Alteration of serotonin release response in the central nucleus of the amygdala to noxious and non-noxious mechanical stimulation in a neuropathic pain model rat
Abstract Previously, we found that serotonin (5-HT) release in the central nucleus of the amygdala (CeA) of anesthetized rats decreases in response to innocuous stroking of the skin, irrespective of stimulus laterality, but increases in response to noxious pinching applied to a hindlimb contralatera...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-03-01
|
| Series: | Journal of Physiological Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12576-024-00910-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849304725075263488 |
|---|---|
| author | Ryota Tokunaga Hideshi Shibata Mieko Kurosawa |
| author_facet | Ryota Tokunaga Hideshi Shibata Mieko Kurosawa |
| author_sort | Ryota Tokunaga |
| collection | DOAJ |
| description | Abstract Previously, we found that serotonin (5-HT) release in the central nucleus of the amygdala (CeA) of anesthetized rats decreases in response to innocuous stroking of the skin, irrespective of stimulus laterality, but increases in response to noxious pinching applied to a hindlimb contralateral to the 5-HT measurement site. The aim of the present study was to determine whether intra-CeA 5-HT release responses to cutaneous stimulation were altered in an animal model of neuropathic pain induced by ligation of the left L5 spinal nerve. In anesthetized neuropathic pain model rats, stroking of the left hindlimb increased 5-HT release in the CeA, whereas stroking of the right hindlimb decreased it. Meanwhile, pinching of the left hindlimb increased intra-CeA 5-HT release irrespective of stimulus laterality. In conclusion, the present study demonstrated that intra-CeA 5-HT release responses to cutaneous stimulation are altered in an animal model of neuropathic pain. |
| format | Article |
| id | doaj-art-3aef990cdd6940aeaf3a502477d8cf60 |
| institution | Kabale University |
| issn | 1880-6562 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Physiological Sciences |
| spelling | doaj-art-3aef990cdd6940aeaf3a502477d8cf602025-08-20T03:55:40ZengElsevierJournal of Physiological Sciences1880-65622024-03-017411810.1186/s12576-024-00910-xAlteration of serotonin release response in the central nucleus of the amygdala to noxious and non-noxious mechanical stimulation in a neuropathic pain model ratRyota Tokunaga0Hideshi Shibata1Mieko Kurosawa2Center for Medical Sciences, International University of Health and WelfareLaboratory of Veterinary Anatomy, Institute of Agriculture, Tokyo University of Agriculture and TechnologyCenter for Medical Sciences, International University of Health and WelfareAbstract Previously, we found that serotonin (5-HT) release in the central nucleus of the amygdala (CeA) of anesthetized rats decreases in response to innocuous stroking of the skin, irrespective of stimulus laterality, but increases in response to noxious pinching applied to a hindlimb contralateral to the 5-HT measurement site. The aim of the present study was to determine whether intra-CeA 5-HT release responses to cutaneous stimulation were altered in an animal model of neuropathic pain induced by ligation of the left L5 spinal nerve. In anesthetized neuropathic pain model rats, stroking of the left hindlimb increased 5-HT release in the CeA, whereas stroking of the right hindlimb decreased it. Meanwhile, pinching of the left hindlimb increased intra-CeA 5-HT release irrespective of stimulus laterality. In conclusion, the present study demonstrated that intra-CeA 5-HT release responses to cutaneous stimulation are altered in an animal model of neuropathic pain.https://doi.org/10.1186/s12576-024-00910-xNeuropathic painSerotonin releaseCentral nucleus of the amygdalaStrokingPinchingRat |
| spellingShingle | Ryota Tokunaga Hideshi Shibata Mieko Kurosawa Alteration of serotonin release response in the central nucleus of the amygdala to noxious and non-noxious mechanical stimulation in a neuropathic pain model rat Journal of Physiological Sciences Neuropathic pain Serotonin release Central nucleus of the amygdala Stroking Pinching Rat |
| title | Alteration of serotonin release response in the central nucleus of the amygdala to noxious and non-noxious mechanical stimulation in a neuropathic pain model rat |
| title_full | Alteration of serotonin release response in the central nucleus of the amygdala to noxious and non-noxious mechanical stimulation in a neuropathic pain model rat |
| title_fullStr | Alteration of serotonin release response in the central nucleus of the amygdala to noxious and non-noxious mechanical stimulation in a neuropathic pain model rat |
| title_full_unstemmed | Alteration of serotonin release response in the central nucleus of the amygdala to noxious and non-noxious mechanical stimulation in a neuropathic pain model rat |
| title_short | Alteration of serotonin release response in the central nucleus of the amygdala to noxious and non-noxious mechanical stimulation in a neuropathic pain model rat |
| title_sort | alteration of serotonin release response in the central nucleus of the amygdala to noxious and non noxious mechanical stimulation in a neuropathic pain model rat |
| topic | Neuropathic pain Serotonin release Central nucleus of the amygdala Stroking Pinching Rat |
| url | https://doi.org/10.1186/s12576-024-00910-x |
| work_keys_str_mv | AT ryotatokunaga alterationofserotoninreleaseresponseinthecentralnucleusoftheamygdalatonoxiousandnonnoxiousmechanicalstimulationinaneuropathicpainmodelrat AT hideshishibata alterationofserotoninreleaseresponseinthecentralnucleusoftheamygdalatonoxiousandnonnoxiousmechanicalstimulationinaneuropathicpainmodelrat AT miekokurosawa alterationofserotoninreleaseresponseinthecentralnucleusoftheamygdalatonoxiousandnonnoxiousmechanicalstimulationinaneuropathicpainmodelrat |