Study of Glutathione S-Transferase, Its Isoenzyme (Pi) and Tumor Marker (CA15-3, HE4) in Breast Carcinoma Patients (Before and After Treatment)
Breast cancer is a prevalent malignancy among women worldwide, with prognosis and survival heavily influenced by early diagnosis and effective treatment. This study evaluates the diagnostic and prognostic significance of glutathione S-transferase (GST), its isoenzyme GST-Pi, and tumor markers CA15-3...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-05-01
|
| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_1792_24 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850122910638800896 |
|---|---|
| author | Dattu Hawale Leela Abichandani Ranjit Ambad |
| author_facet | Dattu Hawale Leela Abichandani Ranjit Ambad |
| author_sort | Dattu Hawale |
| collection | DOAJ |
| description | Breast cancer is a prevalent malignancy among women worldwide, with prognosis and survival heavily influenced by early diagnosis and effective treatment. This study evaluates the diagnostic and prognostic significance of glutathione S-transferase (GST), its isoenzyme GST-Pi, and tumor markers CA15-3 and HE4 in breast carcinoma patients before and after treatment. It also explores the correlation of these biomarkers with liver enzymes (SGOT, SGPT, LDH, ALP), commonly associated with hepatic metastasis. A quasi-experimental design will include 311 participants from the Vidarbha region, clinically diagnosed with breast carcinoma. Blood samples will be analyzed using enzyme-linked immunosorbent assay (ELISA) and automated biochemical analyzers to estimate levels of GST, GST-Pi, CA15-3, HE4, and liver enzymes. The study aims to identify reliable biomarkers for monitoring therapeutic efficacy, assessing prognosis, and predicting recurrence in breast carcinoma. This research may contribute to developing cost-effective diagnostic approaches, particularly beneficial in resource-limited healthcare settings. |
| format | Article |
| id | doaj-art-3aef04c4aabc48348e249c09a2155ad4 |
| institution | OA Journals |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-3aef04c4aabc48348e249c09a2155ad42025-08-20T02:34:43ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062025-05-0117Suppl 1S909S91210.4103/jpbs.jpbs_1792_24Study of Glutathione S-Transferase, Its Isoenzyme (Pi) and Tumor Marker (CA15-3, HE4) in Breast Carcinoma Patients (Before and After Treatment)Dattu HawaleLeela AbichandaniRanjit AmbadBreast cancer is a prevalent malignancy among women worldwide, with prognosis and survival heavily influenced by early diagnosis and effective treatment. This study evaluates the diagnostic and prognostic significance of glutathione S-transferase (GST), its isoenzyme GST-Pi, and tumor markers CA15-3 and HE4 in breast carcinoma patients before and after treatment. It also explores the correlation of these biomarkers with liver enzymes (SGOT, SGPT, LDH, ALP), commonly associated with hepatic metastasis. A quasi-experimental design will include 311 participants from the Vidarbha region, clinically diagnosed with breast carcinoma. Blood samples will be analyzed using enzyme-linked immunosorbent assay (ELISA) and automated biochemical analyzers to estimate levels of GST, GST-Pi, CA15-3, HE4, and liver enzymes. The study aims to identify reliable biomarkers for monitoring therapeutic efficacy, assessing prognosis, and predicting recurrence in breast carcinoma. This research may contribute to developing cost-effective diagnostic approaches, particularly beneficial in resource-limited healthcare settings.https://journals.lww.com/10.4103/jpbs.jpbs_1792_24breast carcinomaca15-3glutathione s-transferasegst-pihe4liver enzymes |
| spellingShingle | Dattu Hawale Leela Abichandani Ranjit Ambad Study of Glutathione S-Transferase, Its Isoenzyme (Pi) and Tumor Marker (CA15-3, HE4) in Breast Carcinoma Patients (Before and After Treatment) Journal of Pharmacy and Bioallied Sciences breast carcinoma ca15-3 glutathione s-transferase gst-pi he4 liver enzymes |
| title | Study of Glutathione S-Transferase, Its Isoenzyme (Pi) and Tumor Marker (CA15-3, HE4) in Breast Carcinoma Patients (Before and After Treatment) |
| title_full | Study of Glutathione S-Transferase, Its Isoenzyme (Pi) and Tumor Marker (CA15-3, HE4) in Breast Carcinoma Patients (Before and After Treatment) |
| title_fullStr | Study of Glutathione S-Transferase, Its Isoenzyme (Pi) and Tumor Marker (CA15-3, HE4) in Breast Carcinoma Patients (Before and After Treatment) |
| title_full_unstemmed | Study of Glutathione S-Transferase, Its Isoenzyme (Pi) and Tumor Marker (CA15-3, HE4) in Breast Carcinoma Patients (Before and After Treatment) |
| title_short | Study of Glutathione S-Transferase, Its Isoenzyme (Pi) and Tumor Marker (CA15-3, HE4) in Breast Carcinoma Patients (Before and After Treatment) |
| title_sort | study of glutathione s transferase its isoenzyme pi and tumor marker ca15 3 he4 in breast carcinoma patients before and after treatment |
| topic | breast carcinoma ca15-3 glutathione s-transferase gst-pi he4 liver enzymes |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_1792_24 |
| work_keys_str_mv | AT dattuhawale studyofglutathionestransferaseitsisoenzymepiandtumormarkerca153he4inbreastcarcinomapatientsbeforeandaftertreatment AT leelaabichandani studyofglutathionestransferaseitsisoenzymepiandtumormarkerca153he4inbreastcarcinomapatientsbeforeandaftertreatment AT ranjitambad studyofglutathionestransferaseitsisoenzymepiandtumormarkerca153he4inbreastcarcinomapatientsbeforeandaftertreatment |