Thermoresponsive NDP hydrogel embedded with MnO2 nanoparticles for postoperative antirecurrence therapy in pancreatic cancer
Abstract Surgical resection remains a potentially curative treatment option for pancreatic cancer (PC). However, the high rate of local tumor recurrence and poor prognosis severely limit its therapeutic efficacy. In this study, we report an injectable thermosensitive hydrogel platform (designated as...
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| Language: | English |
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-08431-2 |
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| author | Zhongxu Yuan Shuai Ma Liang Yan Man Xu Dongquan Liu Weicheng Wang Bowen Han Gan Chen Zhengguang Wang |
| author_facet | Zhongxu Yuan Shuai Ma Liang Yan Man Xu Dongquan Liu Weicheng Wang Bowen Han Gan Chen Zhengguang Wang |
| author_sort | Zhongxu Yuan |
| collection | DOAJ |
| description | Abstract Surgical resection remains a potentially curative treatment option for pancreatic cancer (PC). However, the high rate of local tumor recurrence and poor prognosis severely limit its therapeutic efficacy. In this study, we report an injectable thermosensitive hydrogel platform (designated as NDP@MnO2 hydrogel) that exhibits excellent biocompatibility, photothermal performance, and wet adhesion properties, specifically designed for precise post-operative therapy. This thermosensitive system innovatively combines shear-thinning injectability, dopamine-mediated tissue adhesion, and MnO2-enhanced photothermal ablation capabilities. By precisely targeting hyperthermia to the moist and irregular pancreatic resection margins during the sol-gel transition and subsequent exposure to an 808 nm laser, this approach can effectively and selectively eliminate residual tumor cells while minimizing collateral damage to adjacent healthy tissues. Notably, pre-clinical studies have demonstrated that this approach significantly reduces the locoregional recurrence rate in pancreatic cancer models, thereby offering a promising solution to the critical issue of postoperative recurrence. |
| format | Article |
| id | doaj-art-3af187fa32c54a82b4e40d963cec0a6f |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-3af187fa32c54a82b4e40d963cec0a6f2025-08-20T04:01:34ZengNature PortfolioScientific Reports2045-23222025-07-0115111710.1038/s41598-025-08431-2Thermoresponsive NDP hydrogel embedded with MnO2 nanoparticles for postoperative antirecurrence therapy in pancreatic cancerZhongxu Yuan0Shuai Ma1Liang Yan2Man Xu3Dongquan Liu4Weicheng Wang5Bowen Han6Gan Chen7Zhengguang Wang8Department of General Surgery, The First Affiliated Hospital of Anhui Medical UniversityGraduate School, Bengbu Medical UniversityDepartment of General Surgery, Anhui No. 2 Provincial People’s HospitalDepartment of General Surgery, Anhui No. 2 Provincial People’s HospitalDepartment of General Surgery, Anhui No. 2 Provincial People’s HospitalDepartment of General Surgery, Anhui No. 2 Provincial People’s HospitalDepartment of General Surgery, Anhui No. 2 Provincial People’s HospitalDepartment of General Surgery, Anhui No. 2 Provincial People’s HospitalDepartment of General Surgery, The First Affiliated Hospital of Anhui Medical UniversityAbstract Surgical resection remains a potentially curative treatment option for pancreatic cancer (PC). However, the high rate of local tumor recurrence and poor prognosis severely limit its therapeutic efficacy. In this study, we report an injectable thermosensitive hydrogel platform (designated as NDP@MnO2 hydrogel) that exhibits excellent biocompatibility, photothermal performance, and wet adhesion properties, specifically designed for precise post-operative therapy. This thermosensitive system innovatively combines shear-thinning injectability, dopamine-mediated tissue adhesion, and MnO2-enhanced photothermal ablation capabilities. By precisely targeting hyperthermia to the moist and irregular pancreatic resection margins during the sol-gel transition and subsequent exposure to an 808 nm laser, this approach can effectively and selectively eliminate residual tumor cells while minimizing collateral damage to adjacent healthy tissues. Notably, pre-clinical studies have demonstrated that this approach significantly reduces the locoregional recurrence rate in pancreatic cancer models, thereby offering a promising solution to the critical issue of postoperative recurrence.https://doi.org/10.1038/s41598-025-08431-2HydrogelPhotothermal therapyPancreatic cancerPostoperative recurrence |
| spellingShingle | Zhongxu Yuan Shuai Ma Liang Yan Man Xu Dongquan Liu Weicheng Wang Bowen Han Gan Chen Zhengguang Wang Thermoresponsive NDP hydrogel embedded with MnO2 nanoparticles for postoperative antirecurrence therapy in pancreatic cancer Scientific Reports Hydrogel Photothermal therapy Pancreatic cancer Postoperative recurrence |
| title | Thermoresponsive NDP hydrogel embedded with MnO2 nanoparticles for postoperative antirecurrence therapy in pancreatic cancer |
| title_full | Thermoresponsive NDP hydrogel embedded with MnO2 nanoparticles for postoperative antirecurrence therapy in pancreatic cancer |
| title_fullStr | Thermoresponsive NDP hydrogel embedded with MnO2 nanoparticles for postoperative antirecurrence therapy in pancreatic cancer |
| title_full_unstemmed | Thermoresponsive NDP hydrogel embedded with MnO2 nanoparticles for postoperative antirecurrence therapy in pancreatic cancer |
| title_short | Thermoresponsive NDP hydrogel embedded with MnO2 nanoparticles for postoperative antirecurrence therapy in pancreatic cancer |
| title_sort | thermoresponsive ndp hydrogel embedded with mno2 nanoparticles for postoperative antirecurrence therapy in pancreatic cancer |
| topic | Hydrogel Photothermal therapy Pancreatic cancer Postoperative recurrence |
| url | https://doi.org/10.1038/s41598-025-08431-2 |
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