Analgesic effect of intranasal ketamine in the treatment of chronic cancer pain
<strong>Background</strong>: cancer pain remains difficult to treat, especially when the patient is resistant to opioids. More and more alternatives are being sought to counteract and improve the symptoms caused by the disease. One of them is ketamine, which acts as an antagonist of NMDA...
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Centro Provincial de Información de Ciencias Médicas. Cienfuegos
2022-05-01
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| Online Access: | http://medisur.sld.cu/index.php/medisur/article/view/5251 |
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| author | Secundino González Pardo Lourdes González-Longoria Boada Francisco López Muñoz |
| author_facet | Secundino González Pardo Lourdes González-Longoria Boada Francisco López Muñoz |
| author_sort | Secundino González Pardo |
| collection | DOAJ |
| description | <strong>Background</strong>: cancer pain remains difficult to treat, especially when the patient is resistant to opioids. More and more alternatives are being sought to counteract and improve the symptoms caused by the disease. One of them is ketamine, which acts as an antagonist of NMDA receptors that are associated in response to pain.<br /><strong>Objective:</strong> to evaluate the efficacy of the analgesic response to cancer pain with the intranasal administration of ketamine as an adjuvant in pharmacological treatment. <br /><strong>Methods</strong>: research carried out in Ecuador pain clinic. A randomized, double-blind, placebo-controlled cohort study was conducted. 142 participants were included. Two treatments were administered: intranasal ketamine and placebo, which were used in combination with morphine. Participants received periodic visual analog pain scale assessments for three consecutive days.<br /><strong>Results:</strong> the mean age was 69.11 ± 9.77 years. The pancreatic head tumor (44.37%) was the most frequently carcinoma. There were significant differences between administered treatments, clinical aspects and pain (p < 0.05). The patients who were treated with ketamine had a more relevant analgesic effect than the patients who received the placebo. The main side effect was nausea (11.43%).<br /><strong>Conclusions:</strong> patients treated with ketamine experienced better analgesia than the control group. Ketamine represents an option for pain in those who do not respond to conventional opioid treatment. Adverse effects may limit its application in some patients. |
| format | Article |
| id | doaj-art-3aecc5d26cdd48518121326e90857e60 |
| institution | Kabale University |
| issn | 1727-897X |
| language | Spanish |
| publishDate | 2022-05-01 |
| publisher | Centro Provincial de Información de Ciencias Médicas. Cienfuegos |
| record_format | Article |
| series | Medisur |
| spelling | doaj-art-3aecc5d26cdd48518121326e90857e602025-01-30T21:28:58ZspaCentro Provincial de Información de Ciencias Médicas. CienfuegosMedisur1727-897X2022-05-012034874952143Analgesic effect of intranasal ketamine in the treatment of chronic cancer painSecundino González Pardo0Lourdes González-Longoria Boada1Francisco López Muñoz2Facultad de Salud Pública. Universidad Camilo José Cela. Madrid. EspañaFacultad de Ciencias de la Salud Enrique Ortega Moreira. Universidad de Especialidades Espíritu Santo. EcuadorFacultad de Salud Pública. Universidad Camilo José Cela. Madrid. España<strong>Background</strong>: cancer pain remains difficult to treat, especially when the patient is resistant to opioids. More and more alternatives are being sought to counteract and improve the symptoms caused by the disease. One of them is ketamine, which acts as an antagonist of NMDA receptors that are associated in response to pain.<br /><strong>Objective:</strong> to evaluate the efficacy of the analgesic response to cancer pain with the intranasal administration of ketamine as an adjuvant in pharmacological treatment. <br /><strong>Methods</strong>: research carried out in Ecuador pain clinic. A randomized, double-blind, placebo-controlled cohort study was conducted. 142 participants were included. Two treatments were administered: intranasal ketamine and placebo, which were used in combination with morphine. Participants received periodic visual analog pain scale assessments for three consecutive days.<br /><strong>Results:</strong> the mean age was 69.11 ± 9.77 years. The pancreatic head tumor (44.37%) was the most frequently carcinoma. There were significant differences between administered treatments, clinical aspects and pain (p < 0.05). The patients who were treated with ketamine had a more relevant analgesic effect than the patients who received the placebo. The main side effect was nausea (11.43%).<br /><strong>Conclusions:</strong> patients treated with ketamine experienced better analgesia than the control group. Ketamine represents an option for pain in those who do not respond to conventional opioid treatment. Adverse effects may limit its application in some patients.http://medisur.sld.cu/index.php/medisur/article/view/5251ketaminaabsorción nasaldolor crónicodolor en cáncer |
| spellingShingle | Secundino González Pardo Lourdes González-Longoria Boada Francisco López Muñoz Analgesic effect of intranasal ketamine in the treatment of chronic cancer pain Medisur ketamina absorción nasal dolor crónico dolor en cáncer |
| title | Analgesic effect of intranasal ketamine in the treatment of chronic cancer pain |
| title_full | Analgesic effect of intranasal ketamine in the treatment of chronic cancer pain |
| title_fullStr | Analgesic effect of intranasal ketamine in the treatment of chronic cancer pain |
| title_full_unstemmed | Analgesic effect of intranasal ketamine in the treatment of chronic cancer pain |
| title_short | Analgesic effect of intranasal ketamine in the treatment of chronic cancer pain |
| title_sort | analgesic effect of intranasal ketamine in the treatment of chronic cancer pain |
| topic | ketamina absorción nasal dolor crónico dolor en cáncer |
| url | http://medisur.sld.cu/index.php/medisur/article/view/5251 |
| work_keys_str_mv | AT secundinogonzalezpardo analgesiceffectofintranasalketamineinthetreatmentofchroniccancerpain AT lourdesgonzalezlongoriaboada analgesiceffectofintranasalketamineinthetreatmentofchroniccancerpain AT franciscolopezmunoz analgesiceffectofintranasalketamineinthetreatmentofchroniccancerpain |