHF, hospitalizations rate, dynamics of the left ventricle ejection fraction.Results. Carriage of allele T and genotype T/T of polymorphic locus С677Т gene MTHFR was associated with more severe clinical picture of CHF. In CHF patients of II-IV FC homocysteine concentration in serum was significantly, 2-3 times, higher comparing to the controls, regardless of age. In adverse course group the level was highest comparing to benign course.Conclusion. The relation revealed of hyperhomocysteinemia with severity and character of CHF course. Assessment of homocysteine level in serum, and genetic polymorphism С677Т of gene MTHFR can be recommended for earlier prediction of severity of CHF. |
| format | Article |
| id | doaj-art-3afaf798a6cb46e5ad1efb470ab08eab |
| institution | Kabale University |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2016-08-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-3afaf798a6cb46e5ad1efb470ab08eab2025-08-20T03:35:44Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252016-08-01154222810.15829/1728-8800-2016-4-22-28350EVALUATION OF THE ROLE OF HYPERHOMOCYSTEINEMIA AND POLYMORPHISM C677T GENE OF METHYLTETRAHYDROFOLATEREDUCTASE IN DEVELOPMENT OF CHRONIC HEART FAILUREA. T. Teplyakov0E. N. Berezikova1S. N. Shilov2E. V. Grakova3Yu. Yu. Torim4A. V. Efremov5А. А. Popova6М. G. Pustosvetova7А. Yu. Sabirova8К. V. Kopieva9RI Cardiology. TomskNovosibirsk State Medical University of the Ministry of Health, NovosibirskNovosibirsk State Medical University of the Ministry of Health, NovosibirskRI Cardiology. TomskRI Cardiology. TomskNovosibirsk State Medical University of the Ministry of Health, NovosibirskNovosibirsk State Medical University of the Ministry of Health, NovosibirskNovosibirsk State Medical University of the Ministry of Health, NovosibirskNovosibirsk State Medical University of the Ministry of Health, NovosibirskRI Cardiology. TomskAim. To study the influence of polymorphism of the gene methyltetrahydrofolate-reductase (MTHFR) — polymorhic locus С677Т, and level of homocysteine in blood plasma on the risk of development and course of chronic heart failure (CHF).Material and methods. Totally, 277 persons studied with CHF II-IV functional classes (FC NYHA). The polymorphism С677Т of gene MTHFR studied via polymerase chain reaction. With the aim to reveal association of homocysteine with the course of CHF patients were selected by the results of year-long observation to 2 groups: with benign (n=49) and adverse (n=45) course. During the period the following was assessed: increase of symptoms and severity of CHF, hospitalizations rate, dynamics of the left ventricle ejection fraction.Results. Carriage of allele T and genotype T/T of polymorphic locus С677Т gene MTHFR was associated with more severe clinical picture of CHF. In CHF patients of II-IV FC homocysteine concentration in serum was significantly, 2-3 times, higher comparing to the controls, regardless of age. In adverse course group the level was highest comparing to benign course.Conclusion. The relation revealed of hyperhomocysteinemia with severity and character of CHF course. Assessment of homocysteine level in serum, and genetic polymorphism С677Т of gene MTHFR can be recommended for earlier prediction of severity of CHF.https://cardiovascular.elpub.ru/jour/article/view/443heart failurehomocysteinemethyltetrahydrofolatereductasepolymorphism с677т |
| spellingShingle | A. T. Teplyakov E. N. Berezikova S. N. Shilov E. V. Grakova Yu. Yu. Torim A. V. Efremov А. А. Popova М. G. Pustosvetova А. Yu. Sabirova К. V. Kopieva EVALUATION OF THE ROLE OF HYPERHOMOCYSTEINEMIA AND POLYMORPHISM C677T GENE OF METHYLTETRAHYDROFOLATEREDUCTASE IN DEVELOPMENT OF CHRONIC HEART FAILURE Кардиоваскулярная терапия и профилактика heart failure homocysteine methyltetrahydrofolatereductase polymorphism с677т |
| title | EVALUATION OF THE ROLE OF HYPERHOMOCYSTEINEMIA AND POLYMORPHISM C677T GENE OF METHYLTETRAHYDROFOLATEREDUCTASE IN DEVELOPMENT OF CHRONIC HEART FAILURE |
| title_full | EVALUATION OF THE ROLE OF HYPERHOMOCYSTEINEMIA AND POLYMORPHISM C677T GENE OF METHYLTETRAHYDROFOLATEREDUCTASE IN DEVELOPMENT OF CHRONIC HEART FAILURE |
| title_fullStr | EVALUATION OF THE ROLE OF HYPERHOMOCYSTEINEMIA AND POLYMORPHISM C677T GENE OF METHYLTETRAHYDROFOLATEREDUCTASE IN DEVELOPMENT OF CHRONIC HEART FAILURE |
| title_full_unstemmed | EVALUATION OF THE ROLE OF HYPERHOMOCYSTEINEMIA AND POLYMORPHISM C677T GENE OF METHYLTETRAHYDROFOLATEREDUCTASE IN DEVELOPMENT OF CHRONIC HEART FAILURE |
| title_short | EVALUATION OF THE ROLE OF HYPERHOMOCYSTEINEMIA AND POLYMORPHISM C677T GENE OF METHYLTETRAHYDROFOLATEREDUCTASE IN DEVELOPMENT OF CHRONIC HEART FAILURE |
| title_sort | evaluation of the role of hyperhomocysteinemia and polymorphism c677t gene of methyltetrahydrofolatereductase in development of chronic heart failure |
| topic | heart failure homocysteine methyltetrahydrofolatereductase polymorphism с677т |
| url | https://cardiovascular.elpub.ru/jour/article/view/443 |
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